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ClinicalTrials.gov public records Last synced Oct 18, 2026, 6:31 PM EDT

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Showing 385–408 of 437 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Probiotic Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Plasma Amino Acid Response to Whey Protein Ingestion Following 28-days of Probiotic Supplementation

NCT04491188
View directory record Official record
Conditions
Focus of Study is Amino Acid Appearace in Blood
Interventions
Bacillus subtilis DE111, Placebo
Dietary Supplement
Lead sponsor
Lipscomb University
Other
Eligibility
18 Years to 34 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Personalized Lifestyle Intervention for Improving Functional Health Outcomes Using N-of-1 Tent-Umbrella-Bucket Design

NCT04005456
View directory record Official record
Conditions
Health, Subjective, Gastrointestinal Dysfunction, Cardiovascular Risk Factor, Autoimmune Diseases, Dental Diseases, Hormone Disturbance, Neurocognitive Dysfunction
Interventions
Supplements and/or medical foods, Behavioral change support program, Food plan
Dietary Supplement · Behavioral · Other
Lead sponsor
Metagenics, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Gig Harbor, Washington
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Probiotic Blend Reduces Gastrointestinal Symptoms and Positively Impacts Microbiota Modulation in a Randomized Study

NCT05614726
View directory record Official record
Conditions
Microbiota, Constipation, Candida
Interventions
575mg [30 billion colony forming units] probiotic blend of Bifidobacterium breve, Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, Saccharomyces boulardii, and alpha amylase
Dietary Supplement
Lead sponsor
The Center for Applied Health Sciences, LLC
Industry
Eligibility
30 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing Early Behavioral Indicators of Formula Tolerance

NCT02340143
View directory record Official record
Conditions
Tolerance
Interventions
Control, Investigational
Other
Lead sponsor
Mead Johnson Nutrition
Industry
Eligibility
14 Days to 28 Days
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 14, 2016 · Synced Oct 18, 2026, 6:31 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID

NCT06560554
View directory record Official record
Conditions
Long COVID
Interventions
Fermented foods, Control
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional

Probiotics in Primary Care

NCT01254097
View directory record Official record
Conditions
Antibiotic Side Effect
Interventions
Probiotic
Dietary Supplement
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 79 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 25, 2015 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional

The Effects of an Orally-Administered Probiotic on Vaginal Symptoms

NCT07829861
View directory record Official record
Conditions
Vaginal Odor
Interventions
Orally-administered probiotic, Placebo
Dietary Supplement
Lead sponsor
Bonafide Health
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Harrison, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional

Maternal Probiotic Supplementation for Improved Outcomes in Infants of Diabetic Mothers

NCT05467150
View directory record Official record
Conditions
Infant of Diabetic Mother
Interventions
Probiotic Supplement
Dietary Supplement
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 18, 2026, 6:31 PM EDT
Terminated Not applicable Interventional

The Effects of Probiotic Supplementation on Extremely Low Birthweight Infants

NCT01788761
View directory record Official record
Conditions
Feeding Tolerance
Interventions
Probiotic Supplemented Group, Control Group
Dietary Supplement
Lead sponsor
Mercy Health System
Network
Eligibility
Up to 14 Days
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Rockford, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Probiotic for Oral Health (PRO Health) Study

NCT03748017
View directory record Official record
Conditions
Oral Microbiome
Interventions
Placebo-Control Supplement, Streptococcus-Containing Probiotic Supplement
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
21 Years to 45 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 18, 2026, 6:31 PM EDT
Recruiting Phase 2 Interventional

The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

NCT06211062
View directory record Official record
Conditions
ME/CFS, IBS - Irritable Bowel Syndrome
Interventions
Floradapt Intensive GI, Placebo
Drug · Other
Lead sponsor
Nova Southeastern University
Other
Eligibility
45 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 18, 2026, 6:31 PM EDT
Recruiting Early Phase 1 Interventional

Oral 5 Strain Probiotic for GI Toxicity Mitigation During Pelvic Radiation

NCT07231588
View directory record Official record
Conditions
Radiation Injuries
Interventions
Pendulum Glucose Control (PGC)
Biological
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study of the Effects of Probiotics in Children Grades 1-3

