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Showing 1–24 of 128 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Propofol Induction Clear all
Completed Not applicable Interventional

Shaping Anesthetic Techniques to Reduce Post-operative Delirium

NCT03133845
View directory record Official record
Conditions
Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
Interventions
Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic, Muscle relaxant during maintenance anesthesia, Pain control with fentanyl, Bispectral Index (BIS) monitoring for depth of anesthesia, Spinal Anesthesia, Midazolam administered during spinal anesthesia, Cerebrospinal fluid collection, Administration of intrathecal morphine
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 3 Interventional

Comparison of Paravertebral Block With General Anesthesia in Patients Undergoing Breast Cancer Surgery

NCT00645138
View directory record Official record
Conditions
Breast Cancer
Interventions
Paravertebral Block, General Anesthesia
Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2011 · Synced Sep 3, 2026, 3:13 AM EDT
Terminated Not applicable Interventional

Helping Stroke Patients With ThermoSuit Cooling

NCT02453373
View directory record Official record
Conditions
Stroke, Brain Ischemia
Interventions
ThermoSuit Cooling Induction, Magnesium Sulfate, tPA, Propofol, Etomidate, Neurothrombectomy
Device · Drug · Procedure
Lead sponsor
Life Recovery Systems
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
4
States / cities
New Orleans, Louisiana • Danville, Pennsylvania • Wilkes-Barre, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 2 Interventional Results available

The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction

NCT02554253
View directory record Official record
Conditions
Cognitive Disorders, Delirium, Acute Kidney Injury
Interventions
Ketamine, Propofol
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
75 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 14, 2022 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia

NCT03820388
View directory record Official record
Conditions
Surgery
Interventions
Propofol 2mg/kg, Etomidate 0.3 mg/kg, Propofol 1 mg/kg, Etomidate 0.15 mg/kg
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Not applicable Interventional Results available

The Effect on Cognition of Terminating ECT Induced Seizures With Propofol

NCT00616759
View directory record Official record
Conditions
Major Depression
Interventions
electroconvulsive therapy, electroconvulsive therapy plus propofol, propofol
Procedure · Drug
Lead sponsor
Loma Linda University
Other
Eligibility
45 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2021 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Analyzing the Relationship Between Speed Propofol is Given and Low Blood Pressure

NCT05415436
View directory record Official record
Conditions
Hypotension on Induction
Interventions
Propofol slow administration
Other
Lead sponsor
University of Toledo
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Sep 3, 2026, 3:13 AM EDT
Terminated Phase 2 Interventional Results available

Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial

NCT05378113
View directory record Official record
Conditions
Injection Site Irritation
Interventions
Ondansetron, Lidocaine
Drug
Lead sponsor
Emory University
Other
Eligibility
2 Years to 17 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Perioperative Ketamine for Pain With Gastric Bypass

NCT03448068
View directory record Official record
Conditions
Laparoscopic Gastric Bypass Surgery, Ketamine
Interventions
Ketamine, Standard therapy
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 69 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Sep 3, 2026, 3:13 AM EDT
Enrolling by invitation Phase 1 Interventional Accepts healthy volunteers

Induction of Dreaming With EEG and Anesthesia in Healthy Adults

NCT07198711
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Propofol - Emergence-from-LOR Protocol, Propofol - Light Sedation Protocol
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 3, 2026, 3:13 AM EDT
Recruiting Phase 2 Interventional

Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea

NCT00695214
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Propofol sedation
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2035
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial

NCT02105415
View directory record Official record
Conditions
Critical Illness
Interventions
Ketamine / Propofol Admixture, Etomidate
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 15, 2020 · Synced Sep 3, 2026, 3:13 AM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Individual Cerebral Hemodynamic Oxygenation Relationships - ICHOR 4

NCT07103616
View directory record Official record
Conditions
Anesthesia; Reaction, Anesthesia
Interventions
Randomization of Propofol or Dexmedetomidine
Drug
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
Up to 7 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Sep 3, 2026, 3:13 AM EDT
Terminated Phase 2 Interventional Results available

Airway Dimension Study in Children Undergoing MRI Sedated With Propofol and Dexmedetomidine

NCT01505933
View directory record Official record
Conditions
Airway Remodeling
Interventions
Dexmedetomidine, propofol
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
2 Years to 5 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Sep 3, 2026, 3:13 AM EDT
Terminated Not applicable Interventional Results available

Isoflurane Preconditioning for Liver Resections

NCT01031550
View directory record Official record
Conditions
Liver Disease
Interventions
isoflurane, propofol
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 19, 2017 · Synced Sep 3, 2026, 3:13 AM EDT
Completed No phase listed Observational

Heart Rate Changes With Propofol

NCT01355432
View directory record Official record
Conditions
Surgical Patients
Interventions
Observation
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
1 Year and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 1, 2012 · Synced Sep 3, 2026, 3:13 AM EDT
Not listed Phase 4 Interventional

In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?

NCT01576770
View directory record Official record
Conditions
Pain on Propofol IV Injection
Interventions
lidocaine/tetracaine transdermal patch (NDC 43469-864-01), Gebauer's Ethyl Chloride
Device · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
6 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 11, 2012 · Synced Sep 3, 2026, 3:13 AM EDT
Recruiting No phase listed Observational

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

NCT07222007
View directory record Official record
Conditions
Critically Ill, Intubation Complication, Oxygenation, Airway Management, Propofol, Ketamine
Interventions
induction type for intubation in ICU
Procedure
Lead sponsor
Zeliha Alicikus
Government
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparison of Inhalation vs. Intravenous Induction

NCT02331108
View directory record Official record
Conditions
Hypothermia
Interventions
Selection of anesthetic induction technique
Drug
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
331 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Dose-Finding and Human Abuse Potential Study Of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users

NCT05614544
View directory record Official record
Conditions
General Anesthesia
Interventions
HSK3486, Propofol, Placebo
Drug
Lead sponsor
Haisco-USA Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Efficacy and Safety Study of Propofol Infusion for Refractory Chronic Primary Insomnia

NCT02043977
View directory record Official record
Conditions
Insomnia, Sleep Disorder, Dyssomnia
Interventions
propofol injectable emulsion
Drug
Lead sponsor
Life Extension Foundation Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Aug 29, 2016 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Not applicable Interventional Results available

A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters

NCT01065350
View directory record Official record
Conditions
Blood Pressure
Interventions
Propofol, Ketamine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 60 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 2, 2013 · Synced Sep 3, 2026, 3:13 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Pilot Analysis of the Association Between Anesthesia Induction Dosing and AKI in the Elderly Population

NCT03699696
View directory record Official record
Conditions
Acute Kidney Injury, Hypotension, Anesthesia; Adverse Effect
Interventions
Propofol
Drug
Lead sponsor
Yale University
Other
Eligibility
65 Years and older
Enrollment
541 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 23, 2019 · Synced Sep 3, 2026, 3:13 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Effect of Opioid Free Anesthetic on Post-Operative Opioid Consumption After Laparoscopic Bariatric Surgery

NCT04081545
View directory record Official record
Conditions
Opioid Use, Unspecified, Bariatric Surgery Candidate, Anesthesia
Interventions
Opioid Anesthetics, Non Opioid Analgesics
Drug
Lead sponsor
Christine Oryhan
Other
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Sep 3, 2026, 3:13 AM EDT