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Conditions: Peripheral Arterial Disease
Interventions: Advanta VXT Vascular Graft, Flixene Vascular Graft; Device
Lead sponsor: Atrium Medical Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pelvic Organ Prolapse
Interventions: LigaSureTM vessel sealing device; Device
Lead sponsor: Marlana McDowell; Other
Eligibility: 18 Years to 80 Years · Female only
Enrollment: 95 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Cincinnati, Ohio

Conditions: ATFL, Lateral Ankle Instability, Anterior Talofibular Ligament, Anterior Talofibular Ligament Injury, Brostrom Procedure, Brostrom, Ankle
Interventions: Brostrom repair with augmentation, Brostrom repair without augmentation; Device · Other
Lead sponsor: Hancock Orthopedics; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Greenfield, Indiana

Conditions: Pararenal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm
Interventions: PMEG; Device
Lead sponsor: Konstantinos Dean Arnaoutakis, MD; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2029
U.S. locations: 2
States / cities: Tampa, Florida

Conditions: Cartilage Repair
Interventions: Particulated Juvenile Cartilage Allograft; Biological
Lead sponsor: Zimmer Orthobiologics, Inc.; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 3
States / cities: Chicago, Illinois • Indianapolis, Indiana • Albuquerque, New Mexico

Conditions: Varicocele, Male Infertility, Hypospermatogenesis, Non-Obstructive Azoospermia
Interventions: Varicocele repair; Procedure
Lead sponsor: National Institute of Environmental Health Sciences (NIEHS); NIH
Eligibility: 21 Years to 55 Years · Male only
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2005
U.S. locations: 2
States / cities: Camden, New Jersey • Manhasset, New York

Conditions: Breast Cancer, Prostate Cancer, Colorectal Cancer
Interventions: Project HEAL, Project HEAL 2.0; Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years and older
Enrollment: 446 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: College Park, Maryland

Conditions: Peripheral Nerve Injury, Peripheral Nerve Discontinuity, Mixed Peripheral Nerve Injury, Motor Peripheral Nerve Injury, Upper Extremity Nerve Injury
Interventions: Avance Nerve Graft, Sural nerve autograft; Biological · Procedure
Lead sponsor: Axogen Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Solid Tumor, Adult
Interventions: GAd-209-FSP low dose, MVA-209-FSP low dose, GAd-209-FSP high dose, MVA-209-FSP high dose, GAd20-209-FSP, RP2D, MVA-209-FSP, RP2D, KEYTRUDA®; Biological · Drug
Lead sponsor: Nouscom SRL; Industry
Eligibility: 18 Years and older
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 13
States / cities: Duarte, California • Irvine, California • Los Angeles, California + 9 more

Conditions: Rotator Cuff Tear, Postoperative Pain
Interventions: Liposomal bupivacaine (LB); Drug
Lead sponsor: Orthopaedic & Neurosurgery Specialists; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Greenwich, Connecticut

Conditions: Anterior Cruciate Ligament Injury, Rotator Cuff Tear
Interventions: EZ Pass Suture Passer; Procedure
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Ventral Hernia, Umbilical Hernia, Incisional Hernia, Postoperative Complications, Pain, Postoperative
Interventions: Transabdominal Plane Block, Non Transabdominal Plane Block; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 127 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Congenital Diaphragmatic Hernia
Interventions: Repair of CDH w/SIS Gold, Repair of CDH w/Alloderm; Procedure
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: Up to 2 Months
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Mitral Valve Regurgitation, Congestive Heart Failure, Cardiomyopathy
Interventions: 3 dimensional echocardiography; Procedure
Lead sponsor: Juan Crestanello, MD; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Rotator Cuff Tear Arthropathy
Interventions: Ibuprofen, Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Cerebrospinal Fluid Leak
Interventions: FS VH S/D 500 s-apr, DuraSeal Dural Sealant; Drug · Device
Lead sponsor: Baxter Healthcare Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 224 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 10
States / cities: Springfield, Illinois • Springfield, Massachusetts • Detroit, Michigan + 7 more

