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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Refined grains Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

MyGI Diet for Colorectal Cancer Prevention

NCT05396846
View directory record Official record
Conditions
Colorectal Neoplasms
Interventions
Eating Plan 1, Eating Plan 2, Eating Plan 3
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
19 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals

NCT02602496
View directory record Official record
Conditions
Obesity, Overweight
Interventions
Fruits and Vegetables, Whole Grain, Control
Other
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Carbohydrate Type and Cardiovascular Disease (CVD) Risk Indicators

NCT01610661
View directory record Official record
Conditions
Dyslipidemia
Interventions
Diet
Other
Lead sponsor
Tufts University
Other
Eligibility
50 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Sep 3, 2026, 9:57 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Processing Responses of Grains (PRO-Grains) Study

NCT02186353
View directory record Official record
Conditions
Insulin Resistance, Cardiovascular Disease, Diabetes
Interventions
Partial feeding study
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Sep 3, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pharmacokinetic (PK) Study of Phytochemicals in Whole Grains (WGs)- Corn

NCT07767162
View directory record Official record
Conditions
Healthy Adult Females, Healthy Adult Males
Interventions
Whole-Grain Corn, Refined Corn
Dietary Supplement
Lead sponsor
North Carolina Agriculture & Technical State University
Other
Eligibility
25 Years to 70 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Effect of Whole Grain Diet on Insulin Sensitivity, Advanced Glycation End Products and Inflammatory Markers in Pre-diabetes

NCT01248286
View directory record Official record
Conditions
Diabetes, Prediabetes
Interventions
Whole grain rice, Refined grain rice
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2013 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Phase 3 Interventional

Workplace-Sponsored Diet and Exercise Program to Reduce Obesity

NCT00123526
View directory record Official record
Conditions
Obesity, Cardiovascular Diseases, Heart Diseases
Interventions
Diet, Physical Activity
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 65 Years
Enrollment
899 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 23, 2013 · Synced Sep 3, 2026, 9:57 PM EDT
Terminated Not applicable Interventional

Effects of Whole Food, Plant-Based Nutrition on Chronic Kidney Disease With Proteinuria

NCT04171778
View directory record Official record
Conditions
Chronic Kidney Disease Stage 3B, Chronic Kidney Disease, Stage 4, Proteinuria
Interventions
whole food, plant-based diet
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Sep 3, 2026, 9:57 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Personalized GI Motility Responses to Diet

NCT06386471
View directory record Official record
Conditions
Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction, Cardiovascular Diseases, Dysbiosis
Interventions
Whole grain rye bread, Refined grain rye bread
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
21 Years to 63 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Satiety Effects of the Combination of Egg and Whole Grains

NCT02272153
View directory record Official record
Conditions
Food Selection
Interventions
Egg refined grain, Egg Whole Grain, Cereal Refined grain
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 14, 2015 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Effects of White Potato Consumption on Measures of Cardiometabolic Health in Individuals With Type 2 Diabetes Mellitus

NCT04511325
View directory record Official record
Conditions
Type2 Diabetes, Cardiometabolic Syndrome, Arterial Stiffness, Overweight and Obesity
Interventions
Potato Regimen, Refined Grain Regimen
Other
Lead sponsor
Florida State University
Other
Eligibility
45 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Sep 7, 2022 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Fasting Mimicking Diet

NCT04150159
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
FMD Arm
Dietary Supplement
Lead sponsor
Hypertension Institute, Nashville
Other
Eligibility
35 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Beta-cryptoxanthin Bioavailability From Biofortified Maize in Humans

NCT02800408
View directory record Official record
Conditions
β-cryptoxanthin Bioavailability From Biofortified Maize in Humans
Interventions
Whole grain high-BCX maize, Refined grain high-BCX maize, Whole grain white maize
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
20 Years to 28 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 23, 2019 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Whole Grains, Gastric Emptying and Glycemic Response

