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ClinicalTrials.gov public records Last synced Oct 17, 2026, 7:57 AM EDT

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Showing 97–120 of 437 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Probiotic Clear all
Suspended Phase 3 Interventional

BIO-K+ CL1285 for Prevention of Recurrent Clostridium Difficile Infection

NCT01202630
View directory record Official record
Conditions
Recurrent Clostridium Difficile Infection
Interventions
Lactobacillus acidophilus CL1285® and Lactobacillus casei, Placebo
Dietary Supplement
Lead sponsor
Bio-K Plus International Inc.
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2016 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics

NCT03755765
View directory record Official record
Conditions
Antibiotic-associated Diarrhea
Interventions
Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control
Drug · Biological · Other
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 17, 2023 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Phase 4 Interventional

Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

NCT02462590
View directory record Official record
Conditions
Ventilator Associated Pneumonia, Infections, C-Difficile, Antibiotic-associated Diarrhea, Diarrhea
Interventions
L. rhamnosus GG - Probiotic, Placebo - Microcrystalline Cellulose
Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
2,650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Rochester, Minnesota • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Oct 17, 2026, 7:57 AM EDT
Not yet recruiting Not applicable Interventional

Impact of a Human Origin Heat Inactivated Probiotic-Lactobacillus Paracasei D3.5 (LpD3.5) as Dietary Supplement on Gut Mucin and Intestinal Permeability in Adults With IBD

NCT07017959
View directory record Official record
Conditions
Inflammatory Bowel Diseases
Interventions
LpD3.5 supplementation., Placebo
Dietary Supplement
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 17, 2026, 7:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study of the Next-generation Probiotic, Veillonella Atypica FB0054 vs Placebo

NCT06141343
View directory record Official record
Conditions
Fatigue
Interventions
Veillonella atypica FB0054, Placebo
Dietary Supplement · Other
Lead sponsor
FitBiomics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Oct 17, 2026, 7:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Novel Probiotic Treatment for Prevention of Recurrent UTIs in Children

NCT01696227
View directory record Official record
Conditions
Recurrent UTIs, Catheter-Related Infections
Interventions
Nissle 1917
Drug
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 15, 2014 · Synced Oct 17, 2026, 7:57 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

L. Acidophilus (Strain TW01) on Gut Health, Body Composition, and Inflammation

NCT06912100
View directory record Official record
Conditions
Overweight (BMI > 25), Obese, Otherwise Healthy Volunteers
Interventions
Placebo, Probiotic
Dietary Supplement
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic

NCT01279265
View directory record Official record
Conditions
Colic, Inflammation
Interventions
Nutramigen with Enflora, Nutramigen A+
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
3 Weeks to 3 Months
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2015 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Phase 2 Interventional Results available

The Probiotic Study: Using Bacteria to Calm Your Mind

NCT02711800
View directory record Official record
Conditions
Anxiety, Abdominal Pain
Interventions
Lactobacillus rhamnosus
Drug
Lead sponsor
Nancy Zucker
Other
Eligibility
9 Years to 13 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Phase 1 Interventional

Probiotic Ingestion and Isoagglutinin Titers

NCT00891787
View directory record Official record
Conditions
Isoagglutinin-Mediated Hemolysis, Probiotic Toxicity
Interventions
Probiotic Supplement
Dietary Supplement
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 70 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 17, 2026, 7:57 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of GlutenShield, a Prebiotic, Probiotic, and Enzyme Supplement, on the Gut Microbiome of Adults With GI Symptoms

NCT03403387
View directory record Official record
Conditions
Gastrointestinal Symptoms
Interventions
GlutenShield, Placebo
Dietary Supplement · Other
Lead sponsor
East Tennessee State University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Johnson City, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 18, 2018 · Synced Oct 17, 2026, 7:57 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Infant Microbiota and Probiotic Intake Study

