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ClinicalTrials.gov public records Last synced Nov 12, 2026, 12:09 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 31 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Regular Fluoride Toothpaste Clear all

Conditions: Gingival Inflammation
Interventions: Stannous Fluoride Toothpaste (SnF); Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Dentin Hypersensitivity
Interventions: Test Toothpaste 1, Test Toothpaste 2, Reference Toothpaste; Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 254 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Plaque, Dental, Gingivitis
Interventions: Colgate SNaP Total 10/10, 1.5 Taurate, Colgate Great Regular Flavor Toothpaste, Flat Trimmed Extra Clean TB; Drug · Other
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 85 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Costa Mesa, California

Conditions: Dental Plaque
Interventions: Sodium Monofluorophosphate, Triclosan/Fluoride/Copolymer; Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 1
States / cities: New York, New York

Conditions: Dry Socket, Wound Infection
Interventions: Colgate Total Toothpaste, Colgate Regular Toothpaste; Other
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years to 35 Years
Enrollment: 141 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Dental Health
Interventions: Potassium Oxylate Mouthwash, Sodium Fluoride Dentifrice; Device · Drug
Lead sponsor: Johnson & Johnson Consumer and Personal Products Worldwide; Industry
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Paramus, New Jersey

Conditions: Gingival Diseases
Interventions: Fluoride, Triclosan and fluoride, Herbal Ingredient and fluoride; Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 103 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Tooth Stain
Interventions: Colgate® Regular Cavity Protection, Experimental Mouth Rinse, Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint; Drug · Other
Lead sponsor: Johnson & Johnson Consumer and Personal Products Worldwide; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 227 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Tooth Discoloration
Interventions: Whitening Toothpaste, Experimental Mouthwash, Regular Fluoride Toothpaste; Drug · Device
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Melbourne, Florida

Conditions: Dental Plaque, Gingivitis
Interventions: Stannous Fluoride Toothpaste (Parodontax Complete Protection Toothpaste), CPC Mouthwash (Parodontax Active Gum Health Mouthwash), Regular Fluoride Toothpaste (Crest Cavity Protection); Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years and older
Enrollment: 199 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Xerostomia
Interventions: HYDRAL Oral Rinse, BIOTENE® Oral Rinse, Placebo Oral Rinse; Device
Lead sponsor: Sunstar Americas; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Oral Health
Interventions: Stannous Fluoride Toothpaste (Sensodyne Repair and Protect), Regular Fluoride Toothpaste (Colgate Cavity Protection); Other
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Dentin Sensitivity
Interventions: Mouth Rinse, Fluoride Toothpaste, Potassium Nitrate Toothpaste; Device · Drug
Lead sponsor: Johnson & Johnson Consumer and Personal Products Worldwide; Industry
Eligibility: 18 Years and older
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Dental White Spots, Dental Caries
Interventions: CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste, 1,100pm F-toothpaste and 0.5%NaF rinse; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 11 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Dental Caries
Interventions: Caries prevention active intervention, control treatment; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 12 Years to 65 Years
Enrollment: 460 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Oral Bacteria Levels in the Mouth
Interventions: Total Flavor option 1, Total Flavor option 2, Placebo toothpaste: Crest Cavity Protection toothpaste; Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 22 Years to 58 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Newark, New Jersey

Conditions: Gingival Diseases
Interventions: Fluoride, Fluoride, triclosan; Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 26 Years to 68 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Initial Caries, Arrested Dental Caries, Cavitated Caries, Dental Caries, Dental Caries in Children
Interventions: Curodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant, Fluoride varnish, Fluoride toothpaste; Drug · Device
Lead sponsor: CareQuest Institute for Oral Health; Other
Eligibility: 4 Years and older
Enrollment: 744 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 4
States / cities: Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more

Conditions: Oral Hygiene
Interventions: Experimental Dentifrice 1, Experimental Dentifrice 2, Reference Dentifrice; Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 280 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Melbourne, Florida

Conditions: Dentin Sensitivity
Interventions: Stannous fluoride toothpaste, Crest cavity protection toothpaste; Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Dentin Sensitivity
Interventions: Stannous fluoride toothpaste, Regular fluoride toothpaste (Crest Cavity Protection); Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 115 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Melbourne, Florida

Conditions: Dentinal Hypersensitivity
Interventions: Colgate SNF, Sensodyne Extra Whitening, Colgate Fluoride (CDC); Drug
Lead sponsor: Colgate Palmolive; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 123 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Costa Mesa, California

Conditions: Dental Plaque, Gingivitis
Interventions: Test Dentifrice, Parodontax Complete Protection, Colgate Cavity Protection; Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years and older
Enrollment: 284 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Conditions: Dental Plaque, Gingivitis
Interventions: Test Dentifrice, Reference Dentifrice (Colgate Cavity Protection Dentifrice); Drug
Lead sponsor: HALEON; Industry
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Fort Wayne, Indiana

Search by objective public record fields.

Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.

A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes

To Assess the Efficacy of Two Brushing Regimens: in the Reduction of Established Dental Plaque and Gingivitis.

Investigation of Dental Plaque and Gingival Index

Triclosan Toothpaste and Third Molar Surgery

Oral Tissue Tolerance of a Mouthrinse

Compare the Clinical Efficacy of Prototype Toothpastes.

A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal

A Study to Assess the Efficacy of an Experimental Mouthwash Used With a Marketed Whitening Toothpaste on Stain Build-up

A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation

Clinical Evaluation of Oral Rinse for Xerostomia

A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome

A Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity

MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study

CAMBRA - PBRN Caries Management By Risk Assessment In A Practice-Based Research Network

Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria

Collection of Gingival Crevicular Fluid From Periodontitis Patients

Early Caries Lesion Management Observational Study

Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks

Clinical Study to Evaluate the Anti-sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers

A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers

Dentinal Hypersensitivity Reduction

A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation

A Study to Investigate the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health