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ClinicalTrials.gov public records Last synced Oct 2, 2026, 1:47 PM EDT

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Showing 25–48 of 52 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Probiotics - Lactobacillus and bifidobacterium Clear all
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Investigating the Effectiveness of 2 Different Doses of BIOHM FX Probiotic Blend in Improving Digestive Symptoms

NCT06782945
View directory record Official record
Conditions
Moderate Gastrointestinal Discomfort
Interventions
BIOHM FX Probiotic Blend
Dietary Supplement
Lead sponsor
Biohm Technologies
Industry
Eligibility
18 Years to 75 Years
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2025 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Detection of Probiotic Strains in Vaginal Swabs Collected From Healthy Women

NCT04719611
View directory record Official record
Conditions
Healthy
Interventions
Probiotic
Dietary Supplement
Lead sponsor
Lallemand Health Solutions
Industry
Eligibility
18 Years to 40 Years · Female only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Correlating Probiotic Dietary Supplements During Pregnancy With Maternal Microbiome Profiles

NCT03611647
View directory record Official record
Conditions
Pregnancy Related
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
3
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Phase 2 Interventional

Probiotics for Clostridium Difficile Infection in Older Adults

NCT01680874
View directory record Official record
Conditions
Clostridium Difficile
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Pea Proteins on Muscle Damage and Recovery

NCT05657314
View directory record Official record
Conditions
Pea Proteins, Muscle Damage, Amino Acid Change
Interventions
Active Comparator
Dietary Supplement
Lead sponsor
The Center for Applied Health Sciences, LLC
Industry
Eligibility
18 Years to 55 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

The PRIDE Study Probiotics on Regulation and Improving Digestive hEalth

NCT01203462
View directory record Official record
Conditions
Digestive Irregularity, Digestive Discomfort, History of Straining During Bowel Movements, History of Hard or Lumpy Stools
Interventions
Probiotic strain of Bifidobacterium, No Bifidobacterium
Other
Lead sponsor
Georgetown University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 11, 2013 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional

A Study to Assess the Efficacy and Safety of Salix Probiotic Blend in Participants With Functional Gastrointestinal Disturbances

NCT04155801
View directory record Official record
Conditions
Functional Gastrointestinal Disorders
Interventions
Salix Probiotic Blend
Dietary Supplement
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 2, 2026, 1:47 PM EDT
Terminated Phase 1 Interventional

Probiotics in the Reduction of Antibiotic Associated Diarrhea

NCT02589964
View directory record Official record
Conditions
Clostridium Difficile
Interventions
Florajen-3, Placebo
Dietary Supplement · Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years to 120 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional

Ritual Synbiotic+, a Dietary Supplement Designed to Impact Gastrointestinal Health, Mood, and Behavior in Women

NCT06834984
View directory record Official record
Conditions
Gastrointestinal Disease Symptoms
Interventions
Prebiotic, probiotic, postbiotic combination, Placebo
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
25 Years to 65 Years · Female only
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Synbiotic Supplement on Metabolic & Cognitive Outcomes Among Older Adults

NCT06845995
View directory record Official record
Conditions
Older Adults, Bioelectrical Impedance, Appetite Hormones, Metabolic Health, Body Composition Measurement, Cognitive Health
Interventions
Synbiotic supplement
Dietary Supplement
Lead sponsor
Texas Tech University
Other
Eligibility
65 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 2, 2026, 1:47 PM EDT
Withdrawn Not applicable Interventional

Monitoring the Effects of Probiotic Supplementation in Immunocompromised Kidney Transplanted Subjects

NCT05102461
View directory record Official record
Conditions
Diarrhea Caused by Drug, Dysbiosis
Interventions
Florajen Digestion Supplementation, Placebo Supplementation
Dietary Supplement
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Oct 2, 2026, 1:47 PM EDT
Terminated Not applicable Interventional

The Effects of Probiotic Supplementation on Extremely Low Birthweight Infants

NCT01788761
View directory record Official record
Conditions
Feeding Tolerance
Interventions
Probiotic Supplemented Group, Control Group
Dietary Supplement
Lead sponsor
Mercy Health System
Network
Eligibility
Up to 14 Days
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Rockford, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Phase 3 Interventional Results available

A Probiotic Intervention to Prevent Relapse Following Hospitalization for Mania

NCT03383874
View directory record Official record
Conditions
Mania (Neurotic)
Interventions
Probio-Tec BG-VCap-6.5, Placebo
Combination Product · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics, Immunity, Stress, and QofL

NCT05063305
View directory record Official record
Conditions
Stress, Quality of Life
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Probiotics and Health-related Quality of Life in Individuals With Seasonal Allergies

NCT02349711
View directory record Official record
Conditions
Healthy
Interventions
Probiotic mixture, Placebo
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Probiotics on Health-related Quality of Life in College Students With Upper Respiratory Infections

NCT01657643
View directory record Official record
Conditions
Upper Respiratory Infection
Interventions
Probiotics, placebo
Dietary Supplement
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 25 Years
Enrollment
231 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Framingham, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Fecal Recovery of the Probiotic Bacteria Lactobacillus Rhamnosus GG (LGG) and Bifidobacterium Animalis Subspecies Lactis BB-12 (BB-12) in Healthy Humans Following Daily Consumption of a Probiotic Supplement

NCT01757054
View directory record Official record
Conditions
Fecal Analysis
Interventions
ProNutrients Probiotic
Dietary Supplement
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 70 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2013 · Synced Oct 2, 2026, 1:47 PM EDT
Recruiting Phase 2 Interventional

Synbiotic Compound to Reduce Symptoms of Schizophrenia

NCT04226898
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Synbiotic Supplement, Inert Compound
Biological
Lead sponsor
Sheppard Pratt Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Batlimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of Probiotics to Aid in Weight Loss

NCT01445704
View directory record Official record
Conditions
Weight Loss
Interventions
Probiotics, Placebo
Dietary Supplement
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2014 · Synced Oct 2, 2026, 1:47 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Probiotics and the Gut Microbiome in Obese Hispanic Youth

NCT03115385
View directory record Official record
Conditions
Obesity, Abdominal, Adiposity
Interventions
VSL#3, Placebo
Dietary Supplement
Lead sponsor
University of Southern California
Other
Eligibility
12 Years to 18 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2017 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Measuring the Influence of Kefir on Children's Stools on Antibiotics (MILK)

NCT00481507
View directory record Official record
Conditions
Respiratory Tract Infections
Interventions
Kefir, Placebo
Other
Lead sponsor
Georgetown University
Other
Eligibility
1 Year to 5 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional

Engineering Gut Microbiome to Target Breast Cancer

NCT03358511
View directory record Official record
Conditions
Breast Cancer
Interventions
Probiotic
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2020 · Synced Oct 2, 2026, 1:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotic Administration on Mood

NCT05343533
View directory record Official record
Conditions
Depression, Sleep, Stress, Anxiety, Mood Disorders
Interventions
Probiotic
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 50 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Oct 2, 2026, 1:47 PM EDT
Terminated Phase 2Phase 3 Interventional Accepts healthy volunteers

Trenev Trio/Healthy Trinity for Symptoms of Diarrhea-predominant Irritable Bowel Syndrome (IBS) and Functional Dyspepsia

NCT01268618
View directory record Official record
Conditions
IBS-D and Functional Dyspepsia
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
Sprim Advanced Life Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
2
States / cities
Duluth, Georgia • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2011 · Synced Oct 2, 2026, 1:47 PM EDT