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ClinicalTrials.gov public records Last synced Oct 24, 2026, 7:59 PM EDT

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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Restylane Treatment Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

Restylane Silk Acne Scar Efficacy Evaluation Study

NCT02955381
View directory record Official record
Conditions
Acne, Acne Scars, AdverseEvent
Interventions
Restylane Silk, 1.0 ml, Saline, 1.0 ml
Device
Lead sponsor
Schweiger Dermatology, PLLC
Industry
Eligibility
22 Years to 55 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 10, 2019 · Synced Oct 24, 2026, 7:59 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study to Evaluate the Safety of Retreatment With Restylane® Lyft With Lidocaine for Augmentation of the Chin Region

NCT07566286
View directory record Official record
Conditions
Chin Augmentation
Interventions
Restylane Lyft with Lidocaine
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
8
States / cities
Westport, Connecticut • Boynton Beach, Florida • Coral Gables, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Safety and Effectiveness of Aquamid as Compared to Restylane for the Aesthetic Treatment of Nasolabial Folds

NCT00407914
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Aquamid, Restylane
Device
Lead sponsor
Contura
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2009 · Synced Oct 24, 2026, 7:59 PM EDT
Active, not recruiting Not applicable Interventional

Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin

NCT06195605
View directory record Official record
Conditions
Photoaging
Interventions
Restylane-L, Vehicle
Device
Lead sponsor
University of Michigan
Other
Eligibility
30 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Results available

Restylane Defyne in a Stepwise Treatment Approach

NCT04520997
View directory record Official record
Conditions
Lower Face Folds and Lines
Interventions
Restylane Defyne
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Birmingham, Alabama • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Oct 24, 2026, 7:59 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Platelet Rich Fibrin for Tear Trough Rejuvenation

NCT03313934
View directory record Official record
Conditions
Tear Trough Hollowing, Under Eye Bags
Interventions
Hyaluronic Acid Filler and Platelet Rich Fibrin (PRF), Hyaluronic Acid Filler and Saline
Combination Product
Lead sponsor
Rejuva Medical Aesthetics
Other
Eligibility
20 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 18, 2017 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Ultrasound Analysis of Two Hyaluronic Acid Dermal Fillers

NCT05622851
View directory record Official record
Conditions
Volume Deficiency of the Midface
Interventions
Restylane Contour, Juvederm Voluma
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Santa Rosa Beach, Florida
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 24, 2026, 7:59 PM EDT
Completed No phase listed Observational

Outcomes and Patient Experience After Soft Tissue Dermal Filler Injections

NCT01034956
View directory record Official record
Conditions
Rhytids, Wrinkles
Interventions
hyaluronic acid or calcium hydroxylapatite filler
Device
Lead sponsor
The New York Eye & Ear Infirmary
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2012 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effectiveness and Safety of Restylane Lyft With Lidocaine in the Dorsal Hand

NCT02650921
View directory record Official record
Conditions
Volume Deficit in the Hand
Interventions
Restylane Lyft with Lidocaine
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
7
States / cities
Vista, California • Boulder, Colorado • Englewood, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 24, 2026, 7:59 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Micro-injections of Transparent Hyaluronic Acid Gel (Restylane® Silk) for Rejuvenation of the Aging Cheek

NCT03461198
View directory record Official record
Conditions
Wrinkle
Interventions
Restylane® Silk
Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 3, 2019 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Results available

Safety/Efficacy Study of Restylane® in Lip Augmentation

NCT00935272
View directory record Official record
Conditions
Lip Augmentation
Interventions
Restylane®, Non-Treatment
Device
Lead sponsor
Medicis Global Service Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
12
States / cities
San Diego, California • San Francisco, California • Santa Monica, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2012 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Restylane Refyne for Correction of Horizontal Neck Rhytides

NCT04162496
View directory record Official record
Conditions
Aging, Wrinkle, Rhytides
Interventions
Restylane Refyne
Device
Lead sponsor
Siperstein Dermatology
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boynton Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies

