Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 5, 2026, 11:11 PM EDT

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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Conjunctival Staining
Interventions
Complete Easy Rub, ReNu MultiPlus, Clear Care, Contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Fort Worth, Texas
Conditions
Contact Lens Wear
Interventions
OPTI-FREE RepleniSH, ReNu MultiPlus MPS
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Conditions
Contact Lens Wear
Interventions
Custom Samfilcon B Contact Lenses, Alden Optical HP Sphere Contact Lens, ReNu MultiPlus Lubricating and Rewetting Drops, Biotrue Multi-Purpose Solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
7
States / cities
San Francisco, California • Denver, Colorado • Sarasota, Florida + 4 more
Conditions
Myopia
Interventions
O2Optix contact lens, Proclear contact lens, ReNu MultiPlus Multi-Purpose Solution, Clear Care Cleaning and Disinfecting Solution
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
473 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
25
States / cities
North Little Rock, Arkansas • Campbell, California • Cupertino, California + 22 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

Objective Testing of Tear Film Stability

NCT00789529
Conditions
Contact Lens Solutions
Interventions
Opti-Free® RepleniSH® MPDS, ReNu MultiPlus®
Device
Lead sponsor
Manhattan Vision Associates
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
New York, New York
Conditions
Contact Lens Wear
Interventions
Vistakon Investigational Multi-Purpose Solution II, ReNu MultiPlus Multi-Purpose Solution
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
14
States / cities
Mission Viejo, California • Orlando, Florida • Tallahassee, Florida + 11 more
Conditions
Contact Lens Solution Toxicity
Interventions
PureVision lenses soaked in ReNu Multiplus, PureVision lenses soaked in OptiFree RePlenish
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Fullerton, California
Conditions
Contact Lens Care
Interventions
FID 107027 Multi-Purpose Disinfecting Solution, ReNu MultiPlus Multi-Purpose Solution No Rub Formula
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
252 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004
U.S. locations
1
States / cities
Elkin, North Carolina
Conditions
Contact Lens Disinfecting Solutions
Interventions
ProClear Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in Optifree RepleniSH Multipurpose Solution, ProClear Lens Material soaked in Optifree RepleniSH Multipurpose Solution
Drug
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fullerton, California
Conditions
Ocular Hypertension
Interventions
Latanoprostene Bunod, Placebo
Drug
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Completed Not applicable Interventional Accepts healthy volunteers Results available

Corneal Staining and Physiological Compromise After Eight Hours of Soft Contact Lens Wear

NCT01015768
Conditions
Contact Lens-induced Corneal Fluorescein Staining
Interventions
ReNu Multiplus multipurpose disinfecting solution, Control
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fullerton, California
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Contact Lens Wear on Immune Cell Density and Morphology of the Ocular Surface

NCT01250925
Conditions
Myopia, Refractive Error
Interventions
ReNu MultiPlus® MultiPurpose Solution, OPTI-FREE® RepleniSH®, Clear Care®
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Iowa City, Iowa • Boston, Massachusetts
Conditions
Corneal Staining
Interventions
Opti-Free RepleniSH, ReNu MultiPlus, Balafilcon A, Unisol 4
Device · Other
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Fort Worth, Texas
Conditions
Myopia, Astigmatism, Refractive Error
Interventions
Lotrafilcon B contact lenses, Senofilcon A contact lenses, OPTI-FREE® PUREMOIST® MPDS, BIOTRUE®, Balafilcon A contact lenses, ReNu® Multiplus®
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Fort Worth, Texas
Conditions
Contact Lens Solution
Interventions
Opti-Free contact lens solution, ReNu Multiplus contact lens solution, Clear Care contact lens solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Virginia Beach, Virginia
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Daily Wear Corneal Infiltrative Event Study

NCT00937105
Conditions
Myopia, Hyperopia, Corneal Infiltrative Events
Interventions
lotrafilcon A contact lenses, Renu Multiplus, Clear Care
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
15 Years and older
Enrollment
218 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Contact Lens Related Dry Eye
Interventions
Opti-Free RepleniSH, ReNu MultiPlus, Contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Completed Not applicable Interventional Results available

Investigational Multi-purpose Contact Lens Care Solution.

NCT01055613
Conditions
Contact Lens Wear
Interventions
Vistakon Investigational Multi-Purpose Solution I, ReNu MultiPlus Multi-Purpose Solution
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
15
States / cities
Fresno, California • Pismo Beach, California • Louisville, Colorado + 12 more
Conditions
Contact Lens Wear
Interventions
ASP-57, ReNu® Multiplus
Device
Lead sponsor
Asepticys LLC
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
14
States / cities
Irvine, California • San Diego, California • Longwood, Florida + 11 more
Conditions
Contact Lens Moisture
Interventions
FID 114675A Multi-Purpose Disinfecting Solution (MPDS), ReNu Fresh Lens Comfort Multi-Purpose Solution (MPS), Silicone Hydrogel Contact Lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Conditions
Myopia
Interventions
Multi-Purpose Disinfecting Solution (OPTI-FREE RepleniSH), Contact Lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 65 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Fort Worth, Texas
Conditions
Comfort
Interventions
Bausch & Lomb ReNu MultiPlus Multi-Purpose Solution Packaged in the Currently Marketed Resin Bottle., Bausch & Lomb ReNu MultiPlus Multi-Purpose Solution Packaged in a Clear Resin Bottle.
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Rochester, New York