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Showing 1–24 of 34 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: R3 Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?

NCT07546409
View directory record Official record
Conditions
Prediabetes, Healthy (Controls)
Interventions
Ketone Monoester (KE), Placebo
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
60 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Phase 2 Interventional Results available

Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant

NCT00096161
View directory record Official record
Conditions
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Graft Versus Host Disease, Hodgkin Lymphoma, Myelodysplastic/Myeloproliferative Neoplasm, Non-Hodgkin Lymphoma, Plasma Cell Myeloma, Waldenstrom Macroglobulinemia
Interventions
Cyclosporine, Mycophenolate Mofetil, Pentostatin, Therapeutic Allogeneic Lymphocytes
Drug · Biological
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
Not listed
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2015
U.S. locations
4
States / cities
Salt Lake City, Utah • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Sep 5, 2026, 9:53 PM EDT
Terminated Phase 2 Interventional

A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain Metastases

NCT00872482
View directory record Official record
Conditions
Metastatic Non-Small Cell Lung Cancer
Interventions
nimotuzumab
Drug
Lead sponsor
YM BioSciences
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
3
States / cities
New Port Richey, Florida • Saint Louis Park, Minnesota • Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Jun 30, 2011 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Online Learning Module to Advance Research Related to People With Disabilities

NCT07220837
View directory record Official record
Conditions
Developmental Disability, Intellectual Disability, Disability
Interventions
eLearning module, Control
Other
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 5, 2026, 9:53 PM EDT
Recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Ketone Ester Intervention in Alcohol Use Disorder

NCT04616781
View directory record Official record
Conditions
Alcohol Drinking, Alcohol Use Disorder
Interventions
Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", Isocaloric dextrose placebo, Alcohol drinks
Dietary Supplement · Drug · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 5, 2026, 9:53 PM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

MeFAMP for Imaging System A Amino Acid Transport in Primary and Metastatic Brain Tumors

NCT05676489
View directory record Official record
Conditions
Healthy Volunteers, Recurrent Glioma, Brain Metastases From Extra-cranial Solid Tumors
Interventions
[F-18]MeFAMP PET
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Months to 89 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2029
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Phase 2 Interventional Results available

Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT01024010
View directory record Official record
Conditions
Chronic Lymphocytic Leukemia, Stage 0 Chronic Lymphocytic Leukemia, Stage I Chronic Lymphocytic Leukemia, Stage I Small Lymphocytic Lymphoma, Stage II Chronic Lymphocytic Leukemia, Stage II Small Lymphocytic Lymphoma, Stage III Chronic Lymphocytic Leukemia, Stage III Small Lymphocytic Lymphoma, Stage IV Chronic Lymphocytic Leukemia, Stage IV Small Lymphocytic Lymphoma
Interventions
Cyclophosphamide, Laboratory Biomarker Analysis, Ofatumumab, Pentostatin
Drug · Other · Biological
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
4
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Sep 5, 2026, 9:53 PM EDT
Completed No phase listed Observational Results available

R3 Delta Ceramic Acetabular System PAS U.S.

NCT03056534
View directory record Official record
Conditions
Degenerative Joint Disease
Interventions
R3 Biolox Delta Ceramic Acetabular System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
189 participants
Timeline
2018 – 2023
U.S. locations
8
States / cities
Tampa, Florida • Tucker, Georgia • Annapolis, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2025 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Study of Abemaciclib in Healthy Participants

NCT02672423
View directory record Official record
Conditions
Healthy
Interventions
Abemaciclib Capsules (Reference Formulation), Abemaciclib Tablet (Test Formulation)
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Daytona Beach, Florida • Evansville, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 3, 2019 · Synced Sep 5, 2026, 9:53 PM EDT
Enrolling by invitation Phase 2Phase 3 Interventional Accepts healthy volunteers

Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder

NCT05015881
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Alcohol Drinking
Interventions
Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", FDG
Dietary Supplement · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 5, 2026, 9:53 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

NCT07063732
View directory record Official record
Conditions
High Altitude Hypoxia, Exercise
Interventions
Ketone Monoester (KME), Placebo
Dietary Supplement
Lead sponsor
McMaster University
Other
Eligibility
18 Years to 35 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Bishop, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced Sep 5, 2026, 9:53 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation Exploring How Course Modality Influences the Effectiveness of the R3 Academy for Couples

NCT05580627
View directory record Official record
Conditions
Program Modality
Interventions
Livestream Modality (treatment), Live Modality (control)
Other
Lead sponsor
Healthy Relationships California
Other
Eligibility
18 Years and older
Enrollment
255 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Leucadia, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Sep 5, 2026, 9:53 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

