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ClinicalTrials.gov public records Last synced Oct 28, 2026, 5:12 AM EDT

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Showing 1–24 of 53 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Reverse total shoulder replacement Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigation of Intravenous Tranexamic Acid With Anatomic and Reverse Total Shoulder Arthroplasty

NCT02569658
View directory record Official record
Conditions
Blood Loss, Anatomic Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty, Transfusion, Tranexamic Acid
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 2, 2021 · Synced Oct 28, 2026, 5:12 AM EDT
Completed Not applicable Interventional

The Effect of Music Therapy Intervention on Pain and Anxiety in Adult Patients Undergoing Total Shoulder Arthroplasty

NCT02692768
View directory record Official record
Conditions
Arthritis
Interventions
Live Music Therapy, Recorded Music Therapy, Control
Other
Lead sponsor
April Armstrong
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 20, 2024 · Synced Oct 28, 2026, 5:12 AM EDT
Withdrawn Phase 3 Interventional

Effect of TXA on Blood Loss in Reverse Total Shoulder Arthroplasty

NCT06638749
View directory record Official record
Conditions
Shoulder Arthritis, Blood Loss, Surgical, Tranexamic Acid Adverse Reaction
Interventions
Tranexamic Acid, Normal Saline
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Oct 28, 2026, 5:12 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Reverse Total Shoulder Arthroplasty: A Data Analysis on Patients Undergoing Reverse Total Shoulder Arthroplasty

NCT03617107
View directory record Official record
Conditions
Osteo Arthritis Shoulders, Proximal Humeral Fracture, Rotator Cuff Tear, Rotator Cuff Tear Arthropathy
Interventions
reverse total shoulder arthroplasty
Other
Lead sponsor
The Orthopaedic Research & Innovation Foundation
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Edgewood, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 25, 2019 · Synced Oct 28, 2026, 5:12 AM EDT
Recruiting Not applicable Interventional

Subscapularis Repair Augmentation for Total Shoulder Arthroplasty

NCT05487677
View directory record Official record
Conditions
Shoulder Injuries
Interventions
BioBrace Augmentation, Standard Repair with Sutures
Device · Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 28, 2026, 5:12 AM EDT
Recruiting Not applicable Interventional

A Study Comparing Shoulder Replacement Techniques For Patients With Shoulder Arthritis And An Intact Rotator Cuff

NCT07584356
View directory record Official record
Conditions
Shoulder Arthritis
Interventions
aTSA, rTSA
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years to 85 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 28, 2026, 5:12 AM EDT
Completed No phase listed Observational Results available

Prediction of Development of Scapular Notching Following Reverse Total Shoulder Arthroplasty

NCT02052466
View directory record Official record
Conditions
Osteoarthritis, Rotator Cuff Tear Arthropathy, Reverse Total Shoulder Arthroplasty, Scapular Notching
Interventions
Not listed
Lead sponsor
Eric Ricchetti
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Oct 28, 2026, 5:12 AM EDT
Terminated Not applicable Interventional

Reverse Total Shoulder Arthroplasty Versus Open Reduction Internal Fixation of 3&4 Part Proximal Humerus Fractures

NCT02597972
View directory record Official record
Conditions
Closed Fracture Proximal Humerus, Four Part
Interventions
Fracture repair, Fracture repair with joint replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
70 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Oct 28, 2026, 5:12 AM EDT
Terminated No phase listed Observational Results available

A Post-Market Clinical Evaluation of the ReUnion Reverse Shoulder Arthroplasty (RSA) System

NCT03880955
View directory record Official record
Conditions
Shoulder Arthroplasty
Interventions
ReUnion RSA System
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years to 99 Years
Enrollment
102 participants
Timeline
2019 – 2023
U.S. locations
3
States / cities
Peoria, Illinois • Greenville, South Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Oct 28, 2026, 5:12 AM EDT
Recruiting Phase 4 Interventional

Addition of a Pectoserratus Block to Interscalene Block in Patients Undergoing Total Shoulder Replacement

NCT06143306
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
bupivacaine., Saline
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 85 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 28, 2026, 5:12 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

TSA Versus RSA in Patients >75

NCT04827277
View directory record Official record
Conditions
Total Shoulder Arthoplasty
Interventions
Reverse Total Shoulder Replacement, Anatomic Total Shoulder Replacement
Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
75 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 28, 2026, 5:12 AM EDT
Terminated No phase listed Observational

TITAN™ Reverse Shoulder System

NCT02204228
View directory record Official record
Conditions
Osteoarthritis of the Shoulder
Interventions
TITAN™ Reverse Shoulder System (TRS)
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
7
States / cities
Gainesville, Florida • Columbia, Maryland • Starkville, Mississippi + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 28, 2026, 5:12 AM EDT
Terminated No phase listed Observational Results available

