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ClinicalTrials.gov public records Last synced Oct 19, 2026, 7:48 PM EDT

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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Programmed Intermittent Bolus Clear all
Completed Phase 4 Interventional Results available

Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy

NCT05121168
View directory record Official record
Conditions
Pain, Acute Postoperative, Renal Stone
Interventions
Active bupivacaine 0.25% via an erector spinae plane perineural catheter, Placebo normal saline via an erector spinae plane perineural catheter
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Programmed Intermittent Epidural Bolus Time Interval and Injection Volume

NCT00417027
View directory record Official record
Conditions
Labor Pain
Interventions
Programmed Intermittent Epidural Bolus (PIEB)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 14, 2014 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Phase 4 Interventional Results available

Comparing Effectiveness of CSE Versus DPE for Labor Analgesia

NCT05068661
View directory record Official record
Conditions
Labor Pain
Interventions
Ropivacaine 0.1% Injectable Solution, Bupivacaine 0.25% Injectable Solution
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 6, 2024 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Programmed Intermittent Bolus Dosing Versus Continuous Epidural Infusion for Epidural Analgesia in Abdominal Surgery.

NCT03307174
View directory record Official record
Conditions
Pain, Acute
Interventions
Bupivacaine, Fentanyl
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Oct 19, 2026, 7:48 PM EDT
Recruiting Phase 4 Interventional

Cryo Rib Fracture Study

NCT06347874
View directory record Official record
Conditions
Rib Fractures
Interventions
Cryoablation, ESP Catheter
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Goal-directed Labor Epidural Analgesia Maintenance

NCT05255263
View directory record Official record
Conditions
Labor Onset and Length Abnormalities
Interventions
PIEB, CEI
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Oct 19, 2026, 7:48 PM EDT
Terminated Phase 4 Interventional Results available

PIEB vs CEI for Labor Analgesia: An MLAC Study

NCT02573597
View directory record Official record
Conditions
Pregnancy
Interventions
Bupivacaine, Sufentanil
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Phase 4 Interventional

Paravertebral Block to Reduce the Incidence of New Onset Atrial Fibrillation After Cardiac Surgery

NCT04472299
View directory record Official record
Conditions
New Onset Atrial Fibrillation, Anesthesia, Local, Cardiac Disease
Interventions
Ropivacaine 0.2% Injectable Solution
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Oct 19, 2026, 7:48 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Effect of Epidural Analgesia During Labor on Force of Maternal Push

NCT04888858
View directory record Official record
Conditions
Labor Pain, Analgesia, Maternal; Procedure
Interventions
Epidural analgesia (0.125% bupivacaine/2mcg fentanyl solution)
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Oct 19, 2026, 7:48 PM EDT
Not listed Not applicable Interventional

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery

NCT04770961
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
Interventions
Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 19, 2026, 7:48 PM EDT
Not yet recruiting Not applicable Interventional

A Pilot Study Comparison of Programmed Intermittent Bolus Versus Continuous Infusion

NCT07839039
View directory record Official record
Conditions
Bladder Extrophy, Surgery in Children
Interventions
Ropivacaine (Epidural analgesia) intermittent bolus, Ropivacaine (Epidural analgesia) continuous infusion, Chloroprocaine intermittent bolus, Chloroprocaine continuous infusion
Drug
Lead sponsor
Giorgio Veneziano
Other
Eligibility
Up to 18 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Continuous Versus Intermittent Bolus Infusion of Paravertebral Blocks for Thoracic Surgery

NCT03480984
View directory record Official record
Conditions
Thoracic Diseases
Interventions
Programmed Intermittent Bolus, Continuous Infusion
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 1, 2020 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Association Between Bolus Rate and the Adequacy of Labor Analgesia Using Timed-intermittent Boluses

NCT02340806
View directory record Official record
Conditions
Labor Pain, Obstetric Pain
Interventions
CADD-Solis pump (Smiths Medical)
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Oct 19, 2026, 7:48 PM EDT
Withdrawn Phase 4 Interventional

Continuous Erector Spinae Plane Blocks to Treat Postoperative Pain After Open Gynecologic Procedures Via a Low Transverse (Pfannenstiel) Incision

NCT05082155
View directory record Official record
Conditions
Surgical Incision, Pain, Postoperative, Pain, Acute
Interventions
Bupivacaine 0.25%, Normal Saline
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Oct 19, 2026, 7:48 PM EDT
Terminated Phase 4 Interventional Results available

Drug Concentration and Volume on Adequate Labor Analgesia With PIEB

NCT03553576
View directory record Official record
Conditions
Pain, Anesthesia, Labor Pain
Interventions
Low volume bolus, High volume bolus
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Oct 19, 2026, 7:48 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of PIEB vs CEI for Labor Analgesia

NCT02949271
View directory record Official record
Conditions
Labor Pain
Interventions
Programmed Intermittent Epidural Bolus, Continuous Epidural Infusion, Ropivacaine, Fentanyl
Other · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 11, 2019 · Synced Oct 19, 2026, 7:48 PM EDT