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ClinicalTrials.gov public records Last synced Oct 3, 2026, 10:59 AM EDT

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Showing 25–48 of 64 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Radiation Therapy to partial breast Clear all
Not yet recruiting Phase 1Phase 2 Interventional

aPBI Re-irradiation

NCT07612254
View directory record Official record
Conditions
Breast Cancer Recurrent
Interventions
Reirradiation
Radiation
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2033
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Not applicable Interventional

Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer

NCT00103181
View directory record Official record
Conditions
Breast Cancer
Interventions
3-dimensional conformal accelerated partial breast irradiation, brachytherapy, whole breast irradiation, MammoSite or other single-entry intracavitary device
Radiation
Lead sponsor
NSABP Foundation Inc
Network
Eligibility
18 Years and older · Female only
Enrollment
4,216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2018
U.S. locations
374
States / cities
Birmingham, Alabama • Peoria, Arizona • Phoenix, Arizona + 295 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2022 · Synced Oct 3, 2026, 10:59 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

CyberKnife Stereotactic Accelerated Partial Breast Irradiation (SAPBI)

NCT02365714
View directory record Official record
Conditions
Breast Cancer, DCIS, Invasive Ductal Carcinoma
Interventions
CK Stereotactic Accelerated Partial Breast Irradiation
Radiation
Lead sponsor
Georgetown University
Other
Eligibility
50 Years to 99 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 13, 2018 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Not applicable Interventional Results available

4D Image-Guided Partial Breast Radiation in Stage 0 and l Breast Cancer

NCT01646346
View directory record Official record
Conditions
Breast Cancer
Interventions
4D Conformal Image-Guided Partial Breast RT
Radiation
Lead sponsor
Yale University
Other
Eligibility
50 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 23, 2018 · Synced Oct 3, 2026, 10:59 AM EDT
Withdrawn Phase 2 Interventional

Proton Accelerated Partial Breast Irradiation

NCT03940248
View directory record Official record
Conditions
Breast Cancer
Interventions
Proton Accelerated Partial Breast Irradiation
Radiation
Lead sponsor
University of Cincinnati
Other
Eligibility
50 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Oct 3, 2026, 10:59 AM EDT
Withdrawn Not applicable Interventional

A Pilot Study of CyberKnife Radiosurgery Delivered to the Partial Breast

NCT00529334
View directory record Official record
Conditions
Breast Cancer
Interventions
CyberKnife Partial Breast Irradiation
Radiation
Lead sponsor
Georgetown University
Other
Eligibility
45 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2013 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Phase 2 Interventional

Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors

NCT04343573
View directory record Official record
Conditions
Leptomeningeal Metastases
Interventions
Involved-field Photon Radiation Therapy, Proton Craniospinal Irradiation (CSI), Neurocognitive Assessment, MDASI-BT and MDASI-SP
Radiation · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
Up to 99 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Not applicable Interventional Results available

Proton Therapy for Early Stage Breast Cancer

NCT00614172
View directory record Official record
Conditions
Early-Stage Breast Cancer
Interventions
Proton radiation therapy
Radiation
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2020
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Early Phase 1 Interventional

Partial Breast Radiation Therapy in Treating Women Undergoing Breast-Conserving Therapy for Early Stage Breast Cancer

NCT00527293
View directory record Official record
Conditions
Breast Cancer
Interventions
adjuvant therapy, 3-dimensional conformal radiation therapy, brachytherapy
Procedure · Radiation
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
4
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 25, 2015 · Synced Oct 3, 2026, 10:59 AM EDT
Active, not recruiting Phase 1 Interventional

A Phase I Dose Escalation Study of Single Fraction Pre-operative Partial Breast (S-PBI) for Early Stage Breast Cancer

NCT04040569
View directory record Official record
Conditions
Breast Cancer
Interventions
Radiomics on MRI
Radiation
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Not applicable Interventional Results available

Multi-Beam Intensity-Modulated Radiation Therapy for Node-Positive Breast Cancer

NCT01127373
View directory record Official record
Conditions
Breast Cancer
Interventions
Multi-Beam Intensity-Modulated Radiation Therapy, BreastQ questionnaire-
Radiation · Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Commack, New York + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Phase 1 Interventional Results available

A Study of Rucaparib Administered With Radiation in Patients With Triple Negative Breast Cancer With an Incomplete Response Following Chemotherapy

NCT03542175
View directory record Official record
Conditions
Breast Cancer
Interventions
Rucaparib, Radiotherapy
Drug · Radiation
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
8
States / cities
Norwalk, Connecticut • Basking Ridge, New Jersey • Middletown, New Jersey + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Oct 3, 2026, 10:59 AM EDT
Recruiting Not applicable Interventional

RAD 1802: Pilot Trial of Five Fraction Stereotactic Body Radiotherapy for Early Stage Breast Cancer Patients Eligible for Post-Operative Accelerated Partial Breast Irradiation (APBI)

