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ClinicalTrials.gov public records Last synced Oct 23, 2026, 8:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 147 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Propofol Sedation Clear all
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Ketamine and Propofol NeuroImaging

NCT07294092
View directory record Official record
Conditions
Anesthesia, Pain
Interventions
Propofol, Ketamine, Peripheral Nerve Stimulation
Drug · Device
Lead sponsor
Keith M Vogt
Other
Eligibility
18 Years to 59 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 23, 2026, 8:17 AM EDT
Suspended Phase 4 Interventional

Ketamine for Sedation in Severe Traumatic Brain Injury

NCT06429657
View directory record Official record
Conditions
Severe Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, Hypertensive
Interventions
Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam
Drug · Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Not applicable Interventional Results available

Sedation in Patients at Risk for Upper Airway Collapse

NCT01045122
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Propofol, Dexmedetomidine
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2015 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Phase 4 Interventional Results available

Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade

NCT01335542
View directory record Official record
Conditions
Readiness to Discharge
Interventions
Peri-Articular Injection, Epidural Pathway (PCEA+FNB)
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 85 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2022 · Synced Oct 23, 2026, 8:17 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Cannabis Use on Sedation for Oral Surgery Procedures

NCT05873465
View directory record Official record
Conditions
Cannabis Use
Interventions
Sedation with Midazolam, Fentanyl, and Propofol, Extraction of teeth
Drug · Procedure
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 23, 2026, 8:17 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Driving Skills Recovery Following Procedural Sedation for Gastrointestinal Endoscopy

NCT04350424
View directory record Official record
Conditions
Anesthesia, Psychomotor Status
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Not applicable Interventional Results available

Combining Objective and Subjective Sedation Assessment Tools

NCT00734409
View directory record Official record
Conditions
Critical Illness
Interventions
Bispectral Index (BIS) Monitor
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 29, 2013 · Synced Oct 23, 2026, 8:17 AM EDT
Completed No phase listed Observational

Race-Specific Propofol Titration to Effect for Procedural Sedation

NCT03290859
View directory record Official record
Conditions
Unconsciousness, Apnea, Postanesthetic, Sedative Overdose, Hypoxemia
Interventions
Titrate propofol monotherapy infusion to effect
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
2,780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 25, 2019 · Synced Oct 23, 2026, 8:17 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

SGA for TEE: Safe Alternative to Deep Sedation for Patients With High-risk Cardiopulmonary Disease.

NCT04939220
View directory record Official record
Conditions
Cardiopulmonary Disease
Interventions
TEE with SGA, TEE with Deep Sedation
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 120 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Oct 23, 2026, 8:17 AM EDT
Terminated Phase 1 Interventional

How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units

NCT00826553
View directory record Official record
Conditions
Delirium, Respiratory Failure
Interventions
Dexmedetomidine, GABA agonist
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 5, 2017 · Synced Oct 23, 2026, 8:17 AM EDT
Suspended Phase 2 Interventional Accepts healthy volunteers

A Study of Human Multi-Sensory Integration

NCT03498391
View directory record Official record
Conditions
Anesthesia Awareness
Interventions
Propofol, Ketamine Injectable Product
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Not applicable Interventional Results available

The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation

NCT01200433
View directory record Official record
Conditions
Intracranial Neurosurgery
Interventions
dexmedetomidine, propofol
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 14, 2016 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Phase 4 Interventional Results available

Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation

NCT01260662
View directory record Official record
Conditions
Procedural Sedation
Interventions
Propofol, 1:1 Propofol/Ketamine, 4:1 Propofol/Ketamine
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
1 Year and older
Enrollment
271 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 14, 2015 · Synced Oct 23, 2026, 8:17 AM EDT
Recruiting Phase 2 Interventional

Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea

NCT00695214
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Propofol sedation
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2035
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study

NCT03284307
View directory record Official record
Conditions
Unconsciousness, Consciousness
Interventions
Dexmedetomidine, Ketamine, Propofol, Midazolam
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 13, 2023 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Phase 4 Interventional Results available

Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans

NCT04237792
View directory record Official record
Conditions
MRI Sedation
Interventions
dexmedetomidine, propofol
Drug
Lead sponsor
Pfizer
Industry
Eligibility
1 Month to 16 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
16
States / cities
Little Rock, Arkansas • Palo Alto, California • Sacramento, California + 12 more
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Oct 23, 2026, 8:17 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Sedasys Post Approval Study Users Response to System Alarms

NCT02573818
View directory record Official record
Conditions
Conscious Sedation
Interventions
SEDASYS System
Device
Lead sponsor
Ethicon Endo-Surgery
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2017 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Phase 3 Interventional Results available

Safety and Effectiveness of a Computer-Assisted Personalized Sedation (CAPS) Device for Propofol Delivery During Endoscopy

NCT00452426
View directory record Official record
Conditions
Colonoscopy, Endoscopy, Digestive System, Conscious Sedation
Interventions
Computer-Assisted Personalized Sedation (CAPS) Device (SEDASYS® System), benzodiazepines and opioid sedation
Device · Other
Lead sponsor
Ethicon Endo-Surgery
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
7
States / cities
Washington D.C., District of Columbia • Fayetteville, North Carolina • Winston-Salem, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2011 · Synced Oct 23, 2026, 8:17 AM EDT
Terminated Phase 4 Interventional Results available

Anesthetic Techniques in EP Patients

NCT02664922
View directory record Official record
Conditions
Cardiac Disease
Interventions
Propofol, Ketamine, Remifentanil, Sevoflurane
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Phase 4 Interventional Results available

Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block

NCT02469961
View directory record Official record
Conditions
Shoulder Pain
Interventions
Dexmedetomidine, Propofol, Interscalene block
Drug · Other
Lead sponsor
Maimonides Medical Center
Other
Eligibility
21 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation

NCT00786916
View directory record Official record
Conditions
Pain
Interventions
normal saline, lidocaine
Drug
Lead sponsor
Akron Children's Hospital
Other
Eligibility
2 Years to 7 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 27, 2015 · Synced Oct 23, 2026, 8:17 AM EDT
Completed Not applicable Interventional

Music Distraction and Its Influence on Anesthetic Requirements During Elective Knee Surgery

NCT03486106
View directory record Official record
Conditions
Anesthesia; Functional, Surgery
Interventions
Music, Headphones, Propofol
Other · Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Oct 23, 2026, 8:17 AM EDT
Terminated Not applicable Interventional Results available

Intravenous Sedation Versus General Anesthesia in Patients Undergoing Minor Gynecologic Surgery

NCT01890707
View directory record Official record
Conditions
Surgery, Anesthesia, Pain
Interventions
General Anesthesia, Deep Sedation
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 2, 2020 · Synced Oct 23, 2026, 8:17 AM EDT
Recruiting Not applicable Interventional

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils

NCT06258837
View directory record Official record
Conditions
Otolaryngological Disease, Obstructive Sleep Apnea
Interventions
DISE-Directed Surgery, Adenotonsillectomy
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
2 Years to 17 Years
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Ann Arbor, Michigan • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 23, 2026, 8:17 AM EDT