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Conditions: Neonatal Screening, Kernicterus, Newborn Jaundice, Point-of-Care Testing
Interventions: Bilistick System 2.0 point-of-care testing device; Diagnostic Test
Lead sponsor: Kettering Health Network; Other
Eligibility: Up to 2 Weeks
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Kettering, Ohio

Conditions: Eustachian Tube Dysfunction, Laryngopharyngeal Reflux
Interventions: Omeprazole, Ranitidine, Pantoprazole, 24-Hour Diagnostic pH-Probe Test, Laryngoscopy; Drug · Procedure
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 2
States / cities: Loma Linda, California • Redlands, California

Conditions: Chronic Low Back Pain (CLBP)
Interventions: Empowering Pain Psychology Access and Collaboration (EPPAC), Usual Care Pain Psychology Evaluation; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Osteoarthritis, Knee
Interventions: AposHealth, Total Knee Replacement (TKR); Device · Procedure
Lead sponsor: Geisinger Clinic; Other
Eligibility: 45 Years to 80 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Danville, Pennsylvania • Wilkes-Barre, Pennsylvania

Conditions: Human Immunodeficiency Virus, Smoking Cessation, Smoking, Cigarette, Smoking, Anxiety, Depression, Nicotine Dependence
Interventions: QUIT, Time-Matched Control (TM); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 79 Years
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 3
States / cities: Boston, Massachusetts • Houston, Texas

Conditions: Aging, Functional Recovery, Skilled Nursing Facility, Medically Complex, Deconditioning
Interventions: i-STRONGER, Usual Care; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 50 Years to 120 Years
Enrollment: 4,383 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: Aurora, Colorado • Frisco, Texas

Conditions: Glioblastoma, IDH-Wildtype, MGMT-Unmethylated Glioblastoma
Interventions: Biospecimen Collection, Magnetic Resonance Imaging, Radiation Therapy, STAT3 Inhibitor WP1066, Surgical Procedure; Procedure · Radiation · Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Chicago, Illinois • Warrenville, Illinois

Conditions: Total Knee Arthroplasty, Functional Recovery, Aging, Physical Therapy
Interventions: NMES, Usual Care; Procedure · Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 3,250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 3
States / cities: Aurora, Colorado • Murray, Utah

Conditions: Acute Myocardial Infarction
Interventions: Post Conditioning + Primary PCI, Standard Primary PCI; Procedure
Lead sponsor: Minneapolis Heart Institute Foundation; Other
Eligibility: 18 Years to 80 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Brain Concussion
Interventions: Concussion; Other
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 10 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Lymphoma, Sarcoma
Interventions: Electrocardiogram, Echocardiogram, LVEF echocardiogram, Apple Watch, Biospecimen collection, Questionnaires, Cardio-pulmonary exercise test, 6 minute walk test, Grip strength test; Procedure · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer
Interventions: omega-3 fatty acid supplement, Placebo, Clinical assessments, Assessment of therapy complications, Magnetic Resonance Imaging, Correlative/special studies; Dietary Supplement · Other · Procedure
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Small Cell Cancer Of The Lung, Small Cell Lung Cancer ( SCLC ), Lung Cancer, Small-Cell Lung Cancer (SCLC)
Interventions: Biospecimen collection; Procedure
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Delivery of Health Care, Genetic Testing, Humans, Pregnancy, Noninvasive Prenatal Testing, Informed Consent, Internet-Based Intervention, Self Efficacy, Pregnant People, Decision Making, Health Education, Patient Education as Topic/Method
Interventions: Mobile-based Educational Intervention; Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 1,400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 3
States / cities: San Francisco, California • Jacksonville, Florida • Chapel Hill, North Carolina

Conditions: Acquired Hemophilia A
Interventions: OBIZUR; Biological
Lead sponsor: Baxalta now part of Shire; Industry
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 6
States / cities: Gainesville, Florida • Detroit, Michigan • Durham, North Carolina + 2 more

Conditions: Diabetes Mellitus, Type 1
Interventions: Usual care, Collaborative care model (CoCM); Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Glioblastoma, Glial Tumor, Brain Metastases, Meningioma, Schwannoma, Pituitary Tumor
Interventions: CONVIVO system, Conventional histologic evaluation; Diagnostic Test · Other
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Squamous Cell Carcinoma
Interventions: Standard surveillance, Telemedicine surveillance (tele-surveillance), Questionnaires; Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Heart Decompensation, Acute, Acute Kidney Injuries
Interventions: Furosemide (Standard Diuretic) Treatment, POCUS-Assessed Diuretic Management; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 588 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 5
States / cities: Pittsburgh, Pennsylvania

Conditions: Gait, Unsteady, Vestibular Disorder
Interventions: OKS; Device
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 50 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Asthma
Interventions: Mepolizumab, Spirometry; Drug · Other
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years and older
Enrollment: 336 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 28
States / cities: La Jolla, California • Newport Beach, California • Aurora, Colorado + 24 more

Conditions: Cervical Cancer
Interventions: Questionnaires, Biological Samples; Behavioral · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 285 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Obtain Diagnostic Images With the New Digital Camera and Image Processor for Evaluation.
Interventions: Radiography and Fluoroscopy Imaging System; Device
Lead sponsor: Toshiba America Medical Systems, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Drug Related Side Effects and Adverse Reactions, Infusion Reactions
Interventions: PIV-850 (850-picometer Dual-NCE Acidic Matrix), Legacy Heterogeneous Payload (Micellar Vehicle); Drug
Lead sponsor: PICO IV, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 625 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Sacramento, California

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Bilistick Point-of-care System 2.0 Bilirubin Validation

The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux

Empowering Pain Psychology Access and Collaboration (EPPAC) to Improve Treatment Engagement Among Medicaid-insured Adults With Chronic Low Back Pain

Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement

Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV

Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities

WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

Phase II Clinical Trial to Evaluate the Benefits of Postconditioning in ST-Elevation Myocardial Infarction (STEMI)

Tissue Repository and Master Database for Concussion Biomarker and Risk Calculator Development

WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring)

Omega-3 Fatty Acids in Preventing Joint Symptoms in Patients With Stage I-III Breast Cancer Receiving Anastrozole, Exemestane, or Letrozole

Prospective Multiomic Analysis in Small-Cell Lung Cancer

Supporting Just-In-Time Consent for Prenatal Screening: The INFORM Study

Prospective and Retrospective, Non-interventional Study to Evaluate the Safety and Effectiveness of Obizur in Real-life Practice

Testing an Integrated Care Model Trial

Evaluation of the CONVIVO System

Comparing Two Surveillance Approaches for People Who Have Received Treatment for HPV-associated Head and Neck Cancer and Show No Signs of Disease

POCUS-Guided Diuresis for Decompensated Heart Failure

OKS for Gait Instability

REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study

Community Awareness, Resources and Education (CARE II) Project: Project 1

Clinical Image Evaluation for the DREX-KL80 Imaging System

Retrospective Kinetic Safety Evaluation of an Intravenous Micellar Excipient Platform