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ClinicalTrials.gov public records Last synced Oct 16, 2026, 11:08 PM EDT

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Showing 1–14 of 14 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Prolonged exposure therapy with placebo administration Clear all

Conditions: Posttraumatic Stress Disorder
Interventions: D-Cycloserine, Placebo; Drug · Other
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Posttraumatic Stress Disorder
Interventions: Paroxetine, Prolonged Exposure Therapy; Drug · Behavioral
Lead sponsor: Research Foundation for Mental Hygiene, Inc.; Other
Eligibility: 18 Years to 70 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Post Traumatic Stress Disorder
Interventions: Hydrocortisone augmented Prolonged Exposure Therapy, Prolonged exposure therapy with placebo administration; Other
Lead sponsor: Bronx VA Medical Center; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2011
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: PTSD, Alcohol Use Disorder
Interventions: 40 IU Intranasal Oxytocin, Placebo, Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure; Drug · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 175 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: PTSD - Post Traumatic Stress Disorder, Insomnia, TBI (Traumatic Brain Injury)
Interventions: Suvorexant, Placebo, Prolonged Exposure Therapy for Primary Care (PE-PC); Drug · Behavioral
Lead sponsor: Northern California Institute of Research and Education; Other
Eligibility: 18 Years to 75 Years
Enrollment: 142 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Post Traumatic Stress Disorder
Interventions: DCS (D-Cycloserine ) + Prolonged Imaginal Exposure, DCS (D-Cycloserine ) + Virtual Reality Exposure, Placebo + Prolonged Imaginal Exposure, Placebo (sugar pill) + Virtual Reality Exposure; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2018
U.S. locations: 5
States / cities: Long Beach, California • Los Angeles, California • Atlanta, Georgia + 2 more

Conditions: Post Traumatic Stress Disorder
Interventions: 3,4-Methylenedioxymethamphetamine (MDMA), Placebo, Massed Prolonged Exposure (PE); Drug · Behavioral
Lead sponsor: Emory University; Other
Eligibility: 21 Years to 70 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Posttraumatic Stress Disorder
Interventions: Placebo capsule, Dronabinol 7.5 milligram oral capsule; Drug
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: PTSD
Interventions: Estradiol, Placebo oral tablet, Prolonged Exposure (PE) therapy; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Houston, Texas

Conditions: Chronic Pain, Post-traumatic Stress Disorder
Interventions: Brief Prolonged Exposure Protocol, Chronic Pain Management Treatment, Self-Care; Behavioral
Lead sponsor: The University of Texas at Arlington; Other
Eligibility: 18 Years to 70 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 4
States / cities: Arlington, Texas • Fort Sam Houston, Texas • Lackland Air Force Base, Texas + 1 more

Conditions: PTSD, Alcohol Use Disorder
Interventions: Sertraline, Placebo; Drug
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 21 Years to 65 Years
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: PTSD, Post Traumatic Stress Disorder, Suicide, Cannabis Use
Interventions: Cannabidiol (CBD) only, Placebo only, Delta-9-tetrahydrocannabinol (THC) only, THC:CBD 1:1; Drug
Lead sponsor: Leslie Lundahl; Other
Eligibility: 18 Years to 60 Years
Enrollment: 280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: PTSD
Interventions: Prolonged Exposure therapy, Hydrocortisone; Behavioral · Drug
Lead sponsor: Bronx VA Medical Center; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: PTSD
Interventions: Prolonged Exposure, Cannabidiol, placebo; Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 136 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: San Diego, California

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Virtual Reality & D-cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)

Combination Treatment for Posttraumatic Stress Disorder (PTSD) After the World Trade Center (WTC) Attack

A Randomized Clinical Trial of Hydrocortisone Augmentation of Prolonged Exposure

Oxytocin to Enhance Integrated Treatment for AUD and PTSD

Suvorexant 3 - PE-PC

Enhancing Exposure Therapy for Post Traumatic Stress Disorder (PTSD): Virtual Reality and Imaginal Exposure With a Cognitive Enhancer

MDMA-Assisted Massed Exposure Therapy for PTSD

Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study

Estrogen and Fear in PTSD

Treatment of Post-Traumatic Stress Disorder (PTSD) and Chronic Pain After Traumatic Orthopedic Injury

Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems

Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery

Cortisol Augmentation of a Psychological Treatment in Warfighters With Post Traumatic Stress Disorder (PTSD)

Cannabidiol and Prolonged Exposure