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Conditions: Depression, End Stage Renal Disease
Interventions: Engagement Interview, Cognitive Behavioral Therapy, Antidepressant Drug Therapy; Behavioral · Drug
Lead sponsor: University of Washington; Other
Eligibility: 21 Years and older
Enrollment: 184 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 3
States / cities: Albuquerque, New Mexico • Dallas, Texas • Seattle, Washington

Conditions: Desaturation, Bradycardia, Tachycardia, Hypertension, Hypotension
Interventions: Rapid Response Team; Other
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Sepsis, Hypotension, Septic Shock
Interventions: NICOM; Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 251 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Ebola Virus Disease, Marburg Virus Disease
Interventions: cAd3-Marburg, cAd3-EBO-S; Biological
Lead sponsor: Albert B. Sabin Vaccine Institute; Other
Eligibility: 18 Years to 50 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Off-shift Robotic Telerounding
Interventions: Remote physician rounding; Behavioral
Lead sponsor: Lahey Clinic; Other
Eligibility: 18 Years to 75 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Burlington, Massachusetts

Conditions: Long COVID, Insulin Resistance, Insulin Sensitivity
Interventions: Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) Test; Procedure · Diagnostic Test
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: Palo Alto, California

Conditions: Opioid Use Disorder
Interventions: ConCERN intervention, Treatment as Usual; Behavioral · Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 700 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Detroit, Michigan

Conditions: Diabetes Mellitus, Type 2
Interventions: Self-management support education, Connection to Health Interactive Behavior Change Technology, Connection to Health plus Coaching (CTH+C); Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 21 Years to 89 Years
Enrollment: 901 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: HIV Infections
Interventions: Patient-centered injection site, Patient-centered adherence support, Provider education, Improved clinic communication strategies; Other · Behavioral
Lead sponsor: Public Health Foundation Enterprises, Inc.; Other
Eligibility: 18 Years and older · Male only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Cardiovascular Diseases, Respiratory Diseases, Neurologic Diseases
Interventions: Not listed
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Hypertension
Interventions: Self-Guided M.A.P. BP Improvement Program, Full Support M.A.P. BP Improvement Program; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 85 Years
Enrollment: 1,238,835 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 24
States / cities: Crescent City, California • Eureka, California • Los Angeles, California + 15 more

Conditions: Wounds and Injuries, Trauma
Interventions: Leadership training; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 79 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Heart Arrest
Interventions: Preemptive Rapid Response Team intervention; Other
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Long COVID, Brain Fog, Cognitive Impairment, Cognitive Dysfunction, Post-Acute COVID-19 Syndrome
Interventions: Processing Speed Training, In-lab Instrumental Activities of Daily Living Training, In-lab Brain Health Training, Transfer Package, Follow Up Phone Calls, Vocational Rehabilitation, Peer Mentoring, Reaction Time Training, Trans-auricular Vagus Nerve Stimulation: High Intensity, Trans-auricular Vagus Nerve Stimulation: Low Intensity; Behavioral · Procedure
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Sepsis
Interventions: Not listed
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 134 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Manhasset, New York

Conditions: Sepsis, Patient Deterioration
Interventions: SEPSys, RESCUE; Device
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Enrollment: 150,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 8
States / cities: Baltimore, Maryland • Bel Air, Maryland • Easton, Maryland + 4 more

Conditions: Menopause, Depression, Heart Disease in Women, Stress
Interventions: Trier Social Stress Test; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 44 Years to 55 Years · Female only
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Nonsmall Cell Lung Cancer Stage III, Unresectable Non-Small Cell Lung Carcinoma, Nonsmall Cell Lung Cancer, Stage II
Interventions: Durvalumab, the EORTC Core Quality of Life Questionnaire (EORTC QLQ-C30), COPD Assessment Test (CAT), Modified Medical Research Council (mMRC) dyspnea scale; Drug · Other · Diagnostic Test
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: Charlotte, North Carolina • Winston-Salem, North Carolina

Conditions: Perinatal Mental Health
Interventions: Lōvu platform, Standard Care Arm; Behavioral
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2032
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Sepsis, Deterioration, Clinical, Critical Illness, Early Warning Score
Interventions: Algorithm-triggered sepsis alert with structured critical care team activation; Other
Lead sponsor: Patricks Lyons; Other
Eligibility: 18 Years and older
Enrollment: 3,700 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Acute Pain, Burns, Adverse Drug Event, Respiratory Depression, Nausea and Vomiting, Postoperative
Interventions: Oliceridine, Historical opioid use; Drug
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Atrial Fibrillation
Interventions: Beta-blocker strategy, Calcium channel blocker strategy, Physician preference strategy; Drug
Lead sponsor: Boston University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: TBI
Interventions: Sildenafil citrate, Functional Near Infared Spectroscopy, Hypercapnia Challenge; Drug · Device · Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Outbreak Investigation
Interventions: Crowdsourced campaign package, Rapid Response Teams, Registry enrollment; Behavioral · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

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A Trial of Sertraline vs. CBT for End-stage Renal Disease Patients With Depression {ASCEND}

NTX Wireless Patient Monitoring System

Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock

Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults

The Role of Off-shift Robotic Telerounding Between Physicians and Nurses in the Surgical Intensive Care Unit

Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

The ConCERN Intervention for Loved Ones of Those With Opioid Use Disorder

Comparing Strategies for Translating Self-management Support Into Primary Care

The Cheeky Study: A Novel Delivery System for CAB-RPV LA

Need for the Assessment and Consultation Team (ACT) Following Anesthetic Care

Improving BP Control in Diverse Populations Using BP MAP

Study of Team Leadership Training Effect on Patient Care

Patient Acuity Rating: a Tool to Prevent In-Hospital Cardiac Arrest

Long COVID Brain Fog: Cognitive Rehabilitation Trial

Point of Care Ultrasound to Predict Intensive Care Unit Admission of Patients Presenting With Sepsis to the Emergency Department

UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial

Depression, Aging, Stress and Heart Health Study

Quick Start Durvalumab Following Chemoradiation for Stage III Nonsmall Cell Lung Cancer

Transforming Maternal Mental Health Care

Hospital-Onset Sepsis Systematic Detection and Structured Interventions

Oliceridine in Patients With Acute Burn Injuries

Assessment of Intravenous Rate Control Response in Atrial Fibrillation Trial (AIRCRAFT)

Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury

Leveraging Social Innovation and Community-Engagement to Reduce Disparities in Outbreak Control Outcomes