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ClinicalTrials.gov public records Last synced Oct 27, 2026, 3:03 PM EDT

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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Reference Toothpaste Clear all
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation

NCT07255040
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Test Dentifrice, Parodontax Complete Protection, Colgate Cavity Protection
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children

NCT06300073
View directory record Official record
Conditions
Dental Plaque
Interventions
Experimental: U-shaped Power Toothbrush, Placebo Comparator: Soft Manual Toothbrush
Device
Lead sponsor
Lander Enterprises, LLC
Industry
Eligibility
5 Years to 8 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks

NCT05459558
View directory record Official record
Conditions
Oral Hygiene
Interventions
Experimental Dentifrice 1, Experimental Dentifrice 2, Reference Dentifrice
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Apr 12, 2024 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome

NCT06048809
View directory record Official record
Conditions
Oral Health
Interventions
Stannous Fluoride Toothpaste (Sensodyne Repair and Protect), Regular Fluoride Toothpaste (Colgate Cavity Protection)
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Study to Evaluate the Anti-sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers

NCT06359028
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Stannous fluoride toothpaste, Crest cavity protection toothpaste
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Twelve Week Study of Supervised Mouth Rinse and Flossing

NCT04696536
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, American Dental Association (ADA) Referenced Toothbrush, 5% Hydroalcohol Mouth Rinse, REACH Dental Floss, Alcohol-containing Essential Oil (AEO) Mouth Rinse (Listerine Cool Mint, marketed)
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion

NCT01128972
View directory record Official record
Conditions
Tooth Erosion
Interventions
Sodium fluoride, Sodium monoflurophosphate, Sterile water
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 1, 2015 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque

NCT04921371
View directory record Official record
Conditions
Gingivitis, Plaque
Interventions
Colgate® Cavity Protection Toothpaste, Listerine® Cool Mint®, Concept Curve Winter Series Toothbrush, 5% Hydroalcohol Mouthrinse, Mouthrinse Prototype 1, Mouthrinse Prototype 2
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
157 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes

NCT07297732
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Test Toothpaste 1, Test Toothpaste 2, Reference Toothpaste
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Enamel Remineralization Potential of Dentifrices in Situ

NCT01128946
View directory record Official record
Conditions
Dental Caries
Interventions
NaF, SnF, NaMFP
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 1, 2015 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study of Virtually Supervised Mouth Rinses and Flossing

NCT05600231
View directory record Official record
Conditions
Healthy
Interventions
LISTERINE COOL MINT Antiseptic Mouthwash, LISTERINE COOL MINT ZERO Alcohol Mouthwash, Reach Unflavored Waxed Dental Floss, Colgate Cavity Protection Toothpaste
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 18, 2023 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Investigate the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health

NCT07704905
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Test Dentifrice, Reference Dentifrice (Colgate Cavity Protection Dentifrice)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Three Toothpastes Using an in Situ Caries Model

NCT02751320
View directory record Official record
Conditions
Dental Caries
Interventions
0.425 % w/w phytate,1150ppm F, 0.85 % w/w phytate,1150ppm F, 0.85 % w/w phytate,0.3%ZnCl2 0.5% sodium citrate, 1150ppm F, 0 ppm F, 1150ppm F, 0.3%ZnCl2, 0.5% sodium citrate, 1150ppm F
Drug · Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice

NCT07215767
View directory record Official record
Conditions
Dentin Hypersensitivity
Interventions
Stannous fluoride and Potassium nitrate Dentifrice, Stannous fluoride Dentifrice, Potassium nitrate Dentifrice, Vehicle Dentifrice
Drug
Lead sponsor
HALEON
Industry
Eligibility
12 Years to 65 Years
Enrollment
688 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
3
States / cities
Melbourne, Florida • Fort Wayne, Indiana • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluation of the Fluoride Dose Response Using In Situ Caries Model

NCT04763044
View directory record Official record
Conditions
Caries
Interventions
0 ppm F, 250 ppm F as MFP, 1100 ppm as MFP, 2800 ppm F as MFP, 1100 ppm SnF2
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching

NCT06150573
View directory record Official record
Conditions
Dentin Sensitivity, Oral Hygiene
Interventions
Test Dentifrice, Reference Dentifrice (Aquafresh Cavity Protection)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 24, 2025 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers

NCT06354270
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Stannous fluoride toothpaste, Regular fluoride toothpaste (Crest Cavity Protection)
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In Situ Caries Efficacy of Fluoride Toothpastes

NCT00708097
View directory record Official record
Conditions
Caries
Interventions
NaF, Placebo, NaMFP
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 78 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 1, 2015 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intra Oral Application (IOA) Testing Study of a Stannous Toothpaste

NCT07419672
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Treatment Slurry (Fluoride-Free), Active Comparator Fluoride Treatment (0.454% SnF), Test Fluoride Treatment (0.454% SnF) (Investigational Toothpaste)
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Results available

A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis

NCT05524948
View directory record Official record
Conditions
Halitosis
Interventions
Experimental Dentifrice, Reference Dentifrice
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel

NCT06242444
View directory record Official record
Conditions
Tooth Erosion
Interventions
Experimental Dentifrice, Placebo Control Dentifrice, Reference Dentifrice
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms

NCT02207400
View directory record Official record
Conditions
Oral Hygiene
Interventions
Sodium bicarbonate and sodium fluoride, Sodium fluoride
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
246 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of U-Shaped Sonic Toothbrush on Plaque and Gingivitis

NCT06126250
View directory record Official record
Conditions
Plaque Induced Gingivitis
Interventions
Power sonic toothbrush, Manual toothbrush
Device
Lead sponsor
Lander Enterprises, LLC
Industry
Eligibility
5 Years to 65 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 13, 2023 · Synced Oct 27, 2026, 3:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate the Efficacy of a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation

NCT06933368
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Crest Cavity Protection Toothpaste, Experimental Mouthwash
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 26, 2026 · Synced Oct 27, 2026, 3:03 PM EDT