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ClinicalTrials.gov public records Last synced Oct 21, 2026, 3:57 PM EDT

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Showing 217–240 of 658 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Reward Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

NCT05194098
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil, SHAM (inactive) TMS stimulation
Device
Lead sponsor
San Francisco Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 21, 2026, 3:57 PM EDT
Enrolling by invitation Not applicable Interventional

Pain & Reward Neuromodulation of CNS Circuits

NCT07525063
View directory record Official record
Conditions
Fibromyalgia Syndrome, Fibromyalgia, Chronic Pain and Fatigue
Interventions
Transcranial Magnetic Stimulation (TMS)
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Theory Driven, Rurally Tailored, Family-Based, Telehealth Intervention for Childhood Obesity

NCT04720703
View directory record Official record
Conditions
Childhood Obesity
Interventions
Newsletters, Family-based Telehealth Intervention
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
5 Years to 11 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 2, 2023 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Behavioral Activation, Nutrition, and Activity Intervention

NCT06239961
View directory record Official record
Conditions
HIV
Interventions
Social Connection, Nutritional Coaching, Physical Activity Coaching
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 4, 2025 · Synced Oct 21, 2026, 3:57 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers

NCT06484088
View directory record Official record
Conditions
Irritability
Interventions
Frustration task
Other
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Bethesda, Maryland • College Station, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Continuous Glucose Monitoring, Contingency Management, and Motivational Interviewing for Patients With Type 2 Diabetes in Kansas City

NCT06374186
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Behavioral Intervention with financial rewards and coaching, Control
Behavioral
Lead sponsor
University of Missouri, Kansas City
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 21, 2026, 3:57 PM EDT
Withdrawn No phase listed Observational

Promus - Registry Experience at the Washington Hospital Center, Drug-eluting Stent (DES)

NCT01003795
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Not listed
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 21, 2026, 3:57 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Expression of Stress Markers During Meth Treatment (EXPRESS+)

NCT05558345
View directory record Official record
Conditions
Substance-Related Disorders, HIV
Interventions
Contingency Management
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Organizational Skills Training for Children With Attention Deficit Hyperactivity Disorder

NCT00381407
View directory record Official record
Conditions
Attention Deficit Disorder With Hyperactivity
Interventions
Organizational Skills Training, Contingency management (CM)
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
8 Years to 11 Years
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
2
States / cities
New York, New York • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 19, 2013 · Synced Oct 21, 2026, 3:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Detecting a Reward Signal in the Motor Cortex

NCT00422071
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 60 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

Mobile Contingency Management for Marijuana and Tobacco Cessation

NCT02869451
View directory record Official record
Conditions
Cigarette Smoking, Marijuana Abuse
Interventions
bupropion, transdermal nicotine patch, Nicotine polacrilex, nicotine lozenge, counseling for marijuana and smoking cessation, mobile contingency management
Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 7, 2020 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Phase 1 Interventional

Virtual Reality-Reward Training for Anhedonia

NCT05342077
View directory record Official record
Conditions
Positive Affect, Depression
Interventions
Virtual Reality-Reward Training (VR-RT), Virtual Reality-Memory Training (VR-MT)
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Effect of CBT Microinterventions on Mechanisms of Behavior Change Among Adults With AUD

NCT03661853
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Control, Functional Analysis, Cognitive Restructuring, Dealing With Cravings
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 21, 2026, 3:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Taste Reward Processing in Pediatric Obesity

NCT01908153
View directory record Official record
Conditions
Pediatric Obesity
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
4 Years to 8 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Development of DBT/Parent Training Group Intervention

NCT04740138
View directory record Official record
Conditions
Parenting, Emotional Distress
Interventions
Dialectical Behavioral Therapy Skills + Parent Training
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 21, 2026, 3:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study

NCT02801643
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 45 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

Incentive-based and Media Literacy Informed Approaches to Improve Vaping Cessation

NCT05586308
View directory record Official record
Conditions
Behavior, Health Risk, Implementation Science, E Cigarette Use, Cessation, Smoking, Incentives, Engagement, Patient, Peer Support, Media Literacy
Interventions
Text-massaging suport, Financial incentive, Media literacy
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 29 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 21, 2026, 3:57 PM EDT
Not listed Not applicable Interventional

Online-Delivered Comprehensive Behavioral Intervention for Tics-Enhanced (CBIT-E)

NCT05050734
View directory record Official record
Conditions
Persistent Tic Disorders, Tourette Disorder
Interventions
Comprehensive Behavioral Intervention for Tics - Enhanced (CBIT-E)
Behavioral
Lead sponsor
Marquette University
Other
Eligibility
9 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 8, 2021 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

The Effects of Dopamine on Reward Processing

NCT01253421
View directory record Official record
Conditions
Major Depressive Disorder (MDD)
Interventions
amisulpride, placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
159 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2018 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Phase 4 Interventional Results available

Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study

NCT01748955
View directory record Official record
Conditions
Depression, Suicidal Ideation
Interventions
Paroxetine CR for Major Depressive Episode, Bupropion XL for Major Depressive Episode
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2017 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Phase 2 Interventional Results available

Cannabidiol on Reward- and Stress-related Neurocognitive Processes in Individuals With Opioid Use Disorder

NCT04982029
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Cannabidiol 100 MG/ML [Epidiolex], Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
Boston, Massachusetts • Rutland, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional Results available

Social Reward and Its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life Depression

NCT04487730
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
"Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP)
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 85 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Oct 21, 2026, 3:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neural Mechanisms for Appetitive Responses to High Reward Foods

NCT02945475
View directory record Official record
Conditions
Appetitive Behavior, Obesity
Interventions
Not listed
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 35 Years
Enrollment
114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Oct 21, 2026, 3:57 PM EDT
Completed Not applicable Interventional

Comparing Engage to PST for Late Life Depression

NCT02086201
View directory record Official record
Conditions
Major Depression
Interventions
Problem Solving Therapy, Engage
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
60 Years and older
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
White Plains, New York • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Oct 21, 2026, 3:57 PM EDT