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ClinicalTrials.gov public records Last synced Oct 19, 2026, 10:50 AM EDT

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Showing 145–168 of 437 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Probiotics Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Methylation Diet and Lifestyle Study

NCT03472820
View directory record Official record
Conditions
Lifestyle, Diet, Healthy
Interventions
Diet Recommendations, Lifestyle Recommendations, Exercise Recommendations, Stress Management Recommendations, PhytoGanix (tropical fruit flavor), UltraFlora Intensive Care
Other
Lead sponsor
National University of Natural Medicine
Other
Eligibility
50 Years to 72 Years · Male only
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Oct 19, 2026, 10:50 AM EDT
Active, not recruiting Phase 2 Interventional

Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters

NCT04323735
View directory record Official record
Conditions
Neurogenic Bladder
Interventions
Culturelle 10 Billion CFU Capsule
Drug
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 19, 2026, 10:50 AM EDT
Recruiting Phase 2 Interventional

5-strain Probiotic Formulation in HR-positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss

NCT07044310
View directory record Official record
Conditions
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Hormone Receptor-Positive Breast Carcinoma
Interventions
Biospecimen Collection, Bone Mineral Density Test, Questionnaire Administration, WBF-038
Procedure · Other · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Phase 2 Interventional

Evaluation of FB-401 in Children, Adolescents and Adults (2 Years and Older) With Mild to Moderate Atopic Dermatitis

NCT04504279
View directory record Official record
Conditions
Atopic Dermatitis
Interventions
FB-401, Placebo
Biological
Lead sponsor
Forte Biosciences, Inc.
Industry
Eligibility
2 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
15
States / cities
Fountain Valley, California • Fremont, California • Lake City, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Gut Flora Dependent Metabolism of Dietary Phosphatidylcholine and Cardiovascular Disease

NCT01519310
View directory record Official record
Conditions
Nutrition
Interventions
Antibiotic (metronidazole and ciprofloxacin)/probiotic
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Not applicable Interventional

A Growth and Hypoallergenicity Study of a New Formula for Infants With Cow Milk Allergy

NCT00664768
View directory record Official record
Conditions
Cow Milk Allergy
Interventions
Neocate Infant, new Neocate
Dietary Supplement
Lead sponsor
Nutricia North America
Industry
Eligibility
1 Day to 8 Months
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
22
States / cities
Chandler, Arizona • Tucson, Arizona • Bentonville, Arkansas + 18 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Oct 19, 2026, 10:50 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Symbiotic Use in Post-Bariatric Surgery Patients

NCT06252558
View directory record Official record
Conditions
Bariatric Surgery Candidate
Interventions
Symbiotic, Placebo
Dietary Supplement
Lead sponsor
University of North Florida
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 9, 2024 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Impact of Oligosaccharides and Bifidobacteria on the Intestinal Microflora of Premature Infants

NCT00810160
View directory record Official record
Conditions
Fecal Microflora in the Formula Fed Premature Infant
Interventions
ProlactPlus, GOS galacto-oligosaccharides, Bifidobacterium infantis, Bifidobacterium animalis
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
Not listed
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2017 · Synced Oct 19, 2026, 10:50 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Exploration of Tolerability and Dose Responses for a Yeast-based Probiotic

NCT07867496
View directory record Official record
Conditions
Healthy Adult Participants, Gut Health
Interventions
9.9 x 10^7 Pichia kluyveri PK88, 1 x 10^8 Pichia kluyveri PK88, Placebo
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 19, 2026, 10:50 AM EDT
Recruiting Phase 2 Interventional

CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial

NCT06949800
View directory record Official record
Conditions
HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma, Anal HSIL
Interventions
EXE-346 Probiotic, Placebo, Usual Care High Resolution Anoscopy (HRA)
Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Not applicable Interventional