NCT00635388
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Lactobacillus (Probiotic 1), Lactobacillus and Bifidobacterium (Probiotic 2)
Other
Lead sponsor
Procter and Gamble
Industry
Eligibility
5 Years to 9 Years
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 16, 2009 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Yogurt Containing BB12 in Subjects With GI Symptoms

NCT00618488
View directory record Official record
Conditions
Pain
Interventions
Probiotic BB12 - Bifidobacterium lactis, Placebo
Dietary Supplement
Lead sponsor
University of North Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2008 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Probiotic on the Innate and Adaptive Host Response to Rhinovirus (EPIARR)

NCT01669603
View directory record Official record
Conditions
Common Cold
Interventions
Bifidobacterium lactis Bl-04, Placebo, Rhinovirus
Dietary Supplement · Biological
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 60 Years
Enrollment
789 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Oct 18, 2026, 6:31 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Consumer Health Study Aims to Evaluate the Safety, Tolerability and Impact of ED02 Probiotic Supplement on Gastrointestinal Outcomes

NCT07423897
View directory record Official record
Conditions
Gastrointestinal, Gut Health
Interventions
Bifidobacterium pseudocatenulatum, Placebo
Dietary Supplement
Lead sponsor
Synbiotic Health
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 18, 2026, 6:31 PM EDT
Active, not recruiting Not applicable Interventional

Probiotics for Inflammation in Pediatric Chronic Pain

NCT05141890
View directory record Official record
Conditions
Chronic Pain, Body Mass Index >=85th Percentile
Interventions
Lactobacillus Plantarum
Dietary Supplement
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
13 Years to 17 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Effects of Probiotic Supplementation on Markers of Muscle Damage and Performance Following Exercise Induced Muscle Damage

NCT02520583
View directory record Official record
Conditions
Probiotics
Interventions
Lactic acid bacteria and bifidobacteria, Placebo
Dietary Supplement · Other
Lead sponsor
Texas Christian University
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Oct 19, 2016 · Synced Oct 18, 2026, 6:31 PM EDT
Recruiting Phase 1Phase 2 Interventional

Probiotics and Gut Health

NCT03418857
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
Yogurt smoothie with BB-12, Yogurt smoothie
Drug
Lead sponsor
Penn State University
Other
Eligibility
55 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 14, 2021 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Probiotics on Cognition and Health

NCT02849275
View directory record Official record
Conditions
Physiological Stress, Cognition - Other
Interventions
Lactose Free 1% Milk, Probiotic Treatment
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
25 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotic Supplement and Microbiome, Immune System and Metabolic Syndrome

NCT03201068
View directory record Official record
Conditions
Metabolic Syndrome, Microbiome, Immune Function, Inflammation
Interventions
Probiotic supplement, Placebo
Dietary Supplement
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 24, 2023 · Synced Oct 18, 2026, 6:31 PM EDT
Active, not recruiting Phase 2 Interventional

Probiotics to Prevent Relapse After Hospitalization for Bipolar Depression

NCT03349528
View directory record Official record
Conditions
Bipolar Depression
Interventions
Probiotic Supplement, Inert Compound
Biological
Lead sponsor
Sheppard Pratt Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 18, 2026, 6:31 PM EDT
Active, not recruiting Phase 2 Interventional

Reducing Innate Inflammation in New Onset Type 1 Diabetes

NCT04335656
View directory record Official record
Conditions
Type 1 Diabetes, type1diabetes, Type 1 Diabetes Mellitus
Interventions
Lactiplantibacillus plantarum, Placebo
Dietary Supplement · Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
3 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 18, 2026, 6:31 PM EDT
Completed Phase 2 Interventional Results available

Intravaginal LACTIN-V for Prevention of Recurrent Urinary Tract Infection

NCT00305227
View directory record Official record
Conditions
Urinary Tract Infection
Interventions
Lactin-V, Placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Oct 18, 2026, 6:31 PM EDT