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ClinicalTrials.gov public records Last synced Oct 21, 2026, 10:39 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 265–288 of 658 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Reward Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation

NCT02697227
View directory record Official record
Conditions
Cigarette Smoker, Tobacco Use Disorder
Interventions
Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Smoking Cessation Intervention
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Automated Reinforcement Management Systems, Phase II

NCT06456905
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Contingency Management
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 21, 2026, 10:39 PM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

The Impact of Ketamine on the Reward Circuitry of Suicidal Patients

NCT02532153
View directory record Official record
Conditions
Suicidal Ideation, Suicide
Interventions
Ketamine Hydrochloride
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 3, 2017 · Synced Oct 21, 2026, 10:39 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characterizing Psychological Consequences of Childhood Trauma

NCT00209105
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
DEX-CRF stimulation test, Psychosocial stress induction, Brain imaging of sad mood , self-reference, reward, Acoustic startle
Drug · Behavioral · Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years to 45 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 13, 2013 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Results available

Healthy Hearts Healthy Minds

NCT03373110
View directory record Official record
Conditions
Cardiovascular Diseases, Depression
Interventions
Online Mindfulness Based Cognitive Therapy, Online Cognitive Behavioral Therapy, Fitbit Alone
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 2, 2022 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Results available

Medication Adherence Patterns in Rheumatic Diseases: A Behavioral Trial

NCT04776161
View directory record Official record
Conditions
Rheumatic Diseases, Gout, Adherence, Medication, Lupus Erythematosus, Systemic
Interventions
Cue-Reward Intervention, Cue-Reward Intervention with possible intensification
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Phase 2 Interventional

Virtual Reality Intervention for Skill Acquisition Support in Autism Spectrum Disorder (ASD)

NCT05791071
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Floreo VR Building Social Connections, Sham
Device
Lead sponsor
Floreo, Inc.
Industry
Eligibility
4 Years to 10 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Thousand Oaks, California
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 21, 2026, 10:39 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Neural Mechanisms of Social Feedback Evaluation in Young Adults Across the Schizotypy Spectrum: An EEG Social Judgment Study

NCT07823621
View directory record Official record
Conditions
Schizotypy
Interventions
Social Judgment Paradigm
Behavioral
Lead sponsor
Central Connecticut State University
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2029
U.S. locations
1
States / cities
New Britain, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Phase 2 Interventional Results available

Neurobiology of Bulimia Nervosa

NCT04225221
View directory record Official record
Conditions
Bulimia Nervosa
Interventions
Estradiol, Micronized progesterone, Leuprolide Acetate, Placebo Oral Capsule
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 42 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional

Positive Affect Treatment (PAT) to Target Reward Mechanisms in Anorexia Nervosa

NCT04007900
View directory record Official record
Conditions
Anorexia Nervosa, Anorexia
Interventions
Positive Affect Treatment
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 7, 2023 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

TRUST Study of Adolescent Weight Self-Management

NCT03016247
View directory record Official record
Conditions
Adolescent Obesity
Interventions
TRUST Intervention, Enhanced Usual Care
Behavioral
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
10 Years to 12 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 2, 2019 · Synced Oct 21, 2026, 10:39 PM EDT
Recruiting Not applicable Interventional

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

NCT05973838
View directory record Official record
Conditions
Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders
Interventions
Peer-Delivered Behavioral Activation ("Peer Activate")
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland • College Park, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking Cessation Behavioral Treatment Study

NCT03948893
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Mindfulness-Oriented Recovery Enhancement (MORE), Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
2
States / cities
Columbia, Missouri • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 21, 2026, 10:39 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Multimodal Differences in Effort-based Decision-Making in Depression

NCT06648460
View directory record Official record
Conditions
Depression, Anhedonia
Interventions
Effort-based Decision-Making Task
Other
Lead sponsor
Georgia Institute of Technology
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2030
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 21, 2026, 10:39 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Nicotinic Receptor Genetic Variation and Alcohol Reward

NCT03294460
View directory record Official record
Conditions
Alcohol Drinking
Interventions
Alcohol (Oral), Alcohol (IV), Alcohol (Ethanol)
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 60 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effectiveness of Peer-to-Peer Community Support to Promote Aging in Place

NCT02308696
View directory record Official record
Conditions
Wellness Programs, Hospitalization, Emergency Room
Interventions
Peer-to-Peer Support, Standard Community Services
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
65 Years and older
Enrollment
456 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
5
States / cities
Los Angeles, California • West Palm Beach, Florida • Rochester, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2019 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Activating and Connecting Teens (ACT) Study

NCT03438656
View directory record Official record
Conditions
Depression
Interventions
Behavioral Activation
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
12 Years to 18 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Results available

Behavioral Treatment for Children With Conduct Problems and Callous-Unemotional Traits

NCT01362946
View directory record Official record
Conditions
Conduct Disorder, Oppositional Defiant Disorder
Interventions
Reward-Emphasized Treatment, Standard Treatment
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
7 Years to 12 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 15, 2016 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional

GODART Pilot and Feasibility

NCT05344859
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
Weekly Automated Health Coaching, Weekly Human Health Coaching, Adapted Reward Level, Fixed Gamified Reward Level
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 21, 2026, 10:39 PM EDT
Recruiting Not applicable Interventional

Understanding Motivation in Parkinson's Patients Through Neurophysiology

NCT05065151
View directory record Official record
Conditions
Parkinson Disease, Deep Brain Stimulation, Motivation
Interventions
Stimulation on, Stimulation off, Decision Making Task
Other · Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional

EEG Biofeedback to Improve Memory in Adults With Dementia

NCT01168466
View directory record Official record
Conditions
Dementia
Interventions
QEEG-based Neurofeedback Training
Behavioral
Lead sponsor
Quietmind Foundation
Other
Eligibility
45 Years to 85 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Lafayette Hill, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Oct 21, 2026, 10:39 PM EDT
Not listed Not applicable Interventional

Peer Professionals to Increase Capacity to Treat ADHD

NCT04238403
View directory record Official record
Conditions
Attention Deficit and Disruptive Behavior Disorders
Interventions
Behavioral Parent Training (MATCH Protocol)
Behavioral
Lead sponsor
New York University
Other
Eligibility
Up to 99 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2020 · Synced Oct 21, 2026, 10:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility & Characterization of Project: EVO Monitor Cognitive Measurements

NCT02792296
View directory record Official record
Conditions
Healthy
Interventions
Project: EVO Monitor
Other
Lead sponsor
Akili Interactive Labs, Inc.
Industry
Eligibility
40 Years to 55 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Little Rock, Arkansas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Oct 21, 2026, 10:39 PM EDT
Recruiting Not applicable Interventional

Neuroimaging of Adolescent Cannabis Use Treatment

NCT07340554
View directory record Official record
Conditions
Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse, Cannabis Intoxication, Cannabis Smoking, Cannabis Withdrawal, Cannabis-Related Disorder, Cannabis Abuse, in Remission, Cannabis Abuse, Episodic Use, Marijuana, Marijuana Abuse, Marijuana Use, Marijuana Smoking, Marijuana Dependence, Marijuana User, Marijuana-Related Disorder, Marijuana Use Disorder, Addiction, Addiction, Substance, Substance Use, Substance Use Disorders, Substance Dependence, Substance Abuse, Substance Related Problem, Substance Abuse Drug Chronic
Interventions
Contingency Management, Elastic Net Regression
Behavioral · Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 21, 2026, 10:39 PM EDT