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ClinicalTrials.gov public records Last synced Sep 5, 2026, 5:44 PM EDT

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Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: QUAD Clear all
Not yet recruiting Not applicable Interventional

Using a Smart Implantable Device to Compare Early Recovery in Two Different Knee Arthroplasty Approaches

NCT07348835
View directory record Official record
Conditions
Total Knee Anthroplasty
Interventions
Total Knee Arthroplasty Medial Parapatellar Approach, Total Knee Arthroplasty Subvastus Approach
Procedure
Lead sponsor
Total Joint Specialists
Network
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Sandy Springs, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 5, 2026, 5:44 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Two Time a Week vs. Five Time a Week Blood Flow Restriction Training Program for the Lower Extremity.

NCT05342909
View directory record Official record
Conditions
Blood Flow Restriction Training
Interventions
5x a week BFR training group, 2x a week BFR training group
Other
Lead sponsor
George Fox University
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Newberg, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 24, 2022 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Phase 4 Interventional

Tolvaptan/Ultrafiltration in the Treatment of Acute Heart Failure

NCT01863511
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
loop diuretic, tolvaptan, ultrafiltration
Drug · Procedure
Lead sponsor
The Christ Hospital
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 27, 2016 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Phase 2 Interventional Results available

New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C

NCT01888900
View directory record Official record
Conditions
Cirrhosis, Chronic Hepatitis C, Hepatitis C, Hepatitis C, Chronic
Interventions
DUAL, QUAD
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 6, 2017 · Synced Sep 5, 2026, 5:44 PM EDT
Recruiting Not applicable Interventional

PCS in Severe Treatment Resistant Depression

NCT04124341
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Prefrontal Cortical Stimulation (PCS)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
22 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2032
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Phase 2 Interventional Results available

Selinexor Treatment of Refractory Myeloma

NCT02336815
View directory record Official record
Conditions
Multiple Myeloma
Interventions
Selinexor, Dexamethasone
Drug
Lead sponsor
Karyopharm Therapeutics Inc
Industry
Eligibility
18 Years and older
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
36
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Duarte, California + 28 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Sep 5, 2026, 5:44 PM EDT
Active, not recruiting No phase listed Observational

Personalized Therapy Study - Attain Stability Quad Post-Approval Study

NCT04024943
View directory record Official record
Conditions
Heart Failure
Interventions
Quadripolar LV Lead
Device
Lead sponsor
Medtronic
Industry
Eligibility
Not listed
Enrollment
1,092 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2028
U.S. locations
72
States / cities
Anchorage, Alaska • Chandler, Arizona • Jonesboro, Arkansas + 62 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 5, 2026, 5:44 PM EDT
Not yet recruiting Not applicable Interventional

Dry Needling and Quad Strength After Anterior Cruciate Ligament Reconstruction

NCT07657195
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction Rehabilitation, Dry Needling, Strength
Interventions
Dry Needling
Procedure
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
10 Years to 20 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Kansas City, Kansas • Overland Park, Kansas • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 5, 2026, 5:44 PM EDT
Active, not recruiting Phase 1 Interventional

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

NCT05768880
View directory record Official record
Conditions
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, Recurrent CNS Tumor, Adult, Recurrent, CNS Tumor, Childhood, Refractory Primary Malignant Central Nervous System Neoplasm
Interventions
SC-CAR4BRAIN
Biological
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
1 Year to 26 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2043
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Rehabilitation Programs for Patellofemoral Pain Syndrome

NCT00445224
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Hip Progressive Resistive Exercise, Quad Progressive Resistive Exercises
Other
Lead sponsor
Timothy Uhl
Other
Eligibility
15 Years to 35 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Sep 5, 2026, 5:44 PM EDT
Active, not recruiting Not applicable Interventional

STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon

NCT03935750
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Reconstruction, Joint Instability
Interventions
Anterior cruciate ligament reconstruction (ACLR), Lateral extra-articular tenodesis (LET)
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 25 Years
Enrollment
1,272 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
14
States / cities
Redwood City, California • San Francisco, California • Orlando, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Soft Tissue Therapy and Exercise on Hamstring Tightness

NCT03651141
View directory record Official record
Conditions
Hamstring Tightness, Myofascial Pain, Musculoskeletal Pain
Interventions
Neurodynamic Sliding, Myofascial Decompression, Diathermy
Other
Lead sponsor
Oklahoma State University
Other
Eligibility
18 Years to 25 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Stillwater, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 5, 2026, 5:44 PM EDT
Recruiting Not applicable Interventional

