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Conditions: Multimorbidity
Interventions: SLIMM - Sit less, interact, move more, PB125; Behavioral · Dietary Supplement
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 60 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Peripheral Nerve Injury, Peripheral Nerve Discontinuity, Mixed Peripheral Nerve Injury, Motor Peripheral Nerve Injury, Upper Extremity Nerve Injury
Interventions: Avance Nerve Graft, Sural nerve autograft; Biological · Procedure
Lead sponsor: Axogen Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Triple Negative Breast Cancer (TNBC)
Interventions: RESTORE, Enhanced Usual Care; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Post Traumatic Stress Disorder
Interventions: webSTAIR, CHW coaching; Behavioral
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Epilepsy, Temporal Lobe
Interventions: Central Thalamic Stimulation, Hippocampal Stimulation; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 3
States / cities: New Haven, Connecticut • Rochester, Minnesota • Lebanon, New Hampshire

Conditions: Aging
Interventions: Hydration-Dehydration-Rehydration Protocol (HDR); Behavioral
Lead sponsor: Texas Tech University; Other
Eligibility: 45 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Mastectomy, Breast, Chronic Pain
Interventions: Bionic Breast implant; Device
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older · Female only
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Male Breast Cancer, Recurrent Breast Cancer, Stage IV Breast Cancer
Interventions: vorinostat, laboratory biomarker analysis, biopsy, F-18 16 alpha-fluoroestradiol, positron emission tomography, anastrozole, letrozole, exemestane, gene expression analysis; Drug · Other · Procedure + 2 more
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Microbiota, Eczema, Microbiome, Gut Microbiome
Interventions: Tailored Recommendations, Consult Call, Email Series; Dietary Supplement · Behavioral
Lead sponsor: Seeding Inc; Industry
Eligibility: 0 Months to 3 Months
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Fredericksburg, Texas

Conditions: Peripheral Vascular Disease
Interventions: Cryoplasty (PolarCath peripheral balloon catheter), Laser Angioplasty (Spectranetics), SilverHawk Atherectomy, Viabahn Endograft, Angioplasty/Stent (Guidant "Absolute" stent); Procedure · Device
Lead sponsor: Arizona Heart Institute; Other
Eligibility: 18 Years and older
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Obesity
Interventions: RS2 (RESTORe Suturing System); Device
Lead sponsor: C. R. Bard; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Boston, Massachusetts • Cleveland, Ohio

Conditions: Traumatic Brain Injury
Interventions: rTMS, Placebo rTMS; Device
Lead sponsor: Edward Hines Jr. VA Hospital; Federal
Eligibility: 18 Years and older
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 2
States / cities: Chicago, Illinois • Hines, Illinois

Conditions: Quadriplegia, Spinal Cord Diseases, Spinal Cord Injuries
Interventions: Nerve Transfer Surgery; Procedure
Lead sponsor: Ottawa Hospital Research Institute; Other
Eligibility: 18 Years to 60 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Long-Term Memory Decline, Mild Cognitive Impairment
Interventions: LabyrinthVR, Placebo Games, Coherence, Tablet; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 62 Years to 85 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Edentulism, Alveolar Bone Atrophy, Sinus Pneumatization
Interventions: Sinus grafting using allogenic bone; Procedure
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 85 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Erythrocyte Transfusion
Interventions: Transfusion of rejuvenated and washed autolgous RBCs, Transfusion of washed autolgous RBCs; Biological
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Lower Back Pain
Interventions: RESTORE Intervention; Other
Lead sponsor: Defense and Veterans Center for Integrative Pain Management; Other
Eligibility: 18 Years to 68 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Parkinson's Disease, Sleep Fragmentation
Interventions: Deep Brain Stimulation; Device
Lead sponsor: University of Nebraska; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Omaha, Nebraska • Philadelphia, Pennsylvania

Conditions: Enteral Nutrition
Interventions: TubeClear® intervention; Device
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: Up to 17 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Healthy
Interventions: Stress First Aid; Behavioral
Lead sponsor: RAND; Other
Eligibility: Not listed
Enrollment: 7,444 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: New York, New York • Irving, Texas

Conditions: Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions: Whole Body Vibration; Behavioral
Lead sponsor: OHSU Knight Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Bacterial Vaginosis, Vaginal Flora Imbalance
Interventions: Flourish Vaginal Care System; Combination Product
Lead sponsor: Vaginal Biome Science; Other
Eligibility: 18 Years to 52 Years · Female only
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Concord, New Hampshire

Conditions: Coronary Artery Disease, Percutaneous Coronary Intervention
Interventions: Percutaneous coronary intervention; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 30,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Autism Spectrum Disorder, Autism, Autism Spectral Disorder
Interventions: Autologous MSC isolation, concentration, and cryopreservation of adult mesenchymal stem cells, Fecal Biomicrome Transplantation (FMT), Ketogenic RESET Diet Protocol, Trial combines use of cSVF and MSCs (cryopres) with diet modification and FMT (fecal material Transplant in adult ASD patients, FMT (Fecal Material Tranplantation), Use autologous cSVF + MSCs (cryo) for management of autoimmune component, anti-inflammatory and immune modulation; Procedure · Dietary Supplement · Behavioral + 1 more
Lead sponsor: Black Tie Medical, Inc.; Industry
Eligibility: 10 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 2
States / cities: Hamilton, Montana

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Physical Activity Modifies Exercise Responsiveness

A Prospective, Randomized, Assessor-Blinded, Multicenter Study Comparing Avance Nerve Graft and Autograft for Functional Recovery Following Mixed and Motor Peripheral Nerve Reconstruction

A Nurse-Led, Coping and Supportive Intervention for Patients With Triple-Negative Breast Cancer

Web-administered STAIR for Patients on Behavioral Health Waitlists

Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy

Dehydration, Rehydration, and Impact on Physiology

A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Aromatase Inhibitor Therapy

Infant Restore: Efficacy of Microbiome Analysis and Education

Prime Time for Superficial Femoral Artery (SFA) - The SFA Study

Transoral Gastric Volume Reduction as an Intervention for Weight Management

rTMS: A Treatment to Restore Function After Severe TBI

Nerve Transfers to Restore Hand Function in Spinal Cord Injury

Wayfinding Intervention in High-Fidelity Long-Term Memory

The Influence of Dimensional Anatomic Variables on the Outcomes of Maxillary Sinus Grafting Procedures

Rejuvenated RBC and VO2 Max in Healthy Subjects

Restorative Exercise for Strength Training and Operational Resilience (RESTORE) for Chronic or Recurrent Low Back Pain

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)

TubeClear® Evaluation in Pediatric Patients (Phase I)

Mental and Physical Well-Being of Frontline Health Care Workers During Coronavirus Disease 2019 (COVID-19)

Whole Body Vibration for the Improvement of Health and Functioning in Participants With Chemotherapy-Induced Peripheral Neuropathy

Clinical Trial to Survey Results of Flourish Vaginal Care System for Recurrent Bacterial Vaginosis

The xDAPT External Validation Study

Autism Spectrum Disorder (ASD) Neurodevelopmental Disorder With Issues Social Behavior, Communication Issues, GI Dysfunction. Study is Multimodal Interventions Targeting These Pathways With cSVF, Stored MSCs, FMT and Diet Modification. Role of Autoimmunity, Gut-brain Issues, & Issues Examined.