R3® Acetabular System in Patients With Degenerative Hip Disease

NCT01407029
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
5
States / cities
Vero Beach, Florida • Chicago, Illinois • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 5, 2026, 9:53 PM EDT
Terminated Phase 1Phase 2 Interventional

A Study of Nimotuzumab in Combination With External Radiotherapy in Non-Small Cell Lung Cancer

NCT00369447
View directory record Official record
Conditions
Non-small-cell Lung Cancer
Interventions
External radiotherapy, nimotuzumab
Procedure · Biological
Lead sponsor
YM BioSciences
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
New Port Richey, Florida
Source: ClinicalTrials.gov public record
Updated Jun 30, 2011 · Synced Sep 5, 2026, 9:53 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluating How Course Modality Influences the Effectiveness of the R3 Academy for Dads

NCT05580900
View directory record Official record
Conditions
Program Modality
Interventions
Livestream Modality (treatment), Live Modality (control)
Other
Lead sponsor
Healthy Relationships California
Other
Eligibility
18 Years and older · Male only
Enrollment
510 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Leucadia, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study To Assess The Pharmacokinetics Of 2 Different Formulations Of PF-04991532

NCT01388829
View directory record Official record
Conditions
Healthy
Interventions
Treatment A, Treatment B
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 9, 2011 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Phase 1 Interventional Results available

Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy

NCT02879643
View directory record Official record
Conditions
ALL, Childhood, Lymphoblastic Leukemia, Acute, Childhood, Lymphoblastic Leukemia, Acute
Interventions
Marqibo
Drug
Lead sponsor
Therapeutic Advances in Childhood Leukemia Consortium
Other
Eligibility
1 Year to 21 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
28
States / cities
Los Angeles, California • Orange, California • San Francisco, California + 25 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Not applicable Interventional

Dry Needling and Manipulation vs. Mobilization, Exercise and Interferential Electrotherapy for Shoulder Impingement (Subacromial Pain Syndrome)

NCT03168477
View directory record Official record
Conditions
Subacromial Pain Syndrome
Interventions
dry needling, spinal manipulation, mobilization, exercise, modalities
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cockeysville, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Sep 5, 2026, 9:53 PM EDT
Terminated Phase 1 Interventional

Study to Evaluate the Safety, Tolerability, and Efficacy of SRP-9004 Administered by Systemic Infusion in Limb Girdle Muscular Dystrophy Type 2D/R3 Participants in the United States

NCT06747273
View directory record Official record
Conditions
Limb Girdle Muscular Dystrophy, Limb Girdle Muscular Dystrophy Type 2D/R3
Interventions
SRP-9004
Drug
Lead sponsor
Sarepta Therapeutics, Inc.
Industry
Eligibility
4 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Columbus, Ohio • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Sep 5, 2026, 9:53 PM EDT
Recruiting Not applicable Interventional

Safety and Effectiveness of the HIT Reverse HRS

NCT05357378
View directory record Official record
Conditions
Degenerative Joint Disease, Osteoarthritis, Hip, Avascular Necrosis of Hip, Traumatic Arthropathy-Hip
Interventions
Hip Innovation Technology Reverse Hip Replacement System, Already-marketed semi-constrained uncemented hip systems using a metal-on-XLPE or ceramic-on-XLPE bearing combination.
Device
Lead sponsor
Hip Innovation Technology
Industry
Eligibility
50 Years to 75 Years
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2035
U.S. locations
6
States / cities
Miami, Florida • Tampa, Florida • Baltimore, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Phase 2 Interventional

Ketones in Heart Failure With Reduced Ejection Fraction

NCT06195982
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
ketone ester, placebo
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 5, 2026, 9:53 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Oregon Supplement: Supporting Sustainable Positive Interactions in the Child Welfare System: The R3 Supervisor Strategy

NCT05475457
View directory record Official record
Conditions
Evidence-Based Practice
Interventions
R3
Behavioral
Lead sponsor
Oregon Social Learning Center
Other
Eligibility
18 Years and older
Enrollment
404 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Sep 5, 2026, 9:53 PM EDT
Recruiting Phase 4 Interventional

Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy

NCT03249337
View directory record Official record
Conditions
Fuchs' Endothelial Dystrophy
Interventions
Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
Drug
Lead sponsor
Marian Macsai, MD
Other
Eligibility
18 Years to 91 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Glenview, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 10, 2021 · Synced Sep 5, 2026, 9:53 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Protonics Knee Brace Versus Hamstring Resisted Exercise (HRE) on Individuals With Patellofemoral Pain Syndrome

NCT03042559
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Protonics Knee brace, Sports Cords
Device
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 45 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Sep 5, 2026, 9:53 PM EDT