Conditions: Epithelial Ovarian Cancer, Primary Peritoneal, Fallopian Tube Cancer, Newly Diagnosed, FIGO Stage III-IV, Partial Response, Complete Response
Interventions: Rucaparib, Nivolumab, Placebo Oral Tablet, Placebo IV Infusion; Drug
Lead sponsor: pharmaand GmbH; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 1,097 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2030
U.S. locations: 64
States / cities: Phoenix, Arizona • Tucson, Arizona • Concord, California + 55 more

Conditions: Wound Heal, Oral Microbiome
Interventions: cetylpyridinium chloride; Other
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 18 Years to 45 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis Relapse, Multiple Sclerosis Brain Lesion, Multiple Sclerosis Benign
Interventions: Clemastine Fumarate, Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 55 Years
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Wounds, Wound of Skin, Wound Heal, Wounds and Injuries
Interventions: 4-Aminopyridine, Placebo; Drug · Other
Lead sponsor: John Elfar; Other
Eligibility: 18 Years to 70 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Inguinal Hernia
Interventions: Open Inguinal Hernia Repair, Laparoscopic Inguinal Hernia Repair, Robotic-Assisted Inguinal Hernia Repair; Procedure · Device
Lead sponsor: Intuitive Surgical; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Healthy
Interventions: Ointment Vehicle, Xenaderm; Other · Drug
Lead sponsor: Healthpoint; Industry
Eligibility: 18 Years and older
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Cellular Injury and Post-Cryogenic Recovery, Cryogenic Cellular Stress, Cold-Induced Cellular Injury, Thermal Injury Response, Post-Thaw Viability Impairment, Osmotic Stress Injury, Biomechanical Injury Modeling (In-Vitro), Blunt Force Injuries to the Extremities (Cellular Injury Model), Tissue Damage and Recovery Pathways, Hypothermic Tissue Stress, Cellular Regeneration and Repair
Interventions: Standard Laboratory Cryopreservation Procedure, Enhanced Laboratory Cryopreservation Procedure, Normothermic Cell Culture Control; Other
Lead sponsor: Truway Health, Inc.; Industry
Eligibility: Not listed
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2066
U.S. locations: 1
States / cities: New York, New York

Conditions: Skin Carcinoma
Interventions: Best Practice, Educational Intervention, Electronic Health Record Review, Follow-Up Care, Medical Device Usage and Evaluation, Negative Pressure Wound Therapy, Photography, Questionnaire Administration; Other · Procedure
Lead sponsor: Jonsson Comprehensive Cancer Center; Other
Eligibility: 19 Years to 79 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Los Angeles, California

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Advanta VXT and Flixene PMCF Registry

Comparing Postoperative Pain After Vessel Sealing Device Versus Conventional Suturing Methods for Vaginal Hysterectomy and Pelvic Reconstructive Surgery

BioBrace® in Arthroscopic Brostrom Lateral Ankle Ligament Repair

PMEG for Repair of Pararenal and Thoracoabdominal Aortic Aneurysm

Post Market Study of DeNovo NT, Natural Tissue Graft

Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele

Integration of Cancer Health Activities Into African American Churches

A Prospective, Randomized, Assessor-Blinded, Multicenter Study Comparing Avance Nerve Graft and Autograft for Functional Recovery Following Mixed and Motor Peripheral Nerve Reconstruction

Nous-209 Genetic Vaccine for the Treatment of Microsatellite Unstable Solid Tumors

Liposomal Bupivacaine for Pain Control After Rotator Cuff Repair

MDR EZ Pass and Precision Flexible Reamer

Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair?

Type of Material in Repair of Congenital Diaphragmatic Hernia

Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy

Effect of Ibuprofen on Postoperative Opiate Medication Use and Shoulder Functional Outcomes

Efficacy and Safety of FS VH S/D 500 S-apr (Tisseel) as an Adjunct to Sutured Dural Repair in Cranial Surgery

A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy

Effect of Mouthwashes on Oral Wound Healing and Microbiome

Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy

4-aminopyridine for Skin Wound Healing

Pain and Quality of Life After Inguinal Hernia Repair

Clinical Evaluation of the Photoallergy Potential of Xenaderm Ointment

Evaluation of In-Vitro Cryo Therapeutic Protocols on Human Cell Samples (TWH-CRYO-001)

A Disposable Negative Pressure Wound Therapy Device (SNaP) to Promote Wound Healing in the Lower Limbs Following Mohs Micrographic Surgery for Non-melanoma Skin Cancer