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ClinicalTrials.gov public records Last synced Nov 11, 2026, 11:40 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 668 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Restricted Diet Clear all

Conditions: Osteoarthritis, Knee
Interventions: Diet and Exercise; Behavioral
Lead sponsor: Wake Forest University; Other
Eligibility: 50 Years and older · Female only
Enrollment: 1,230 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2029
U.S. locations: 3
States / cities: Boston, Massachusetts • Chapel Hill, North Carolina • Winston-Salem, North Carolina

Conditions: Weight Loss, Blood Pressure, Lipid Disorder, PreDiabetes, Diabete Mellitus
Interventions: Low-fat plant-based diet; Behavioral
Lead sponsor: Physicians Committee for Responsible Medicine; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Obesity & Overweight, Cardiometabolic Risk Factors
Interventions: Mediterranean eating style, Physical activity, Mindful Eating, Body Appreciation, Enjoyable Exercise; Behavioral
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Bipolar I Disorder, Psychosis, Schizoaffective Disorder
Interventions: Ketogenic diet, Dietary Guidelines for Americans; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Chronic Tonsillitis, Sleep Disordered Breathing
Interventions: Diet modification; Other
Lead sponsor: Georgetown University; Other
Eligibility: 3 Years to 12 Years
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Obesity, Insulin Resistance
Interventions: Low glycemic index diet, Low fat diet, Very low carbohydrate diet; Other
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 40 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Obesity
Interventions: Low- Carbohydrate -Atkins Diet, Low Calorie Diet; Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2009
U.S. locations: 3
States / cities: Denver, Colorado • St Louis, Missouri • Philadelphia, Pennsylvania

Conditions: Ascites
Interventions: Sodium restriction; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Prostate Cancer Recurrent
Interventions: Low protein diet, Control protein diet; Other
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older · Male only
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 2
States / cities: Indianapolis, Indiana

Conditions: Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Carcinoma, Metastatic Malignant Neoplasm in the Brain, Stage IV Lung Cancer AJCC v8
Interventions: Behavioral Dietary Intervention, Text Message-Based Navigation Intervention, Internet-Based Intervention, Dietary Counseling and Surveillance, Stereotactic Radiosurgery, Biospecimen Collection, Magnetic Resonance Imaging, Neurocognitive Assessment, Questionnaire Administration, Interview; Behavioral · Other · Radiation + 1 more
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Obesity
Interventions: Alternate Day Intermittent Energy Restriction, Reduced Calorie Diet; Other
Lead sponsor: Texas Tech University; Other
Eligibility: 18 Years to 25 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 2
States / cities: Lubbock, Texas

Conditions: Obesity, Overweight, Metabolic Diseases
Interventions: Low Calorie Diet (LCD), Phentermine; Behavioral · Drug
Lead sponsor: AdventHealth Translational Research Institute; Other
Eligibility: 18 Years to 55 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Calorie Restriction
Interventions: Not listed
Lead sponsor: Tufts University; Other
Eligibility: 33 Years to 70 Years
Enrollment: 216 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 3
States / cities: Baton Rouge, Louisiana • Boston, Massachusetts • St Louis, Missouri

Conditions: Dietary Modification, Kidney Diseases, Chronic
Interventions: Usual protein and phosphorus diet, Low protein and phosphorus diet, Very low protein and phosphorus; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years to 70 Years
Enrollment: 840 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1988 – 2016
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Obesity
Interventions: Low carbohydrate diet, Moderate carbohydrate diet, High carbohydrate diet; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 4
States / cities: Boston, Massachusetts • Framingham, Massachusetts

Conditions: Ketogenic Dieting
Interventions: Carbohydrate Supplement (Carb10), Diet, Exercise; Dietary Supplement · Other
Lead sponsor: Texas Woman's University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Denton, Texas

Conditions: Prostate Cancer
Interventions: Fish Oil, Vitamin E supplement, Western Diet, Low-Fat Diet, Medical Examination, Dietary Interview, Blood Draw, Radical Prostatectomy; Dietary Supplement · Other · Procedure
Lead sponsor: Jonsson Comprehensive Cancer Center; Other
Eligibility: 40 Years to 75 Years · Male only
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2018
U.S. locations: 2
States / cities: Los Angeles, California

Conditions: Weight Loss, Pediatric Obesity, Overweight Adolescents, Parent-Child Relations, Family and Household
Interventions: Brenner FIT Standard, By Design Essentials, Dyad Plus; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 13 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Weight Management
Interventions: one-hour dietary self-monitoring tool education session; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Obesity, Body Weight
Interventions: Early Time-Restricted Eating, Conventional dietary regimen (12-hr, 9:30a-9:30p); Behavioral
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Obesity
Interventions: low glycemic load diet, low fat diet; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 35 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Rheumatoid Arthritis (RA), Crohn's Disease (CD), Ulcerative Colitis (UC)
Interventions: Ketogenic diet, Carnivore (Lion) Diet; Behavioral
Lead sponsor: Fuller Research Foundation; Other
Eligibility: 18 Years to 64 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Diabetes Mellitus, Type 1
Interventions: Ketogenic Diet, Standard Diet; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Sleep Deprivation
Interventions: Sleep Deprivation, Heart Rate, Sleep Monitoring, Diet, Exercise Performance, Surveys, McGill Pain Questionnaire, Shortened Profile of Mood States, Pittsburg Sleep Index, Cognitive performance, Marksmanship Performance, Quick Board, Advanced Medical Technologies Inc, Jump Test, CGM/CKM, Blood Draw, Ketone Supplement; Other · Behavioral · Biological + 1 more
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Search by objective public record fields.

The Osteoarthritis Prevention Study

Feasibility & Implementation of a Plant-Based Weight-Loss Program in an Office-Based Setting

Pilot Test of Five Weight Neutral Interventions to Improve Health Among Adults of Higher Body Weight

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

Outcomes of Post-operative Diet in Children Following Tonsillectomy and Adenoidectomy

Popular Diets Study

The Safety and Efficacy of Low and High Carbohydrate Diets

Sodium Restriction in the Management of Cirrhotic Ascites

Sipuleucel-T and Low-protein Diet in Patients With Metastatic Castrate-resistant Prostate Cancer

An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer

Effect of a 4-week Alternate Day Intermittent Energy Restriction Intervention vs Reduced

Effect of Caloric Restriction on Fat Oxidation in Obese Men and Women (Magellan II)

The CALERIE™ Legacy Study

Metabolomics for Identifying Biomarkers of Dietary Intake and Kidney Disease Progression

Metabolic Fuels Study

Determining the Ergogenic Effects of Carb10™ Supplementation on Carbohydrate-Rich and Carbohydrate-Restricted Diets

Low-Fat Fish Oil Diet for Prostate Cancer Prevention

Dyad Plus Effectiveness/Feasibility

Education Session to Improve Program Adherence

Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation

An 18-month Trial of a Low Glycemic Load Diet

Ketogenic and Carnivore (Lion) Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis

Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes

Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction