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ClinicalTrials.gov public records Last synced Oct 17, 2026, 6:56 PM EDT

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Showing 1–24 of 145 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Precedex Clear all
Withdrawn Phase 4 Interventional

Bariatric Dose-ranging Study With Dexmedetomidine

NCT00363935
View directory record Official record
Conditions
Abdominal Surgery Patients
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Timeline
2007
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Oct 17, 2026, 6:56 PM EDT
Recruiting No phase listed Observational

Comparison of Two Sedation Regimens for Awake Fiberoptic Intubation

NCT05736198
View directory record Official record
Conditions
Awake Fiberoptic Intubation, Difficult Airway
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2034
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 17, 2026, 6:56 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Evaluating the Effects of Propofol vs. Dexmedetomidine

NCT03552146
View directory record Official record
Conditions
Sedative Adverse Reaction
Interventions
Propofol, Dexmedetomidine
Drug
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
3 Months to 36 Months
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 4 Interventional Results available

Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea

NCT01344759
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Dexmedetomidine, Propofol
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Months to 25 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 8, 2018 · Synced Oct 17, 2026, 6:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients

NCT00417664
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine, Propofol, Midazolam
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 89 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 27, 2022 · Synced Oct 17, 2026, 6:56 PM EDT
Terminated Phase 3 Interventional Results available

Comparing Safety and Efficacy of Dexmedetomidine and Propofol

NCT01152021
View directory record Official record
Conditions
Safety and Efficacy of Sedation Medications
Interventions
Dexmedetomidine, Propofol
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years to 11 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 21, 2019 · Synced Oct 17, 2026, 6:56 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Providing "Good Sleep" for ICU Sedation

NCT01342328
View directory record Official record
Conditions
Sleep Disorders
Interventions
Normal saline infusion, Dexmedetomidine, Propofol
Other · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 45 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 4 Interventional Results available

Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure

NCT02203019
View directory record Official record
Conditions
Sepsis, Respiratory Failure, Agitation
Interventions
Propofol, Dexmedetomidine, Fentanyl
Drug
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 89 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2020 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 4 Interventional

Sleep Intervention During Acute Lung Injury

NCT01050699
View directory record Official record
Conditions
Critical Illness, Sleep, Acute Lung Injury, Acute Respiratory Distress Syndrome
Interventions
Dexmedetomidine, Midazolam and Fentanyl
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
2
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 3 Interventional Results available

Cerebral Perfusion Pressure Using Precedex and Other Sedatives

NCT01169467
View directory record Official record
Conditions
Endotracheal Intubation, Continuous IV Sedation, ICP Monitoring
Interventions
Standard-of-Care plus Dexmedetomidine, Standard-of-Care
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 2, 2015 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Not applicable Interventional

Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery

NCT06502002
View directory record Official record
Conditions
Surgery-Complications, Respiratory Complication, Lung Injury, Acute
Interventions
Dexmedetomidine Hydrochloride, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 17, 2026, 6:56 PM EDT
Withdrawn No phase listed Observational

Effect of Dexmedetomidine on Pacemaker Function Following Cardiac Surgery

NCT02709200
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Dexmedetomidine
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
6 Months and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Oct 17, 2026, 6:56 PM EDT
Recruiting Phase 1 Interventional

Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

NCT06335407
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Interventions
Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg, Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg
Drug
Lead sponsor
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Other
Eligibility
21 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 17, 2026, 6:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Study Using Dexmedetomidine to Decreases Emergence Delirium in Pediatric Patients

NCT00778063
View directory record Official record
Conditions
Otitis Media
Interventions
dexmedetomidine, saline
Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
1 Year to 5 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 1 Interventional Results available

Susceptibility of Motor-Evoked Potentials to Varying Targeted Blood Levels of Dexmedetomidine

NCT00671931
View directory record Official record
Conditions
Scoliosis
Interventions
low dexmedetomidine, low propofol, high dexmedetomidine, low propofol, Dexmedetomidine, Dexmedetomidin
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 25 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 23, 2013 · Synced Oct 17, 2026, 6:56 PM EDT
Active, not recruiting Phase 3 Interventional

Goal-Directed Sedation in Mechanically Ventilated Infants and Children

NCT04801589
View directory record Official record
Conditions
Delirium, Critical Illness, Sedation Complication, Executive Dysfunction, Post Traumatic Stress Disorder
Interventions
Dexmedetomidine, Midazolam
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
44 Weeks to 11 Years
Enrollment
372 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Dexmedetomidine vs Fentanyl for BMT

NCT00654329
View directory record Official record
Conditions
Otitis
Interventions
Saline, Fentanyl, Dexmedetomidine
Drug
Lead sponsor
Children's National Research Institute
Other
Eligibility
6 Months to 6 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 25, 2011 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Dexmedetomidine in Pediatric Tonsillectomy

NCT01057381
View directory record Official record
Conditions
Pediatric Adenotonsillectomy, Post Operative Analgesia
Interventions
Dexmedetomidine 0.75 mcg/kg, Morphine 50 mcg/kg, Morphine 100 mcg/kg, Dexmedetomidine 1 mcg/kg
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
3 Years to 17 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2021 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep

NCT02856594
View directory record Official record
Conditions
Postoperative Delirium, Sleep, Anesthesia
Interventions
Dexmedetomidine, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older
Enrollment
469 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 3 Interventional Results available

Dexmedetomidine as a Rapid Bolus in Children for Emergence Agitation

NCT01528891
View directory record Official record
Conditions
Tonsillectomy
Interventions
Dexmedetomidine, Placebo
Drug · Other
Lead sponsor
Peter Davis
Other
Eligibility
4 Years to 10 Years
Enrollment
418 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Dexmedetomidine in Seizure Patients

NCT01116700
View directory record Official record
Conditions
Seizure Disorders
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 9, 2013 · Synced Oct 17, 2026, 6:56 PM EDT
Withdrawn Phase 2 Interventional

Safety of Dexmedetomidine in Severe Traumatic Brain Injury

NCT01007773
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Precedex, Propofol, Fentanyl
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Oct 17, 2026, 6:56 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Opioid-Free Anesthetic for Tonsillectomy

NCT04528173
View directory record Official record
Conditions
Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder, Surgery
Interventions
Ketorolac, Dexmedetomidine, Morphine, Fentanyl
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Years to 18 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 17, 2026, 6:56 PM EDT
Completed Not applicable Interventional Results available

A Comparison of Remifentanil and Dexmedetomidine for Craniotomy Perioperative Hemodynamics and Postoperative Pain

NCT01269918
View directory record Official record
Conditions
Adult Intracranial Tumor, Adult Solid Tumor
Interventions
Remifentanil, Dexmedetomidine
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 20, 2016 · Synced Oct 17, 2026, 6:56 PM EDT