A Post-Market Clinical Evaluation of the ReUnion Reversible Fracture (RFX) System

NCT04089371
View directory record Official record
Conditions
Arthroplasty, Hemiarthroplasty, Shoulder Pain
Interventions
ReUnion Total Shoulder Arthroplasty (TSA), ReUnion Reverse Shoulder Arthroplasty (RSA)
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years to 99 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
3
States / cities
Peoria, Illinois • Greenville, South Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 20, 2025 · Synced Oct 28, 2026, 5:12 AM EDT
Completed Not applicable Interventional

Reverse Shoulder Replacement: Formal vs. Home Physiotherapy

NCT03430167
View directory record Official record
Conditions
Shoulder Arthropathy Associated With Other Conditions
Interventions
home therapy, formal therapy
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
61 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Oct 28, 2026, 5:12 AM EDT
Completed Not applicable Interventional

Home Exercise vs PT for Reverse Total Shoulder Arthroplasty

NCT03719859
View directory record Official record
Conditions
Shoulder Arthritis, Rotator Cuff Tear Arthropathy
Interventions
Physical Therapy, Home Therapy
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
7
States / cities
Denver, Colorado • Washington D.C., District of Columbia • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 28, 2026, 5:12 AM EDT
Recruiting Not applicable Interventional

RSA Vs RCR for Massive RCTs

NCT05807854
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
Arthroscopy, Reverse Shoulder Arthroplasty
Procedure · Device
Lead sponsor
La Tour Hospital
Other
Eligibility
60 Years to 80 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 26, 2024 · Synced Oct 28, 2026, 5:12 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Prospective Low Dose CT for Total Shoulder Arthroplasty/Reverse Shoulder Arthroplasty

NCT05350319
View directory record Official record
Conditions
Shoulder Arthroplasty
Interventions
A low-dose CT scan of the shoulder
Radiation
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 14, 2023 · Synced Oct 28, 2026, 5:12 AM EDT
Completed Not applicable Interventional

Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty

NCT04415931
View directory record Official record
Conditions
Shoulder Osteoarthritis, Cuff Tear Arthropathy, Massive Rotator Cuff Tear
Interventions
Local infiltration analgesia, Interscalene block
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 28, 2026, 5:12 AM EDT
Terminated Not applicable Interventional

RSA vs. Nonop for 3 & 4-Part Proximal Humerus Fractures

NCT03599336
View directory record Official record
Conditions
Humerus Fracture, Humerus, Shoulder Fractures, Shoulder Arthropathy Associated With Other Conditions, Arthropathy Shoulder, Shoulder Injury, Arthropathy
Interventions
Reverse Total Shoulder Arthroplasty (rTSA), Nonoperative Treatment
Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
65 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Oct 28, 2026, 5:12 AM EDT
Not yet recruiting No phase listed Observational

Three Year Outcomes After Shoulder Arthroplasty

NCT07815535
View directory record Official record
Conditions
Arthroplasty, Replacement, Shoulder, Arthritis Shoulder, Rotator Cuff Arthropathy
Interventions
Not listed
Lead sponsor
Vani Sabesan
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
5
States / cities
Atlantis, Florida • North Liberty, Iowa • Leawood, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 28, 2026, 5:12 AM EDT
Recruiting Not applicable Interventional

Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty

NCT06831422
View directory record Official record
Conditions
Shoulder Arthroplasty, Positive C. Acnes Culture
Interventions
Povidone-Iodine, Hydrogen Peroxide, Xperience Antimicrobial Wash, Bacterial Cultures, Shoulder Arthroplasty
Device · Diagnostic Test · Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 28, 2026, 5:12 AM EDT
Enrolling by invitation No phase listed Observational

MDR - Comprehensive Reverse/Versa Dial Ti Glenosphere

NCT04003272
View directory record Official record
Conditions
Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Arthritis, Shoulder Disease
Interventions
Comprehensive Reverse Versa-Dial Titanium Glenosphere
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2035
U.S. locations
2
States / cities
Louisville, Kentucky • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 28, 2026, 5:12 AM EDT
Withdrawn Not applicable Interventional

Subscapularis Repair During Reverse Total Shoulder Arthroplasty

NCT05341518
View directory record Official record
Conditions
Shoulder Osteoarthritis, Arthropathy Shoulder
Interventions
Subscapularis repair
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 88 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Maywood, Illinois • Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 15, 2024 · Synced Oct 28, 2026, 5:12 AM EDT
Recruiting Not applicable Interventional

Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture

NCT06869343
View directory record Official record
Conditions
Orthopedic Disorder, Humerus Fracture, Shoulder Arthroplasty, Reverse Shoulder Replacement
Interventions
Physical Therapy
Other
Lead sponsor
University of Virginia
Other
Eligibility
50 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 28, 2026, 5:12 AM EDT