NCT03643861
View directory record Official record
Conditions
Breast Cancer
Interventions
5 Fraction Stereotactic Body Radiation Therapy
Radiation
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 3, 2026, 10:59 AM EDT
Active, not recruiting Phase 2 Interventional Results available

Intraoperative Electron Beam Radiotherapy Boost in Treating Patients With Stage I-II Breast Cancer Undergoing Surgery With Reconstruction

NCT02927912
View directory record Official record
Conditions
Stage IA Breast Cancer, Stage IB Breast Cancer, Stage IIA Breast Cancer, Stage IIB Breast Cancer
Interventions
Electron Beam Therapy, Lumpectomy, Quality-of-Life Assessment, Questionnaire Administration, Radiation Therapy, Reconstructive Surgery
Radiation · Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Cleveland, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 3, 2026, 10:59 AM EDT
Recruiting Phase 2 Interventional

Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer

NCT04084730
View directory record Official record
Conditions
Invasive Ductal Breast Carcinoma, Invasive Ductal Carcinoma, Breast, DCIS, DCIS Grade 1, DCIS Grade 2, Breast Cancer
Interventions
Accelerated Partial Breast Irradiation
Radiation
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
45 Years and older · Female only
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
9
States / cities
Norwalk, Connecticut • Miami, Florida • Basking Ridge, New Jersey + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 3, 2026, 10:59 AM EDT
Not listed Phase 1Phase 2 Interventional

Partial Breast Radiation to the Lumpectomy Cavity With IMRT in Elderly Women

NCT00337064
View directory record Official record
Conditions
Stage I Breast Cancer
Interventions
Radiation Therapy
Procedure
Lead sponsor
University of Vermont
Other
Eligibility
65 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 15, 2006 · Synced Oct 3, 2026, 10:59 AM EDT
Withdrawn Not applicable Interventional

Preoperative Accelerated Partial Breast Irradiation for Triple Negative Breast Cancer Using Proton Beam Scanning

NCT03340402
View directory record Official record
Conditions
Breast Cancer
Interventions
Accelerated Partial Breast Irradiation, AlignRT
Radiation · Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 14, 2019 · Synced Oct 3, 2026, 10:59 AM EDT
Active, not recruiting Not applicable Interventional Results available

MRI-Based Preoperative Accelerated Partial Breast Irradiation

NCT02728076
View directory record Official record
Conditions
Breast Cancer
Interventions
Phase II - Preoperative Radiation followed by Lumpectomy.
Radiation
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
40 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Phase 4 Interventional

Use of the Contura™ Catheter in Intermediate-Risk, Pathological Stage 0, I, or II (Up to 3.0 cm) Breast Cancer Patients

NCT00882089
View directory record Official record
Conditions
Breast Cancer
Interventions
Contura catheter
Device
Lead sponsor
Cancer Center of Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Not applicable Interventional Results available

Partial Breast Irradiation Using Non Invasive Approach for Early Stage Breast Cancer

NCT01463007
View directory record Official record
Conditions
Breast Cancer
Interventions
Accelerated partial breast irradiation, Extended Follow up
Radiation · Other
Lead sponsor
Jaroslaw Hepel
Other
Eligibility
50 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2021
U.S. locations
4
States / cities
Lakeland, Florida • Providence, Rhode Island • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 3, 2026, 10:59 AM EDT
Terminated Not applicable Interventional Results available

Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer

NCT03137693
View directory record Official record
Conditions
Breast Cancer, Breast Cancer Female, Breast Adenocarcinoma
Interventions
Standard of Care Schedule Variation: SABR, Breast-conserving Surgery
Other · Procedure
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
50 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Oct 3, 2026, 10:59 AM EDT
Completed Not applicable Interventional

Selective Image Guided Resection of Axillary Lymph Nodes

NCT01880645
View directory record Official record
Conditions
Breast Cancer
Interventions
Fine Needle Aspiration (FNA), Ultrasound, Breast Surgery + Lymph Node Removal
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2015 · Synced Oct 3, 2026, 10:59 AM EDT
Not listed No phase listed Observational

A Multi-Institutional Registry for CyberKnife Stereotactic Accelerated Partial Breast Irradiation (CK-SAPBI)

NCT02457117
View directory record Official record
Conditions
Breast Cancer
Interventions
CyberKnife Stereotactic Accelerated Partial Breast Irradiation (CK-SAPBI)
Radiation
Lead sponsor
Georgetown University
Other
Eligibility
50 Years to 99 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Oct 3, 2026, 10:59 AM EDT
Not listed Not applicable Interventional

Intraoperative Boost Radiotherapy With Electrons (IOERT) Followed By Hypofractionated Whole-Breast Irradiation (WBRT)

NCT01295723
View directory record Official record
Conditions
Invasive Lobular and Ductal Carcinoma
Interventions
Hypofractionated Whole Breast Radiation Therapy, Intraoperative Electron Radiation Therapy
Radiation
Lead sponsor
St. Joseph Hospital of Orange
Other
Eligibility
40 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2022
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 3, 2026, 10:59 AM EDT