Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 26, 2026, 9:47 PM EDT

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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Conditions
Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency
Interventions
Pyridoxal Phosphate
Drug
Lead sponsor
Medicure
Industry
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
6
States / cities
Birmingham, Alabama • Palo Alto, California • Aurora, Colorado + 3 more
Conditions
Chronic Pain
Interventions
Inflammation Support Formula, Nerve Health Formula, Redox Support Formula
Dietary Supplement
Lead sponsor
Ethos Research & Development
Industry
Eligibility
18 Years to 75 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newport, Kentucky
Recruiting Phase 1 Interventional Accepts healthy volunteers

B-Complex: A Nutraceutical SANS Countermeasure

NCT05366933
Conditions
Optic Disc Edema, Endothelial Dysfunction
Interventions
Vitamin B-Complex Supplement
Drug
Lead sponsor
National Aeronautics and Space Administration (NASA)
Federal
Eligibility
20 Years to 100 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2032
U.S. locations
1
States / cities
Houston, Texas
Conditions
Gyrate Atrophy
Interventions
Not listed
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
Not listed
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1978 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Multiple Sclerosis
Interventions
Mangafodipir (Teslascan)
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 70 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
COVID-19, Acute Respiratory Distress Syndrome, SARS-CoV-2, Hypoxemia
Interventions
Rejuveinix (RJX) Active Comparator, Placebo Comparator
Drug
Lead sponsor
Reven Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Houston, Texas • New Braunfels, Texas
Conditions
Advanced Metastatic (Stage IV) Colorectal Cancer
Interventions
PledOx (2 µmol/kg), PledOx (5 µmol/kg), PledOx (10 µmol/kg), Placebo (0,9% NaCl)
Drug
Lead sponsor
Egetis Therapeutics AB (publ)
Industry
Eligibility
18 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
6
States / cities
La Jolla, California • Bethesda, Maryland • Chattanooga, Tennessee + 3 more
Conditions
Diabetic Peripheral Neuropathy
Interventions
Metanx® (Oral L-methylfolate, Methylcobalamin and Pyridoxal 5'-phosphate)
Other
Lead sponsor
Carolina Musculoskeletal Institute
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
1
States / cities
Aiken, South Carolina
Not listed No phase listed Observational Accepts healthy volunteers

Metanx® P.L.U.S. Program (Progress Through Learning, Understanding & Support)

NCT01368549
Conditions
Diabetic Peripheral Neuropathy
Interventions
Metanx® (a medical food)
Other
Lead sponsor
Pamlab, L.L.C.
Industry
Eligibility
18 Years to 80 Years
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Montgomery, Alabama
Conditions
Hemorrhagic Shock
Interventions
Poly SFH-P Injection
Drug
Lead sponsor
Northfield Laboratories
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
32
States / cities
San Diego, California • Denver, Colorado • Newark, Delaware + 25 more
Completed No phase listed Observational Accepts healthy volunteers

Administrative Claims Analysis of Metanx® in Diabetic Peripheral Neuropathy

NCT01247558
Conditions
Diabetic Peripheral Neuropathy (DPN)
Interventions
Metanx® (a medical food), Not treated with Metanx®
Other
Lead sponsor
Pamlab, L.L.C.
Industry
Eligibility
25 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Wilmington, Delaware
Conditions
Type 2 Diabetic Peripheral Neuropathy (DPN)
Interventions
Metanx (a medical food), Metanx placebo
Other
Lead sponsor
Pamlab, Inc.
Industry
Eligibility
25 Years to 80 Years
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
6
States / cities
Birmingham, Alabama • New Orleans, Louisiana • Omaha, Nebraska + 3 more
Conditions
Safety, Tolerance
Interventions
Crystal Light (once serving), Liquid IV with amino acids (one serving), Liquid IV with amino acids (two servings), Liquid IV with amino acids (three servings)
Dietary Supplement
Lead sponsor
University of Memphis
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Memphis, Tennessee
Conditions
Receptor Blockade
Interventions
Adenosine Triphosphate, Acetylcholine, Sodium Nitroprusside, Adenosine Diphosphate, Adenosine Monophosphate, Uridine Triphosphate, Adenosine, Vitamin B 6, Pyridoxal 5'-Phosphate
Drug
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 30 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Collins, Colorado
Completed Not applicable Interventional Accepts healthy volunteers

The Poweroff Sleep Study

NCT03364101
Conditions
Sleep
Interventions
Placebo Capsule, POWEROFF Capsule
Dietary Supplement
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Conditions
Colorectal Cancer, Chemotherapy-induced Peripheral Neuropathy
Interventions
Calmangafodipir (2 µmol/kg), Calmangafodipir (5 µmol/kg), Placebo
Drug
Lead sponsor
Egetis Therapeutics AB (publ)
Industry
Eligibility
18 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
11
States / cities
Fresno, California • Orange City, Florida • Wichita, Kansas + 8 more
Conditions
Epilepsy
Interventions
Mangafodipir, Gadolinium
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Interventions
Calmangafodipir, Placebo
Drug
Lead sponsor
Egetis Therapeutics AB (publ)
Industry
Eligibility
20 Years to 55 Years · Male only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Cypress, California
Conditions
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury, Myocardial Revascularization
Interventions
(MC-1) Pyridoxal-5'-phosphate
Drug
Lead sponsor
Medicure
Industry
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Durham, North Carolina
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study to Assess a Dietary Supplement on Sleep Health and Quality

NCT05368909
Conditions
Sleep Quality, Sleep Health
Interventions
Sleep Supplement, Placebo
Dietary Supplement
Lead sponsor
4Life Research, LLC
Industry
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Sandy City, Utah
Conditions
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury
Interventions
(MC-1) Pyridoxal 5'-phosphate
Drug
Lead sponsor
Medicure
Industry
Eligibility
18 Years and older
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Durham, North Carolina