NCT02457338
View directory record Official record
Conditions
Healthy
Interventions
Bifidobacterium
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2027
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 17, 2026, 7:57 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Bifidobacterium Lactis HN019 Supplementation for Prevention of Influenza Infection in Healthy Adults

NCT01258842
View directory record Official record
Conditions
Influenza
Interventions
Bifidobacterium lactis HN019, Placebo
Dietary Supplement
Lead sponsor
Fonterra Research Centre
Industry
Eligibility
18 Years to 60 Years
Enrollment
426 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
2
States / cities
Coral Gables, Florida • Rochester, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 13, 2010 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of a Probiotic Supplement to Prevent Asthma in Infants

NCT00113659
View directory record Official record
Conditions
Asthma
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
Montefiore Medical Center
Other
Eligibility
1 Day to 4 Days
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Oct 17, 2026, 7:57 AM EDT
Active, not recruiting Phase 1 Interventional

CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer

NCT05122546
View directory record Official record
Conditions
Advanced Clear Cell Renal Cell Carcinoma, Advanced Papillary Renal Cell Carcinoma, Advanced Renal Cell Carcinoma, Advanced Sarcomatoid Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Papillary Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Metastatic Sarcomatoid Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8, Unresectable Clear Cell Renal Cell Carcinoma, Unresectable Renal Cell Carcinoma
Interventions
Cabozantinib S-malate, Clostridium butyricum CBM 588 Probiotic Strain, Nivolumab
Drug · Biological
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety of Lactobacillus Reuteri (L. Reuteri) in Healthy Adults

NCT00922727
View directory record Official record
Conditions
Colic, Gastrointestinal Tract Infections
Interventions
L. reuteri, Sunflower Oil
Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Not applicable Interventional

A Study of Protein Metabolism, Microbiome and Investigational Probiotic Use in Patients With ALS

NCT03324399
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis, ALS
Interventions
probiotic
Dietary Supplement
Lead sponsor
Avera McKennan Hospital & University Health Center
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Jul 2, 2019 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutrition Interventions to Support the Immune System in Response to Stress

NCT02053506
View directory record Official record
Conditions
Mitigation of Immune Function Decrements in Response to Stress
Interventions
Immune-enhancing nutritional beverage, Probiotics (BB-12), Placebo (for nutritional beverage and probiotic)
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 45 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tolerability and Functional Assessment of a Novel Children's Synbiotic

NCT04534036
View directory record Official record
Conditions
Constipation, Signs and Symptoms, Digestive Signs and Symptoms, Infrequent or Difficult Evacuation
Interventions
PDS-08, Placebo
Dietary Supplement · Other
Lead sponsor
Seed Health
Industry
Eligibility
3 Years to 17 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2022 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Correlating Probiotic Dietary Supplements During Pregnancy With Maternal Microbiome Profiles

NCT03611647
View directory record Official record
Conditions
Pregnancy Related
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
3
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy

NCT01479478
View directory record Official record
Conditions
Infection, Pregnancy
Interventions
Placebo, Probiotic dietary supplement
Drug · Dietary Supplement
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
3
States / cities
Aptos, California • Santa Cruz, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2018 · Synced Oct 17, 2026, 7:57 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Continuous Yogurt Intake on Immunomodulatory Function and Subjective Health Status in Healthy U.S. Adults

NCT07799207
View directory record Official record
Conditions
Immune Function
Interventions
Yogurt drink, Acidified lactic beverage
Dietary Supplement
Lead sponsor
Meiji Co., Ltd.
Industry
Eligibility
18 Years to 65 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Not applicable Interventional

B. Lactis B94 Effects of Gastrointestinal Function

NCT03277157
View directory record Official record
Conditions
Quality of Life
Interventions
B. lactis B94, Placebo
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
3
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 17, 2026, 7:57 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Pinpoint Trial: Prebiotics IN Peanut Oral ImmunoTherapy

NCT05138757
View directory record Official record
Conditions
Peanut Allergy
Interventions
Prebiotic, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
4 Years to 17 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • Hyde Park, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 17, 2026, 7:57 AM EDT