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ClinicalTrials.gov public records Last synced Oct 21, 2026, 5:53 AM EDT

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Showing 97–120 of 658 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Reward Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Caregiver Stress and Sleep Study

NCT05219955
View directory record Official record
Conditions
Depressive Symptoms, Caregiver Burden
Interventions
Morning Action Plan Execution, Activity Strategy-based Session with Therapist, Attention-based Session with Therapist, Advance sleep-wake time
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
55 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Results available

Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia

NCT05084924
View directory record Official record
Conditions
Major Depressive Disorder, Anhedonia
Interventions
Cross-frequency transcranial alternating current stimulation via the NeuroConn Direct Current Stimulator Plus
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Process and Outcomes in CBT for Anxious and Depressed Youth

NCT03100279
View directory record Official record
Conditions
Anxiety Disorders, Depression
Interventions
Coping Cat/CAT Project, Primary and Secondary Coping Enhancement Therapy
Behavioral
Lead sponsor
Rutgers University
Other
Eligibility
7 Years to 17 Years
Enrollment
247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2020
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Phase 2 Interventional Results available

Neurobiology of Bulimia Nervosa

NCT04225221
View directory record Official record
Conditions
Bulimia Nervosa
Interventions
Estradiol, Micronized progesterone, Leuprolide Acetate, Placebo Oral Capsule
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 42 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Impact of Cannabis Use and Abstinence on Emotion

NCT07746440
View directory record Official record
Conditions
Cannabis Use Disorder, Severe
Interventions
Contingency management for cannabis abstinence and lab visit attendance, Contingency management for lab visit attendance
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 30 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant

NCT05203965
View directory record Official record
Conditions
Familial Alcoholism Vulnerability
Interventions
Mavoglurant (AFQ056), Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional

Intervention Effects of Intensity and Delivery Style for Toddlers With Autism

NCT02272192
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Early Start Denver Model (ESDM), Early Intensive Behavioral Intervention (EIBI)
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
15 Months to 30 Months
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
3
States / cities
Sacramento, California • Nashville, Tennessee • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

We The Village Family Support Study

NCT04250077
View directory record Official record
Conditions
Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
Interventions
Community Reinforcement And Family Training (CRAFT), We The Village Peer Community Forum
Behavioral
Lead sponsor
We The Village, Inc.
Other
Eligibility
19 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of D-amphetamine on Reward Functioning

NCT03369015
View directory record Official record
Conditions
Anhedonia
Interventions
10 mg d-amphetamine, 20mg d-amphetamine, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 35 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 5, 2020 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Results available

Reaching and Engaging Depressed Senior Center Clients (REDS)

NCT03246789
View directory record Official record
Conditions
Depression, Unipolar, Mental Health Disorder
Interventions
Engage-M, Wellness in Mind and Body
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
55 Years to 100 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Oct 21, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional

Examining the Effectiveness of the Early Start Denver Model in Community Programs Serving Young Autism

NCT06005285
View directory record Official record
Conditions
Autism
Interventions
Early Start Denver Model (ESDM), Early Intensive Behavioral Intervention (EIBI)
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
12 Months and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Results available

Reaching and Engaging Depressed Senior Center Clients

NCT04289298
View directory record Official record
Conditions
Depression in Old Age
Interventions
Engage-A, Training and utilizing Engage-A therapy
Behavioral · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
55 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Results available

Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement

NCT02805309
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Exercise, Cognitive behavioral interventions, Attention control education program
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Physical Activity Smartphone App for African American Men (FitBros) Ph II

NCT05621044
View directory record Official record
Conditions
Exercise, Health Behavior, Technology
Interventions
FitBrothers smartphone active app, Nike Training Club
Behavioral
Lead sponsor
Klein Buendel, Inc.
Industry
Eligibility
30 Years and older · Male only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
3
States / cities
Golden, Colorado • Washington D.C., District of Columbia • Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Behavioral and Neural Representations of Subjective Effort Cost

NCT04041154
View directory record Official record
Conditions
Fatigue
Interventions
Cognitive Fatigue, Physical Fatigue, Rewarding Stimuli
Behavioral
Lead sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Other
Eligibility
18 Years to 35 Years
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Recruiting Not applicable Interventional

FlexED: National Substudy

NCT07807774
View directory record Official record
Conditions
Eating Disorders, Body Image
Interventions
FlexED
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 25 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

An Investigation of Early Life Stress and Depression

NCT01701258
View directory record Official record
Conditions
Major Depressive Disorder (MDD), History of Childhood Sexual Abuse (CSA)
Interventions
Amisulpride, Placebo
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
20 Years to 45 Years · Female only
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
Belmont, Massachusetts • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Decision Making, Daily Experiences, and Brain Activity in Young Adult Women

NCT04125589
View directory record Official record
Conditions
Binge-Eating Disorder
Interventions
Speaking Activity, Talking Activity
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Behavioral Therapy With Parental Involvement for Treating Children With Anxiety Disorders

NCT00620958
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Individual cognitive behavioral therapy (ICBT), Parent relationship training (PRT2) With Individual Cognitive Behavioral Therapy (ICBT), Parent reinforcement training (PRT1) With Individual Cognitive Behavioral Therapy (ICBT)
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
8 Years to 11 Years
Enrollment
341 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 2, 2017 · Synced Oct 21, 2026, 5:53 AM EDT
Withdrawn No phase listed Observational

REWARDS- In-stent Restenosis

NCT03008772
View directory record Official record
Conditions
In-Stent Coronary Artery Restenosis
Interventions
Not listed
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Inflammation in Methamphetamine and STIs (IMSTI)

NCT05162391
View directory record Official record
Conditions
Methamphetamine-dependence, Rectal Gonorrhea, Rectal Chlamydia
Interventions
Contingency Management
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Male only
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 21, 2026, 5:53 AM EDT
Completed No phase listed Observational

Neural Substrates of Approach-Avoidance Conflict

NCT02119624
View directory record Official record
Conditions
Alcoholism, fMRI, Rewarding Mediating System
Interventions
Not listed
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
21 Years to 60 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Oct 21, 2026, 5:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility & Characterization of Project: EVO Monitor Cognitive Measurements

NCT02792296
View directory record Official record
Conditions
Healthy
Interventions
Project: EVO Monitor
Other
Lead sponsor
Akili Interactive Labs, Inc.
Industry
Eligibility
40 Years to 55 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Little Rock, Arkansas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Oct 21, 2026, 5:53 AM EDT
Enrolling by invitation Not applicable Interventional

Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression

NCT07467473
View directory record Official record
Conditions
Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst
Interventions
Accelerated Intermittent Theta Burst Transcranial Magnetic Stimulation
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 21, 2026, 5:53 AM EDT