NCT03467659
View directory record Official record
Conditions
Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior
Interventions
Cracked whole wheat porridge, Semolina wheat porridge, Whole wheat flour porridge, Refined wheat flour porridge, Refined wheat flour porridge,fine bran, Refined wheat flour porridge,coarse bran
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 18, 2018 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Replacing Starchy Vegetables and Refined Grains With Beef on Cardio-metabolic Disease Risk Factors (S53)

NCT03925142
View directory record Official record
Conditions
Diet Modification
Interventions
Controlled healthy vegetarian diet, Controlled beef diet
Other
Lead sponsor
Purdue University
Other
Eligibility
30 Years to 69 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 7, 2021 · Synced Sep 3, 2026, 9:57 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Health Effects of Grain Foods in Adults

NCT06339879
View directory record Official record
Conditions
High Whole Grain and Low Sugar, Medium Whole Grain and Low Sugar, Low Whole Grain and Low Sugar, Low Whole Grain and High Sugar
Interventions
High Whole Grain, Low Sugar, Low Whole Grain, Low Sugar, High Whole Grain, High Sugar, Low Whole Grain, High Sugar
Other
Lead sponsor
Purdue University
Other
Eligibility
21 Years to 60 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 14, 2024 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Grains Reduce Adiposity and Improve Nutrition Study

NCT00924521
View directory record Official record
Conditions
Metabolic Syndrome, Insulin Resistance
Interventions
Whole grain diet, Refined grain
Dietary Supplement
Lead sponsor
Penn State University
Other
Eligibility
35 Years to 55 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mediterranean-like Unprocessed (CLEAN-MED) Diet Intervention Study of the Gut Microbiome of Healthy Adults

NCT05411120
View directory record Official record
Conditions
Diet Therapy
Interventions
Western Diet, CLEAN-MED
Other
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 60 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional

Remotely Delivered Behavioral Weight Loss Using an Ad Libitum Plant-Based Diet Versus a Balanced Calorie Deficit Diet

NCT05337150
View directory record Official record
Conditions
Obesity, Overweight
Interventions
Lifestyle Modification Intervention, Balanced Calorie Deficit Eating Plan, Ad Libitum Whole Food Plant-Based Eating Plan
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 75 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Sep 3, 2026, 9:57 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Nutrient Profile and Muscle Protein Synthesis in Response to Corn Bread Made From Refined Versus Whole Grain Maize Flour

NCT06662214
View directory record Official record
Conditions
Effect of Food
Interventions
Refined maize flour, Whole grain flour
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 30 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 3, 2026, 9:57 PM EDT
Active, not recruiting Not applicable Interventional

Whole-Food Plant-Based Diet to Control Weight and MetaboInflammation in Overweight/Obese Men With Prostate Cancer

NCT05471414
View directory record Official record
Conditions
Prostate Cancer
Interventions
Whole-food, Plant-Based Diet, General Nutritional Counseling
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
45 Years to 99 Years · Male only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Baltimore, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Diet on Pregnancy Outcome and Child Obesity

NCT03232762
View directory record Official record
Conditions
Pregnancy Related, Diet Modification, Obesity, Hypertension, Pre-Eclampsia, Blood Pressure, Breast Feeding, Birth Weight
Interventions
Refined Grains, Whole Grains
Dietary Supplement
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
303 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Sep 3, 2026, 9:57 PM EDT
Not listed Not applicable Interventional

Can Lifestyle Changes Reverse Early-Stage Alzheimer's Disease

NCT04606420
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Lifestyle medicine
Behavioral
Lead sponsor
Preventive Medicine Research Institute
Other
Eligibility
45 Years to 90 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
4
States / cities
San Diego, California • Sausalito, California • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Sep 3, 2026, 9:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Liking, Acceptability and Health Benefits of Grain Products

NCT01403857
View directory record Official record
Conditions
Food Preferences
Interventions
Whole grain foods, Refined grains
Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
20 Years to 45 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Sep 3, 2026, 9:57 PM EDT