The Oral Microbiome in OSCC

NCT04925700
View directory record Official record
Conditions
Oral Cancer
Interventions
ProDentis Lozenge, Placebo Lozenge
Dietary Supplement · Other
Lead sponsor
University of Iowa
Other
Eligibility
21 Years to 89 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Decreasing Rates of Illness in Kids (DRINK)

NCT00356382
View directory record Official record
Conditions
Healthy
Interventions
Lactobacillus (L.) casei
Drug
Lead sponsor
Georgetown University
Other
Eligibility
3 Years to 6 Years
Enrollment
638 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 14, 2008 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Phase 2 Interventional

Probiotic Use for Recovery Enhancement From Long COVID-19

NCT06643299
View directory record Official record
Conditions
Post-Acute COVID-19 Syndrome
Interventions
Probiotic Agent, Placebo
Drug · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 19, 2026, 10:50 AM EDT
Recruiting Not applicable Interventional

Efficacy of Viome's Precision Nutrition Program Towards Reducing HbA1c

NCT05465616
View directory record Official record
Conditions
Diabetes, Pre Diabetes
Interventions
Viome's Precision Nutrition Program (VPNP)
Dietary Supplement
Lead sponsor
Viome
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bothell, Washington
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress

NCT05392556
View directory record Official record
Conditions
Stress Physiology
Interventions
Probiotic, Prebiotic, Placebo
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 26, 2025 · Synced Oct 19, 2026, 10:50 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Probiotic (VSL #3) for Gulf War Illness

NCT02011542
View directory record Official record
Conditions
Gulf War Illness
Interventions
VSL#3, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
35 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 26, 2018 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Early Phase 1 Interventional

Effects of Probiotics on the Gut Microbiome and Immune System in Operable Stage I-III Breast or Lung Cancer

NCT04857697
View directory record Official record
Conditions
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Breast Adenocarcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8
Interventions
Biopsy, Biospecimen Collection, Probiotic, Therapeutic Conventional Surgery
Procedure · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 21, 2023 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Bacillus Subtilis BS50 Supplementation on Gastrointestinal Symptoms in Healthy Adults

NCT05004454
View directory record Official record
Conditions
Gastrointestinal Health, Immune Health, Cardiovascular Health, Digestive Health
Interventions
Bacillus subtilis BS50 spore preparation, Maltodextrin
Dietary Supplement
Lead sponsor
BIO-CAT Microbials, LLC
Industry
Eligibility
30 Years to 65 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 5, 2023 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics on Stress-associated Gastrointestinal Function in University Students

NCT03056846
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Probiotic Combination, Bifidobacterium bifidum, Bifidobacterium longum
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
634 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety of Lactobacillus Reuteri (L. Reuteri) in Healthy Adults

NCT00922727
View directory record Official record
Conditions
Colic, Gastrointestinal Tract Infections
Interventions
L. reuteri, Sunflower Oil
Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Oct 19, 2026, 10:50 AM EDT
Active, not recruiting Not applicable Interventional

Probiotics for Inflammation in Pediatric Chronic Pain

NCT05141890
View directory record Official record
Conditions
Chronic Pain, Body Mass Index >=85th Percentile
Interventions
Lactobacillus Plantarum
Dietary Supplement
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
13 Years to 17 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Plasma Amino Acid Appearance After Adding Bacillus Coagulans GBI-30, 6086 to Milk Protein Concentrate

NCT05313178
View directory record Official record
Conditions
Protein Malabsorption
Interventions
Bacillus Coagulans GBI-30, 6086
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
50 Years to 70 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics to Improve Women's Health

NCT01800760
View directory record Official record
Conditions
Healthy
Interventions
Probiotics
Dietary Supplement
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Oct 19, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Impact of CLB101TM️ on Gut Health in Healthy, Overweight Individuals

NCT07336615
View directory record Official record
Conditions
Gastrointestinal, Overweight , Obesity
Interventions
CLB101™️, Placebo, Placebo control
Dietary Supplement · Other
Lead sponsor
ClostraBio Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 19, 2026, 10:50 AM EDT