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Showing 1–24 of 145 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Propofol sedation Clear all
Completed Phase 4 Interventional Results available

Stress During Deep Sedation With Propofol With and Without Alfentanil

NCT00997113
View directory record Official record
Conditions
Sedation
Interventions
propofol, alfentanil
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 24, 2014 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

Combining Objective and Subjective Sedation Assessment Tools

NCT00734409
View directory record Official record
Conditions
Critical Illness
Interventions
Bispectral Index (BIS) Monitor
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 28, 2013 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Shaping Anesthetic Techniques to Reduce Post-operative Delirium

NCT03133845
View directory record Official record
Conditions
Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
Interventions
Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic, Muscle relaxant during maintenance anesthesia, Pain control with fentanyl, Bispectral Index (BIS) monitoring for depth of anesthesia, Spinal Anesthesia, Midazolam administered during spinal anesthesia, Cerebrospinal fluid collection, Administration of intrathecal morphine
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Phase 3 Interventional

Comparison of Paravertebral Block With General Anesthesia in Patients Undergoing Breast Cancer Surgery

NCT00645138
View directory record Official record
Conditions
Breast Cancer
Interventions
Paravertebral Block, General Anesthesia
Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2011 · Synced Sep 3, 2026, 7:59 AM EDT
Recruiting Phase 3 Interventional

Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)

NCT05358535
View directory record Official record
Conditions
Anesthesia, Propofol Adverse Reaction, Etomidate Adverse Reaction, Anesthesia Complication, Anesthesia; Adverse Effect, Anesthesia; Reaction
Interventions
Admixture of propofol and etomidate at a ratio by volume of 75%/25% (P7E2), Admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7)
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Phase 4 Interventional Results available

Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure

NCT02203019
View directory record Official record
Conditions
Sepsis, Respiratory Failure, Agitation
Interventions
Propofol, Dexmedetomidine, Fentanyl
Drug
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 89 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2020 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

Nasopharyngeal Versus Nasal Cannula Oxygen Supplementation in Surgery Patients

NCT02219464
View directory record Official record
Conditions
Oxygen Administration During Deep Sedation
Interventions
Nasopharyngeal catheter, Nasal Cannula, Oxygen Supplementation, Sedation
Device · Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
16 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Phase 4 Interventional Results available

The Synergistic Effect of Dexmedetomidine on Propofol for Sedation for Pediatric Endoscopy

NCT02952222
View directory record Official record
Conditions
Anesthesia
Interventions
Dexmedetomidine, Propofol (Group P), Propofol (Group DP)
Drug
Lead sponsor
Keira Mason
Other
Eligibility
7 Years to 18 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients

NCT02548923
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 13, 2015 · Synced Sep 3, 2026, 7:59 AM EDT
Terminated Phase 4 Interventional Results available

Anesthetic Techniques in EP Patients

NCT02664922
View directory record Official record
Conditions
Cardiac Disease
Interventions
Propofol, Ketamine, Remifentanil, Sevoflurane
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Sep 3, 2026, 7:59 AM EDT
Withdrawn Not applicable Interventional

Comparison of High-flow Oxygen With or Without Nasal Positive Airway Pressure (PAP) During Propofol Sedation for Colonoscopy in an Ambulatory Surgical Center

NCT05754255
View directory record Official record
Conditions
Colonoscopy, Positive-Pressure Respiration
Interventions
Nasal Cannula, Nasal Positive Airway Pressure System
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Sep 3, 2026, 7:59 AM EDT
Terminated Phase 3 Interventional Results available

Comparing Safety and Efficacy of Dexmedetomidine and Propofol

NCT01152021
View directory record Official record
Conditions
Safety and Efficacy of Sedation Medications
Interventions
Dexmedetomidine, Propofol
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years to 11 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2019 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Phase 3 Interventional Results available

Safety and Effectiveness of a Computer-Assisted Personalized Sedation (CAPS) Device for Propofol Delivery During Endoscopy

NCT00452426
View directory record Official record
Conditions
Colonoscopy, Endoscopy, Digestive System, Conscious Sedation
Interventions
Computer-Assisted Personalized Sedation (CAPS) Device (SEDASYS® System), benzodiazepines and opioid sedation
Device · Other
Lead sponsor
Ethicon Endo-Surgery
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
7
States / cities
Washington D.C., District of Columbia • Fayetteville, North Carolina • Winston-Salem, North Carolina + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2011 · Synced Sep 3, 2026, 7:59 AM EDT
Enrolling by invitation Phase 1 Interventional Accepts healthy volunteers

Induction of Dreaming With EEG and Anesthesia in Healthy Adults

NCT07198711
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Propofol - Emergence-from-LOR Protocol, Propofol - Light Sedation Protocol
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 3, 2026, 7:59 AM EDT
Recruiting Phase 2 Interventional

Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea

NCT00695214
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Propofol sedation
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2035
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 3, 2026, 7:59 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Cannabis Use on Sedation for Oral Surgery Procedures

NCT05873465
View directory record Official record
Conditions
Cannabis Use
Interventions
Sedation with Midazolam, Fentanyl, and Propofol, Extraction of teeth
Drug · Procedure
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 3, 2026, 7:59 AM EDT
Terminated Phase 2 Interventional Results available

Airway Dimension Study in Children Undergoing MRI Sedated With Propofol and Dexmedetomidine

NCT01505933
View directory record Official record
Conditions
Airway Remodeling
Interventions
Dexmedetomidine, propofol
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
2 Years to 5 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Phase 2 Interventional

Acute Neurological ICU Sedation Trial (ANIST)

NCT00390871
View directory record Official record
Conditions
Sedation
Interventions
Fentanyl/Dexmedetomidine, Fentanyl/Propofol, Fentanyl
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 15, 2019 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation

NCT03255824
View directory record Official record
Conditions
Anesthesia
Interventions
Dexmedetomidine and Midazolam, Propofol, Midazolam, and Fentanyl
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 35 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

Probability Ramp Control of Propofol for EGD

NCT01838304
View directory record Official record
Conditions
Gastrointestinal Disease
Interventions
Probability ramp control, Monitoring
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sedation and Pain (The Effect of IV Sedation on Pain Perception)

NCT00853333
View directory record Official record
Conditions
Pain
Interventions
dexmedetomidine, midazolam, propofol
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 40 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 25, 2014 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Patient-Controlled Sedation Versus Anesthesiologist-Administered Sedation

NCT00868920
View directory record Official record
Conditions
Colonoscopy
Interventions
patient control of pump, anesthesiologist controlled sedation
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 29, 2017 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bispectral Index and Levels of Sedation With Propofol With/Without Remifentanil in Healthy Volunteers (SONORA)

NCT04466384
View directory record Official record
Conditions
Anesthesia
Interventions
BIS
Device
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2022 · Synced Sep 3, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Intraoperative VR for Older Patients Undergoing TKA

NCT04748549
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Virtual Reality Immersive Relaxation, Immersive Audio Experience, Sham Virtual Reality Experience
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 3, 2026, 7:59 AM EDT