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ClinicalTrials.gov public records Last synced Oct 2, 2026, 2:31 AM EDT

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Showing 25–48 of 131 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Pulmonary vein isolation ablation Clear all
Not listed Not applicable Interventional

Left Atrial Posterior Wall and PV Isolation Using Cryoballoon for Treatment of Persistent AF

NCT04505163
View directory record Official record
Conditions
Persistent Atrial Fibrillation
Interventions
Standard Cryoballoon Pulmonary Vein Isolation (PVI), Cryoballoon PVI + Posterior Wall Isolation
Procedure · Device
Lead sponsor
Dignity Health Medical Foundation
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
11
States / cities
Sacramento, California • Fort Collins, Colorado • Washington D.C., District of Columbia + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Phase 2 Interventional

Combined Treatment of Arterial Hypertension and Atrial Fibrillation

NCT01897545
View directory record Official record
Conditions
Arterial Hypertension, Atrial Fibrillation
Interventions
Circumferential PV isolation, PV isolation+renal denervation
Procedure
Lead sponsor
Meshalkin Research Institute of Pathology of Circulation
Network
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2013 · Synced Oct 2, 2026, 2:31 AM EDT
Active, not recruiting Not applicable Interventional

Treatment of PAF With the Synaptic System

NCT05905835
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Synaptic Cryoablation System
Device
Lead sponsor
Synaptic Medical Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
10
States / cities
Phoenix, Arizona • Jonesboro, Arkansas • Los Angeles, California + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Oct 2, 2026, 2:31 AM EDT
Not listed Not applicable Interventional

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

NCT02513797
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
LARIAT + PVI, Pulmonary Vein Isolation
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
53
States / cities
Phoenix, Arizona • La Jolla, California • Los Angeles, California + 44 more
Source: ClinicalTrials.gov public record
Updated Sep 5, 2021 · Synced Oct 2, 2026, 2:31 AM EDT
Not listed No phase listed Observational

Does Atrial Fibrillation (AF) Termination Without Additional Ablation Influence Outcome?

NCT01696344
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
PVAI, PVAI + ablation of extraPV triggers
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Oct 2, 2026, 2:31 AM EDT
Terminated Not applicable Interventional

Renal Denervation Therapy in Hypertensive Patients Undergoing A-Fib Ablation

NCT01952743
View directory record Official record
Conditions
Atrial Fibrillation, Hypertension
Interventions
AF ablation with Renal Denervation, AF ablation alone
Procedure
Lead sponsor
Siva Mulpuru
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 22, 2017 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Phase 3 Interventional

First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Persistent Atrial Fibrillation Treatment (RAAFT-3)

NCT04037397
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Anti Arrhythmics, Pulmonary Vein Isolation performed by Radio Frequency Catheter Ablation
Drug · Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
5
States / cities
Tucson, Arizona • The Bronx, New York • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Oct 2, 2026, 2:31 AM EDT
Terminated Phase 4 Interventional Results available

Catheter Ablation vs. Medical Therapy in Congested Hearts With AF

NCT02686749
View directory record Official record
Conditions
Congestive Heart Failure, Left Ventricular Failure, Atrial Fibrillation
Interventions
Catheter Ablation, FDA approved anti arrhythmic drug
Device · Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
6
States / cities
Hartford, Connecticut • Akron, Ohio • Cleveland, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Oct 2, 2026, 2:31 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Second Study to Assess Different Ablation Strategies in Achieving Long-Term Arrhythmia Control in Patients With Persistent or Long Standing Persistent Atrial Fibrillation

NCT02019238
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Pulmonary Vein Isolation procedure
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 22, 2016 · Synced Oct 2, 2026, 2:31 AM EDT
Active, not recruiting Not applicable Interventional

CONVERGE Post-Approval Study (PAS)

NCT05393180
View directory record Official record
Conditions
Chronic Atrial Fibrillation
Interventions
Epicardial And Endocardial RF Ablation For The Treatment Of Symptomatic Long-standing Persistent AF
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
12
States / cities
San Francisco, California • Hartford, Connecticut • Clearwater, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 2, 2026, 2:31 AM EDT
Active, not recruiting No phase listed Observational

REView of ProcEdural FactoRs and Outcomes After Atrial Fibrillation Ablation With Active Esophageal COOLing: A Sub-Study of the REAL AF Registry