NCT06351358
View directory record Official record
Conditions
Photoaging, Weight Loss, Skin Laxity, Photodamaged Skin, Volume Deficiency of the Midface
Interventions
Sculptra treatment, Restylane Treatment
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Washington D.C., District of Columbia • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Results available

Restylane-L for Correction of Infraorbital Hollows

NCT04154930
View directory record Official record
Conditions
Infraorbital Hollows
Interventions
Restylane-L®
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
16
States / cities
Encino, California • Los Angeles, California • Redondo Beach, California + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Study of JUVÉDERM VOLBELLA® XC Injectable Gel for Lip and Perioral Enhancement

NCT01998581
View directory record Official record
Conditions
Subjects Desiring Lip Augmentation
Interventions
JUVEDERM VOLBELLA® XC, Restylane-L®
Device
Lead sponsor
Allergan
Industry
Eligibility
22 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 26, 2019 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Assessment and Augmentation of Lip Appearance in Specific Study Populations

NCT04839692
View directory record Official record
Conditions
Lip Aging, Lip Augmentation, Lip
Interventions
Hyaluronic acid filler
Drug
Lead sponsor
Dieter Manstein, MD
Other
Eligibility
21 Years and older · Female only
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Results available

Effectiveness and Safety of Restylane Contour in the Treatment of Temple Hollowing

NCT05691972
View directory record Official record
Conditions
Temporal Hollowing
Interventions
Restylane Contour
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
15
States / cities
Phoenix, Arizona • Encino, California • Los Angeles, California + 12 more
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 24, 2026, 7:59 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Restylane Silk for Treatment of Chest Wrinkles

NCT03324997
View directory record Official record
Conditions
Wrinkle
Interventions
Restylane Silk, Saline, Optical Coherence Tomography
Drug · Device
Lead sponsor
Heidi Waldorf
Other
Eligibility
25 Years to 55 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 6, 2018 · Synced Oct 24, 2026, 7:59 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

A Clinical Study Comparing Restylane® Silk and Belotero Balance® for the Treatment of Superficial, Vertical Perioral Lines

NCT02818556
View directory record Official record
Conditions
Perioral Rhytids
Interventions
Restalyne Silk, Belotero Balance
Drug
Lead sponsor
The Maas Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2016 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Safety and Efficacy of Restylane Defyne for Chin Augmentation and Correction of Chin Retrusion

NCT03624816
View directory record Official record
Conditions
Chin Retrusion, Chin Augmentation
Interventions
Restylane Defyne
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
11
States / cities
Los Angeles, California • Manhattan Beach, California • Redondo Beach, California + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2022 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Phase 3 Interventional Results available

A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs)

NCT00444626
View directory record Official record
Conditions
Facial Wrinkles at the Nasolabial Folds
Interventions
Dermal Gel Extra (DGE), Restylane, EMLA Cream
Device · Drug
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • La Jolla, California • Miami Beach, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2015 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assess the Impact of Lip Rejuvenation on Projected First Impressions and Mood Perceptions

NCT03241862
View directory record Official record
Conditions
Lip Rejuvenation
Interventions
Restylane® Silk
Device
Lead sponsor
DeNova Research
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Injection Technique Assessment of Restylane Lyft With Lidocaine for Cheek Augmentation

NCT03160716
View directory record Official record
Conditions
Cheek Augmentation, Midface Contour Deficiencies
Interventions
Restylane Lyft with Lidocaine
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
4
States / cities
Beverly Hills, California • Los Angeles, California • Palo Alto, California + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 24, 2026, 7:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds

NCT00797459
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Restylane and Restylane-L
Device
Lead sponsor
Medicis Global Service Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Hunt Valley, Maryland • Mount Kisco, New York
Source: ClinicalTrials.gov public record
Updated Sep 6, 2013 · Synced Oct 24, 2026, 7:59 PM EDT