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ClinicalTrials.gov public records Last synced Oct 18, 2026, 5:46 AM EDT

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Showing 169–192 of 347 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Propofol Clear all
Completed Not applicable Interventional

Audiovisual Distraction for Patients Undergoing Total Knee or Hip Replacement Surgery

NCT03191838
View directory record Official record
Conditions
Anesthesia
Interventions
Audiovisual Distraction
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 11, 2020 · Synced Oct 18, 2026, 5:46 AM EDT
Enrolling by invitation Phase 4 Interventional Accepts healthy volunteers

Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation

NCT07161518
View directory record Official record
Conditions
Healthy Participants
Interventions
Low-intensity transcranial ultrasound, Propofol
Device · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Not applicable Interventional

Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma

NCT00214370
View directory record Official record
Conditions
Leukemia, Lymphoma
Interventions
Propofol-Fentanyl, Propofol alone
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
2 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Oct 18, 2026, 5:46 AM EDT
Terminated Phase 4 Interventional Results available

The Effects of Dexmedetomidine and Remifentanil on Carotid Patients

NCT00335972
View directory record Official record
Conditions
Carotid Artery Stenosis
Interventions
Remifentanil, Dexmedetomidine
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
50 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2017 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study to Assess the Amnesic Properties of Propofol in Pediatric Patients

NCT02278003
View directory record Official record
Conditions
Pediatric Pateints, Amnesic Properties of Propofol
Interventions
memory test, Propofol
Other · Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
4 Years to 14 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Oct 18, 2026, 5:46 AM EDT
Terminated Phase 4 Interventional Results available

PROUD Study - Preventing Opioid Use Disorders

NCT04766996
View directory record Official record
Conditions
Anesthesia, Opioid Use
Interventions
Guided mindfulness exercises, Self-administered aromatherapy, Baby aspirin, Tylenol/Acetaminophen, Pregabalin, Prednisone, Meloxicam, Prilosec, Tramadol, Voltaren, Zofran, Pepcid, Reglan, Versed, Lidocaine, Propofol, Ancef, Tranexamic Acid (TXA), Decadron, Bupivacaine hydrochloride, Toradol
Behavioral · Other · Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients

NCT02548923
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Bispectral Index (BIS™) and Levels of Sedation With Common Inhalational Anesthetics in Healthy Volunteers (OLIVER)

NCT04602546
View directory record Official record
Conditions
Anesthesia
Interventions
BIS Complete Monitoring System
Device
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years to 60 Years
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
3
States / cities
San Francisco, California • Durham, North Carolina • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery

NCT01592708
View directory record Official record
Conditions
Post-operative Nausea, Post-operative Vomiting, Nausea Persistent
Interventions
Antiemetic anesthesia protocol
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
15 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2014 · Synced Oct 18, 2026, 5:46 AM EDT
Withdrawn Phase 4 Interventional

GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture

NCT03226080
View directory record Official record
Conditions
Hip Fractures, Anesthesia, Spinal, Anesthesia, General, Neuromuscular Blockade
Interventions
Rocuronium, Sugammadex, Normal saline
Drug
Lead sponsor
Loyola University
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Oct 18, 2026, 5:46 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Neural and Antidepressant Effects of Propofol (Phase 2)

NCT03923361
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Diprivan
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 18, 2019 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Phase 2 Interventional Results available

Local Anesthetic Cream in Younger Patients Undergoing Lumbar Punctures

NCT01516684
View directory record Official record
Conditions
Malignant Neoplasm
Interventions
placebo administration, EMLA, propofol, fentanyl citrate
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
Up to 22 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Phase 4 Interventional Results available

Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation

NCT00997126
View directory record Official record
Conditions
Sedation
Interventions
Propofol, Alfentanil
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 27, 2017 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Low- Dose Propofol Infusion as an Abortive Treatment for Migraine Headaches in Pediatric Patients

NCT02485418
View directory record Official record
Conditions
Migraine Headache
Interventions
Propofol
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
7 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Phase 4 Interventional Results available

Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department

NCT02404610
View directory record Official record
Conditions
Pain
Interventions
Moderate Procedural Sedation with a sedative medication., Deep Procedural Sedation with a sedative medication., propofol
Procedure · Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 30, 2021 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

NCT02625181
View directory record Official record
Conditions
Postoperative Nausea and Vomiting
Interventions
Automated recommendation at the start of the case, Automated notification at the start of surgery, Preoperative recommendations: by email, Automated notification at the end of surgery, Anesthesia Information Management System (AIMS), Perioperative Data Warehouse (PDW), General anesthesia, Elective surgery, Propofol, Sevoflurane, Isoflurane, Desflurane, Scopolamine, Droperidol, Haloperidol, Dexamethasone, Promethazine, Meclizine, Aprepitant, Metoclopramide, Fentanyl, Sufentanil, Alfentanil, Remifentanil, Morphine, Meperidine, Hydromorphone, Methadone, Oxycodone, Oxymorphone, Hydrocodone, Ketamine, Ondansetron, Granisetron, Dolasetron mesylate, Palonosetron, Tropisetron, Ramosetron
Procedure · Device · Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
27,034 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 7, 2019 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery

NCT05252858
View directory record Official record
Conditions
Opioid Use, Pain, Post Operative
Interventions
nCAP Signal Relief Patch, Standard of Care
Device · Other
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Oct 18, 2026, 5:46 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Combined Ketamine/Propofol for Emergency Department Procedural Sedation

NCT01126957
View directory record Official record
Conditions
Procedural Sedation and Analgesia
Interventions
Ketamine, Placebo, Fentanyl, Propofol
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
1 Year and older
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Asleep Versus Awake Deep Brain Stimulation Surgery

NCT02424929
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Sedation, Original Surgery
Procedure
Lead sponsor
Providence Medical Research Center
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2025
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 18, 2026, 5:46 AM EDT
Completed Phase 4 Interventional Results available

Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery

NCT02546765
View directory record Official record
Conditions
Delirium
Interventions
IV acetaminophen & IV propofol, IV acetaminophen & IV dexmedetomidine, IV propofol & placebo, IV dexmedetomidine & placebo
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Oct 18, 2026, 5:46 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Prospective Study of Induction Medications Used in the Trauma RSI

NCT04291521
View directory record Official record
Conditions
Trauma, Rapid Sequence Intubation
Interventions
Ketamine, Etomidate, Propofol
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 18, 2026, 5:46 AM EDT
Enrolling by invitation Not applicable Interventional

INtubation With Sedation Only to Preserve Independent Respiratory Effort Trial

NCT07845305
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Intubation with a sedative medication only, Intubation with a sedative medication and neuromuscular blockade agent
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 18, 2026, 5:46 AM EDT
Terminated Phase 4 Interventional Results available

The Effects of Dexmedetomidine Dose on Motor Evoked Potentials

NCT03378973
View directory record Official record
Conditions
Spinal Fusion
Interventions
Dexmedetomidine
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Oct 18, 2026, 5:46 AM EDT
Terminated Not applicable Interventional

Helping Stroke Patients With ThermoSuit Cooling

NCT02453373
View directory record Official record
Conditions
Stroke, Brain Ischemia
Interventions
ThermoSuit Cooling Induction, Magnesium Sulfate, tPA, Propofol, Etomidate, Neurothrombectomy
Device · Drug · Procedure
Lead sponsor
Life Recovery Systems
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
4
States / cities
New Orleans, Louisiana • Danville, Pennsylvania • Wilkes-Barre, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Oct 18, 2026, 5:46 AM EDT