NCT06354777
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Atrial Ablation
Device
Lead sponsor
Heart Rhythm Clinical and Research Solutions, LLC
Other
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
6
States / cities
Chandler, Arizona • Indianapolis, Indiana • Royal Oak, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 2, 2026, 2:31 AM EDT
Not listed Not applicable Interventional

Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation

NCT01672138
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Long-standing Persistent Atrial Fibrillation
Interventions
Pulmonary Vein Antrum Isolation, scar homogenization, Non-PV triggers ablation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2018 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Phase 3 Interventional Results available

Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation

NCT01898221
View directory record Official record
Conditions
Ventricular Tachycardia, Atrial Fibrillation
Interventions
Ethanol, Ablation
Drug · Procedure
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 85 Years
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
12
States / cities
Phoenix, Arizona • Los Angeles, California • San Diego, California + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Not applicable Interventional

POLARx Post Approval Study (POLARx PAS)

NCT06170606
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Boston Scientific Cardiac Cryoablation System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
11
States / cities
Gilbert, Arizona • Phoenix, Arizona • Tucson, Arizona + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 2, 2026, 2:31 AM EDT
Terminated Not applicable Interventional

Strategies in Patients Undergoing Repeat AF Ablation

NCT05185310
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Ablation
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 9, 2024 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Not applicable Interventional Results available

ABLATE Post Approval Study - Synergy Ablation Lesions for Non-Paroxysmal Atrial Fibrillation

NCT01694563
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Interventions
Synergy Ablation System
Device
Lead sponsor
AtriCure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
49
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Los Angeles, California + 41 more
Source: ClinicalTrials.gov public record
Updated Oct 9, 2019 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Not applicable Interventional

Evaluation of Conventional Ablation With or Without Focal Impulse and Rotor Modulation to Eliminate Human AF

NCT02456233
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Conventional AF Ablation with PVI, FIRM-guided ablation plus PVI
Procedure
Lead sponsor
Stanford University
Other
Eligibility
22 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
2
States / cities
San Diego, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of VISITAG SURPOINT™ Module With External Processing Unit (EPU)

NCT03624881
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Catheter ablation with EPU
Device
Lead sponsor
Biosense Webster, Inc.
Industry
Eligibility
18 Years and older
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
41
States / cities
Birmingham, Alabama • Huntsville, Alabama • Little Rock, Arkansas + 34 more
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Not applicable Interventional Results available

DiamondTemp™ Ablation System for the Treatment of Paroxysmal Atrial Fibrillation

NCT03334630
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation, Atrial Fibrillation
Interventions
DiamondTemp Ablation catheter, TactiCath Quartz Ablation catheter
Device
Lead sponsor
Medtronic Cardiac Ablation Solutions
Industry
Eligibility
18 Years and older
Enrollment
482 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
14
States / cities
Birmingham, Alabama • Los Angeles, California • Redwood City, California + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 2, 2026, 2:31 AM EDT
Terminated Not applicable Interventional

Comparison of PVI Plus Catheter Ablation or PVI Alone for the Treatment of AFib for Patients With Paroxysmal Atrial Fibrillation

NCT03115554
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
PVI Plus Catheter Ablation, PVI Alone
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 3, 2024 · Synced Oct 2, 2026, 2:31 AM EDT
Recruiting No phase listed Observational

Repeatable Evaluation of Functional Intra-procedural Signals for Effect in Pulsed Field Ablation REFINE-PFA

NCT07275151
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Pulmonary vein isolation ablation
Device
Lead sponsor
CathVision ApS
Industry
Eligibility
21 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Ypsilanti, Michigan • Paramus, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Not applicable Interventional

Timing of Direct Current Cardioversion (DCC) in Patients Undergoing Ablation of Persistent/Permanent Atrial Fibrillation

NCT02429648
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
DCC first then PVI, PVI then DCC after
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 10, 2017 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Not applicable Interventional Results available

Assessing Arrhythmias After Ablation Using Implantable Recorders

NCT01176617
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Reveal XT implantable loop recorder
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 2, 2026, 2:31 AM EDT
Completed Not applicable Interventional Results available

Boston Scientific's Cryoballoon in the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation

NCT04133168
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Boston Scientific Cardiac Cryoablation System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
30
States / cities
Phoenix, Arizona • Tucson, Arizona • Jonesboro, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Oct 2, 2026, 2:31 AM EDT