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Conditions: Posttraumatic Stress Disorder
Interventions: Prolonged exposure; Behavioral
Lead sponsor: Veterans Medical Research Foundation; Other
Eligibility: 18 Years and older
Enrollment: 175 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: San Diego, California

Conditions: Traumatic Injury, PTSD, Posttraumatic Stress Disorder
Interventions: Treatment as Usual, Brief Prolonged Exposure Therapy; Behavioral
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: Dallas, Texas • Temple, Texas • Milwaukee, Wisconsin

Conditions: PTSD
Interventions: Prolonged Exposure Therapy for Posttraumatic Stress Disorder; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Posttraumatic Stress Disorders, Combat Disorders
Interventions: Web-PE Therapy, Therapist-Delivered Present-Centered Therapy; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 4
States / cities: Atlanta, Georgia • Philadelphia, Pennsylvania • Killeen, Texas + 1 more

Conditions: Post-traumatic Stress Disorder
Interventions: ketamine-enhanced prolonged exposure; Drug
Lead sponsor: Minneapolis Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Nightmares, Insomnia, Posttraumatic Stress Disorder
Interventions: PTSD + IRT/CBT-I, PTSD + Supportive Care Therapy; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: San Diego, California

Conditions: PTSD - Post Traumatic Stress Disorder, Insomnia, TBI (Traumatic Brain Injury)
Interventions: Suvorexant, Placebo, Prolonged Exposure Therapy for Primary Care (PE-PC); Drug · Behavioral
Lead sponsor: Northern California Institute of Research and Education; Other
Eligibility: 18 Years to 75 Years
Enrollment: 142 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Posttraumatic Stress Disorder, PTSD
Interventions: Modular Cognitive Processing Therapy, Modular Prolonged Exposure Therapy, Step Down Treatment, Digital Interventions, Cognitive Processing Therapy (CPT), Prolonged Exposure (PE); Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Augusta, Georgia • Ann Arbor, Michigan • Battle Creek, Michigan + 1 more

Conditions: Post Traumatic Stress Disorder
Interventions: 3,4-Methylenedioxymethamphetamine (MDMA), Placebo, Massed Prolonged Exposure (PE); Drug · Behavioral
Lead sponsor: Emory University; Other
Eligibility: 21 Years to 70 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Post Traumatic Stress Disorder
Interventions: Prolonged Exposure for Primary Care (PE-PC), EAP Treatment as Usual (TAU); Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 410 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 14
States / cities: San Diego, California • Carrollton, Georgia • Ann Arbor, Michigan + 9 more

Conditions: PTSD
Interventions: RESCUE, Prolonged Exposure; Behavioral
Lead sponsor: Charleston Research Institute; Other
Eligibility: 18 Years to 65 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: Massed Prolonged Exposure, Intensive Outpatient Prolonged Exposure; Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years to 65 Years
Enrollment: 234 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 4
States / cities: Fort Hood, Texas • San Antonio, Texas • Waco, Texas

Conditions: PTSD
Interventions: Estradiol, Placebo oral tablet, Prolonged Exposure (PE) therapy; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Houston, Texas

Conditions: Post Traumatic Stress Disorder
Interventions: DCS (D-Cycloserine ) + Prolonged Imaginal Exposure, DCS (D-Cycloserine ) + Virtual Reality Exposure, Placebo + Prolonged Imaginal Exposure, Placebo (sugar pill) + Virtual Reality Exposure; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2018
U.S. locations: 5
States / cities: Long Beach, California • Los Angeles, California • Atlanta, Georgia + 2 more

Conditions: PTSD
Interventions: Group PE; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Battle Creek, Michigan

Conditions: Post-traumatic Stress Disorder, Suicide, Self-injurious Behavior
Interventions: Dialectical Behavior Therapy, Dialectical Behavior Therapy Prolonged Exposure protocol; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 12 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Combat Disorders, Post-traumatic Stress Disorder
Interventions: Prolonged Exposure Therapy (PE), Relaxation Training (RT); Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 60 Years and older · Male only
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: San Diego, California

Conditions: Posttraumatic Stress Disorder, PTSD, Anxiety, Depression
Interventions: Transcranial Direct Current Stimulation (tDCS), Prolonged Exposure Therapy; Device · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Stress Disorders, Post-Traumatic, Anxiety Disorders, Mental Disorder, Traumatic Disorder
Interventions: Prolonged Exposure; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 109 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: PTSD, Post Traumatic Stress Disorder
Interventions: Traditional Exposure Therapy (ET) Treatment, Stepwise Augmented Reality (AR) Component with Traditional Exposure Treatment for Nonresponders; Behavioral
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: PTSD
Interventions: trauma-focused treatment; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 3
States / cities: Boston, Massachusetts • Charleston, South Carolina • Madison, Wisconsin

Conditions: Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
Interventions: Brief Prolonged Exposure Therapy, Treatment as Usual; Behavioral
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Post Traumatic Stress Disorder
Interventions: Hydrocortisone augmented Prolonged Exposure Therapy, Prolonged exposure therapy with placebo administration; Other
Lead sponsor: Bronx VA Medical Center; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2011
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: PTSD, Alcoholism
Interventions: Integrated Prolonged Exposure Therapy, Seeking Safety; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: San Diego, California

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In-Home Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD)

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

Circadian Influence on Prolonged Exposure Therapy for PTSD

A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel

Ketamine and Prolonged Exposure in PTSD

Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life

Suvorexant 3 - PE-PC

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

MDMA-Assisted Massed Exposure Therapy for PTSD

Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

Evaluating the Feasibility of RESCUE: An Adjunctive HAI-Based Intervention for Veterans With PTSD

Project Remission: Maximizing Outcomes With Intensive Treatments for Combat-Related PTSD

Estrogen and Fear in PTSD

Enhancing Exposure Therapy for Post Traumatic Stress Disorder (PTSD): Virtual Reality and Imaginal Exposure With a Cognitive Enhancer

Optimizing Treatment Response in VA Specialized Intensive/Inpatient PTSD Programs

Effectiveness of PTSD Treatment For Suicidal and Multi-Diagnostic Clients

Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder

TDCS-Augmented Prolonged Exposure Therapy

Peer Social Support During In Vivo Exposure for PTSD

Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

Written Exposure Therapy Versus Prolonged Exposure: a Non-inferiority Trial

Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury

A Randomized Clinical Trial of Hydrocortisone Augmentation of Prolonged Exposure

Integrated Alcohol Disorder and PTSD Treatment