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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.

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Filters: Intervention: Prenatal Genomic Sequencing Clear all

Conditions: Fetal Structural Anomalies
Interventions: Prenatal Genomic Sequencing; Diagnostic Test
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 1,097 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 5
States / cities: New York, New York • Chapel Hill, North Carolina • Cincinnati, Ohio + 1 more

Conditions: Fetal Structural Anomalies
Interventions: Genomic Sequencer; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 64 Years
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2030
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Pregnant Individuals Requesting Standard Microarray
Interventions: Genomic Sequencing; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 64 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Encephalopathy, Birth Defect, Intellectual Disability, Multiple Congenital Anomaly, Metabolic Disease, Epilepsy, Neuro-Degenerative Disease, Cerebral Palsy, Developmental Delay, Developmental Defect
Interventions: Whole Exome Sequencing; Diagnostic Test
Lead sponsor: University of California, San Francisco; Other
Eligibility: Up to 25 Years
Enrollment: 529 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 4
States / cities: Fresno, California • Oakland, California • San Francisco, California

Conditions: Prenatal Genetic Diagnosis
Interventions: Genome Sequencing (GS); Genetic
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 1,042 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 3
States / cities: Boston, Massachusetts • New York, New York

Conditions: Pregnant
Interventions: Not listed
Lead sponsor: National Human Genome Research Institute (NHGRI); NIH
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 553 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Falls Church, Virginia

Conditions: Nonimmune Fetal Hydrops, Nonimmune Hydrops in Neonate, Genetic Disorders
Interventions: Whole Exome Sequencing, Whole Genome Sequencing; Diagnostic Test
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 16 Years to 55 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cardiovascular Phenotype, Metabolic Phenotype, Hypertensive Disease, Psychological Phenotype, Audio
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 99 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Hydrops Fetalis, Birth Defect, Fetal Anomaly
Interventions: Exome sequencing; Diagnostic Test
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 55 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Genetic Diseases, Genetic Syndrome, Mendelian Disorders
Interventions: Genomic sequencing and molecular diagnostic results, if any.; Genetic
Lead sponsor: Rady Pediatric Genomics & Systems Medicine Institute; Other
Eligibility: Up to 4 Months
Enrollment: 213 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: San Diego, California

Conditions: Major Fetal Anomaly
Interventions: Whole Genome Sequencing, Amniocentesis, Psychosocial assessment; Genetic · Procedure · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: San Diego, California

Conditions: Structural Anomalies, Cardiac Anomalies, Central Nervous System Anomalies, Thorax Anomalies, Genito-urinary Anomalies, Gastrointestinal Anomalies, Skeletal Anomalies, Multiple Anomalies
Interventions: Whole Exome Sequencing (WES); Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 64 Years · Female only
Enrollment: 316 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Non-Immune Hydrops Fetalis
Interventions: Whole genome sequencing; Diagnostic Test
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 60 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Trisomy 21 in Fetus
Interventions: MaterniT21 PLUS and GENOME Laboratory-Developed Tests; Device
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older · Female only
Enrollment: 2,000 participants
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Congenital Heart Disease
Interventions: Whole Genome Sequencing (WGC) from subject samples; Diagnostic Test
Lead sponsor: Scripps Translational Science Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: San Diego, California

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Prenatal Genetic Diagnosis by Genomic Sequencing

Genomic Sequencing for Evaluation of Fetal Structural Anomalies

Genomic Sequencing in Anatomically Normal Fetuses

Clinical Utility of Pediatric Whole Exome Sequencing

guideSEQ: Genomic Understanding, Impact, Decision & Ethics in Prenatal Sequencing

Pregnant Women s Views About the Ethics of Prenatal Whole Genome Sequencing

Whole Exome Sequencing and Whole Genome Sequencing for Nonimmune Fetal/Neonatal Hydrops

Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study

Hydrops: Diagnosing & Redefining Outcomes With Precision Study

Perinatal Precision Medicine

Development of an Optimal Approach to Return of Results for Next-generation Sequencing for Prenatal Diagnosis

Clinical Utility of Prenatal Whole Exome Sequencing

Uncovering the Etiologies of Non-immune Hydrops Fetalis

Clinical Performance of NIPT in Multiple Gestation Pregnancies

The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study