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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:17 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: S-Adenosylmethionine (SAMe) Clear all

Conditions: HIV-1 Infection
Interventions: Zinc and SAMe; Dietary Supplement
Lead sponsor: Emory University; Other
Eligibility: 21 Years and older
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Alcoholic Cirrhosis
Interventions: Placebo, SAMe 400 mg tablet; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 196 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2027
U.S. locations: 2
States / cities: Los Angeles, California • Indianapolis, Indiana

Conditions: Osteoarthritis Hand
Interventions: S-Adenosyl-L-Methionine (Sam-E), Placebo; Drug
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 40 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Stroke
Interventions: FAST alone, FAST+SAM, SAM alone; Behavioral
Lead sponsor: University of Delaware; Other
Eligibility: 21 Years to 85 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Heart Disease
Interventions: SAMe, Placebo; Dietary Supplement · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Tobacco Dependence
Interventions: S-Adenosyl-L-Methionine, placebo; Drug · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Rochester, Minnesota • La Crosse, Wisconsin

Conditions: Alzheimer's Disease, Mild Cognitive Impairment
Interventions: Nutriceutical formulation, Placebo; Dietary Supplement · Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 40 Years and older
Enrollment: 135 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 8
States / cities: Naples, Florida • Baltimore, Maryland • Ayer, Massachusetts + 5 more

Conditions: Juvenile Idiopathic Arthritis
Interventions: CP-690,550 (tofacitinib), placebo; Drug · Other
Lead sponsor: Pfizer; Industry
Eligibility: 2 Years to 17 Years
Enrollment: 225 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 55
States / cities: Little Rock, Arkansas • Loma Linda, California • Los Angeles, California + 24 more

Conditions: Solid Cancer
Interventions: Poly-ICLC combination treatment with aPD-1 (Nivolumab or Pembrolizumab) or aPD-L1 (Atezolizumab or Durvalumab) over 6 months; Biological
Lead sponsor: Oncovir, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 3
States / cities: Chevy Chase, Maryland • Easton, Maryland • New York, New York

Conditions: Abdominal Pain
Interventions: S-adenosyl methionine; Drug
Lead sponsor: Huang, Jeannie, M.D.; Individual
Eligibility: 8 Years to 22 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: San Diego, California

Conditions: Colorectal Cancer (Diagnosis), Adenoma
Interventions: S-Adenosylmethionine (SAMe); Drug
Lead sponsor: Jun Gong, MD; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Use
Interventions: Standard intervention (counseling + self-help written materials), Enhanced Intervention (same as standard treatment plus 10-15 min of counseling and a culturally tailored video); Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older · Female only
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Sleep Disturbance
Interventions: S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate; Dietary Supplement
Lead sponsor: Bonafide Health; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Harrison, New York

Conditions: Depression
Interventions: S-adenosyl methione (SAMe), Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 80 Years
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mild Cognitive Impairment, Metabolic Syndrome
Interventions: Dietary intervention; Behavioral
Lead sponsor: Bristlecone Health, Inc.; Industry
Eligibility: 35 Years to 80 Years
Enrollment: 98 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Maple Grove, Minnesota

Conditions: Liver Cirrhosis, Biliary
Interventions: S-adenosyl-methionine (SAMe) capsules; Drug
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 21 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Mild Cognitive Impairment
Interventions: Memory XL, placebo; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 55 Years to 85 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 2
States / cities: Oklahoma City, Oklahoma

Conditions: Bipolar Disorder, Depression, Bipolar Depression
Interventions: SAMe, Placebo; Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Hyperhomocysteinemia
Interventions: S-adenosylmethionine; Dietary Supplement
Lead sponsor: Baylor Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Parkinson's Disease, Depression
Interventions: SAM-e, oral escitalopram, placebo; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 30 Years to 80 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcoholic Hepatitis
Interventions: Placebo, SAMe; Other · Dietary Supplement
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Hepatitis
Interventions: S-adenosylmethionine; Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older · Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: HIV
Interventions: Zinc and SAMe; Dietary Supplement
Lead sponsor: Emory University; Other
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 2
States / cities: Atlanta, Georgia • Decatur, Georgia

Conditions: Adenocarcinoma of the Prostate
Interventions: Muscadine Plus, Placebos; Drug
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Other
Eligibility: 18 Years to 99 Years · Male only
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 13
States / cities: Duarte, California • La Jolla, California • Aurora, Colorado + 10 more

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Researching Alveolar Macrophage Improvements With Supplements in HIV

SAMe Trial for Patients With Alcoholic Cirrhosis

S-Asenosyl-L-Methionine vs Placebo for Osteoarthritis of the Hands

Promoting Recovery Optimization With WALKing Exercise After Stroke

Effect of the Dietary Supplement SAMe on Blood Homocysteine Levels

S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence

A Clinical Trial of a Vitamin/Nutriceutical Formulation for Alzheimer's Disease

Efficacy Study Of Tofacitinib In Pediatric JIA Population

Poly-ICLC (Hiltonol) and Anti-PD1 or Anti-PD-L1

Evaluation of S-adenosyl Methionine (SAM-e) for Recurrent Abdominal Pain in Children

S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas

Tobacco Cessation Treatment for Pregnant Alaska Natives

Bonafide Sleep Supplement for Menopausal Women With Sleep Complaints

Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression

Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation

SAMe to Treat Biliary Cirrhosis Symptoms

MemoryXL Effects on Mild Cognitive Impairment Patients

A Trial of SAMe for Treatment-Resistant Bipolar Depression

Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine

SAM-e for the Treatment of Depression in Patients With Parkinson's Disease

Randomized, Controlled Trial of S-adenosylmethionine in Alcoholic Liver Disease

S-Adenosylmethionine Therapy for Non-Alcoholic Steatohepatitis

Immune Enhancement for Immunological Non-responders to ART

Muscadine Plus (MPX) In Men With Prostate Cancer