The Effects of Dry Needling on Patients With Knee Pain

NCT02890485
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Interventions
Dry Needling, Sham Dry Needling, Physical Therapy
Device · Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 40 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2030
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Quad Resection (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)

NCT03462706
View directory record Official record
Conditions
Colon Cancer, Colon Polyp, Colon Adenoma
Interventions
Cold Snare, Hot Snare, Cold EMR, Hot EMR
Procedure
Lead sponsor
Indiana University
Other
Eligibility
40 Years and older
Enrollment
238 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Phase 3 Interventional Results available

Treatment of Acute HIV Infection With Quad Fixed-dose Combination (FDC) Tablet

NCT01694420
View directory record Official record
Conditions
HIV
Interventions
(FDC) ELV/COBI/FTC/TDF
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Phase 3 Pivotal Trial of NanoFlu™ in Older Adults

NCT04120194
View directory record Official record
Conditions
Influenza, Human
Interventions
NanoFlu, Fluzone Quadrivalent
Biological
Lead sponsor
Novavax
Industry
Eligibility
65 Years and older
Enrollment
2,654 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
19
States / cities
Hollywood, Florida • Savannah, Georgia • Stockbridge, Georgia + 16 more
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Not applicable Interventional Results available

Attain Stability™ Quad Clinical Study

NCT03099655
View directory record Official record
Conditions
Heart Failure
Interventions
Attain Stability Quad Left Ventricular Pacing Lead
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
471 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
35
States / cities
Phoenix, Arizona • East Palo Alto, California • Torrance, California + 30 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2020 · Synced Sep 5, 2026, 5:44 PM EDT
Recruiting Not applicable Interventional

Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs

NCT06560502
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Leg Ulcer, Ulcer Foot, Leg Ulcer
Interventions
Standard of Care-DFU, AmnioCore - DFU, Amnio Quad-Core - DFU, Standard of Care-VLU, Amnio Tri-Core - VLU, Amniocore Pro +
Other
Lead sponsor
Stability Biologics
Industry
Eligibility
21 Years and older
Enrollment
324 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Circleville, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 19, 2025 · Synced Sep 5, 2026, 5:44 PM EDT
Recruiting Not applicable Interventional

Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT

NCT05461326
View directory record Official record
Conditions
Orthopedic Disorder, Anterior Cruciate Ligament Injuries
Interventions
Quad tendon, BTB
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
14 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Phase 1 Interventional

Follistatin Gene Transfer to Patients With Becker Muscular Dystrophy and Sporadic Inclusion Body Myositis

NCT01519349
View directory record Official record
Conditions
Becker Muscular Dystrophy, Sporadic Inclusion Body Myositis
Interventions
rAAV1.CMV.huFollistatin344
Biological
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 1, 2023 · Synced Sep 5, 2026, 5:44 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Safety and Efficacy in Participants With Metastatic BRAF-mutant Melanoma Treated With Encorafenib With and Without Binimetinib in Combination With Nivolumab and Low-dose Ipilimuma

NCT04655157
View directory record Official record
Conditions
Melanoma
Interventions
encorafenib, nivolumab, ipilimumab, binimetinib
Drug
Lead sponsor
Jason J. Luke, MD
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Sep 5, 2026, 5:44 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

HIV Non-Occupational Post-Exposure Prophylaxis

NCT01855867
View directory record Official record
Conditions
Human Immunodeficiency Virus
Interventions
Single Dose Elivitegravir (150mg), Combicistat (150mg), Emtricitabine (200mg), Tenofovir DF (300mg)
Drug
Lead sponsor
Kenneth H. Mayer, MD
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 18, 2022 · Synced Sep 5, 2026, 5:44 PM EDT
Enrolling by invitation No phase listed Observational

Blood Flow Restriction Following ACLR w/Quad Autograft

NCT06636045
View directory record Official record
Conditions
Autografts, Blood Flow Restriction Therapy, Rehabilitation Outcome, Quadriceps Muscle Strength, Anterior Cruciate Ligament Reconstruction
Interventions
Not applicable- observational study
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
14 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Sep 5, 2026, 5:44 PM EDT
Active, not recruiting Phase 2 Interventional

"QUAD SHOT" Radiotherapy With Pembrolizumab in Patients With Recurrent Head & Neck Cancer

NCT04373642
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
Pebrolizumab + QUADSHOT Radiotherapy
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 5, 2026, 5:44 PM EDT