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Showing 1–12 of 12 matching trials from the live ClinicalTrials.gov search.

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Filters: Intervention: Pregnenolone 500 mg Clear all

Conditions: Autistic Disorder
Interventions: Pregnenolone; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Stanford, California

Conditions: Major Depressive Disorder
Interventions: Pregnenolone 500 mg, Pregnenolone 800 mg, Placebo; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Traumatic Brain Injury, TBI
Interventions: Pregnenolone, Placebo; Drug
Lead sponsor: Christine Marx, MD; Other
Eligibility: 21 Years to 65 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Durham, North Carolina

Conditions: Traumatic Brain Injury
Interventions: Pregnenolone, Placebo; Drug
Lead sponsor: Durham VA Medical Center; Federal
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Interventions: Pregnenolone, Placebo; Drug
Lead sponsor: Sherwood Brown, MD, PhD; Other
Eligibility: 21 Years to 55 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 2
States / cities: Dallas, Texas • Richardson, Texas

Conditions: Cannabis Intoxication
Interventions: Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg, Placebo, Placebo brownie; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Anxiety and Depression
Interventions: Pregnenolone, Placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Autism Spectrum Disorder, Autism
Interventions: Pregnenolone, Placebo; Drug
Lead sponsor: Stanford University; Other
Eligibility: 14 Years to 25 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Major Depressive Disorder, Anxiety Depression, HIV
Interventions: Placebo, Pregnenolone; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronic Low Back Pain
Interventions: Pregnenolone, DHEA, Placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Alcohol Use Disorder, Bipolar Disorder, Schizoaffective Disorder Bipolar Type
Interventions: Placebo, Citicoline, Pregnenolone; Drug · Dietary Supplement
Lead sponsor: Sherwood Brown, MD, PhD; Other
Eligibility: 18 Years to 70 Years
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 3
States / cities: Miami, Florida • Dallas, Texas • Edinburg, Texas

Conditions: Cocaine-Related Disorders
Interventions: Pregnenolone (PREG), Placebos; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut