Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 24, 2026, 9:57 AM EDT

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Showing 1–24 of 148 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Cardiovascular Disease, Obesity, Physical Disability
Interventions
Caloric restriction, Aerobic Training, Resistance Training
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years to 79 Years
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
3
States / cities
Kernersville, North Carolina • Winston-Salem, North Carolina
Conditions
HIV Infections
Interventions
Use of creatine monohydrate (a dietary supplement), Progressive resistance exercise training
Procedure · Behavioral
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2003
U.S. locations
1
States / cities
San Francisco, California
Conditions
Obesity, Cardiovascular Diseases
Interventions
Diet, Diet Plus Aerobic Training, Diet plus Resistance Training
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
30 Years to 55 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Obesity
Interventions
Exercise program, Nutrition, WLS
Behavioral · Dietary Supplement · Procedure
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
55 Years to 75 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Breast Cancer
Interventions
Nutrition and resistance training exercise intervention
Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
20 Years to 89 Years · Female only
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors

NCT04221750
Conditions
Frailty, Sarcopenic Obesity, Aging
Interventions
Lifestyle therapy, Metformin Hydrochloride, Placebo, Healthy Lifestyle
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Houston, Texas
Conditions
Muscle Mass and Strength
Interventions
Resistance Exercise Program, Nutrition and Exercise Counseling
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Male only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers Results available

Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults

NCT02261961
Conditions
Sarcopenia, Aging, Immune Function
Interventions
TDAP, Acute Resistance Exercise, Resistance Exercise Training, Post-training Follow-up, Nutritional Supplement (Muscle Armor), Placebo (Kool-Aid)
Biological · Other · Dietary Supplement
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 80 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
North Little Rock, Arkansas
Conditions
Cancer, Breast Cancer
Interventions
Whey protein (60 grams), No protein
Dietary Supplement · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
20 Years to 89 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers

Nutrient Timing Following Resistance Exercise

NCT01674049
Conditions
Type 2 Diabetes
Interventions
Immediate Nutrition, Nutrition 3 hours Post-Bout, Resistance Exercise
Dietary Supplement · Other
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Conditions
Obesity, Overweight
Interventions
Whey Protein, Whey Protein and Resistance Exericse, Whey Protein and RISE exercise routine
Dietary Supplement · Other
Lead sponsor
Skidmore College
Other
Eligibility
30 Years to 60 Years
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Saratoga Springs, New York
Conditions
Polycystic Ovary Syndrome
Interventions
Metformin, Oral Contraceptive Pill, Lifestyle Management Program, Quality of Life Questionnaire, Oral Glucose Tolerance Test, Blood work, Abdominal Ultra Sound, Dual-energy x-ray absorptiometry (DEXA scan), placebo
Drug · Behavioral · Procedure
Lead sponsor
University of Rochester
Other
Eligibility
12 Years to 18 Years · Female only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Rochester, New York
Completed Not applicable Interventional Accepts healthy volunteers

Exercise-Induced Epigenetic Modifications in Obese Aging Women

NCT01977885
Conditions
Metabolic Syndrome
Interventions
High Protein Diet, Exercise
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
50 Years to 64 Years · Female only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Athens, Georgia
Conditions
Knee Osteoarthritis
Interventions
Dietary Weight-loss, Exercise
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
318 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2000
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Conditions
Indolent Lymphomas, Lymphoma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Follicular Lymphoma, Marginal Zone Lymphoma, Lymphoplasmacytic Lymphoma, Waldenstrom Macroglobulinemia, Cutaneous T Cell Lymphoma
Interventions
Exercise, Diet
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Conditions
Moderate-severe Chronic Kidney Disease Not Treated With Dialysis, Diabetic Kidney Disease, HgbA1c Less Than 8.5
Interventions
Combined Aerobic and Resistance Exercise via videoconferencing
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
30 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Sacramento, California
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Optimizing Body Composition for Function in Older Adults

NCT00315146
Conditions
Obesity, Overweight With Indications for Weight Loss
Interventions
Pioglitazone, Resistance exercise training to maximize muscle power, Hypocaloric diet, Placebo
Drug · Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years to 79 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Conditions
Philadelphia Chromosome Negative, B Cell Acute Lymphoblastic Leukemia (B-ALL), B-ALL
Interventions
Nutrition Intervention, Exercise intervention
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Aging
Interventions
Resistance Training Exercise, Beef Protein Consumption
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
40 Years to 64 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Urbana, Illinois
Completed Not applicable Interventional Accepts healthy volunteers

Improving Muscle for Functional Independence Trial

NCT01049698
Conditions
Obesity
Interventions
Resistance Training, Resistance Training + Diet
Behavioral
Lead sponsor
Wake Forest University
Other
Eligibility
65 Years to 79 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Conditions
Obesity and Overweight
Interventions
Standard Medical Care (SMC), Monitoring Contacts, Aerobic Training, Resistance Training, Nutrition Education
Other · Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Conditions
Obesity & Overweight, Sarcopenia
Interventions
High Protein Diet Counceling, Standard Protein Diet Counceling, Protein Supplement, Supervised Exercise
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
50 Years to 75 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Resistance Training, Caffeine, Dietary Supplements
Interventions
Caffeinated pre-workout supplement, Non-caffeinated pre-workout supplement, Placebo
Dietary Supplement
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Lubbock, Texas
Conditions
Pancreatic Cancer
Interventions
Nutritional Counseling, Standard Exercise, Enhanced Exercise
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
30 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma