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Showing 1–24 of 70 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: SMI Clear all
Withdrawn Phase 2 Interventional

Olanzapine in OUD Patients

NCT05179772
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Olanzapine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional Results available

A Transdiagnostic Sleep and Circadian Treatment to Improve Community SMI Outcomes

NCT02469233
View directory record Official record
Conditions
Mental Disorders
Interventions
Transdiagnostic Intervention for Sleep and Circadian Dysfunction
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Sep 10, 2026, 4:22 AM EDT
Recruiting Not applicable Interventional

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

NCT05815199
View directory record Official record
Conditions
Cigarette Smoking
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional Results available

Improving Outcomes for Individuals With Serious Mental Illness and Diabetes

NCT01410357
View directory record Official record
Conditions
Diabetes Mellitus, Bipolar Disorder, Depression, Psychotic Disorders, Schizophrenia
Interventions
Targeted Training in Illness Management (TTIM)
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 3, 2017 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Development of a Mobile Heath Augmented Brief Suicide Prevention Intervention for People With SMI

NCT03198364
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Suicide and Self-harm
Interventions
Safety and Recovery Therapy, Mobile Augmentation
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional Results available

Mental Health Services for Prisoners With SMI

NCT03713398
View directory record Official record
Conditions
Mental Disorder
Interventions
T4C-SMI
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Sep 10, 2026, 4:22 AM EDT
Enrolling by invitation Not applicable Interventional

Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness

NCT05703412
View directory record Official record
Conditions
Bipolar Disorder, Major Depression, Schizophrenia
Interventions
Transition-FOCUS mHealth Intervention, Check-In
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Sep 10, 2026, 4:22 AM EDT
Withdrawn Not applicable Interventional

Lifestyle MIND- Feasibility of Wait-list Control

NCT06384521
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Serious Mental Illness, Schizophrenia, Major Depression, Bipolar Disorder
Interventions
Lifestyle MIND
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Self-Management Training and Automated Telehealth to Improve SMI Health Outcomes

NCT02188732
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depression
Interventions
CBHH+AT, CBHH+SMT, CBHH
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Evaluation of the In SHAPE Fitness Intervention for Adults With Serious Mental Illness

NCT02334228
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Schizoaffective Disorder, Major Depressive Disorder
Interventions
In SHAPE Lifestyles, Health Club Membership and Education
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Concord, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 7, 2015 · Synced Sep 10, 2026, 4:22 AM EDT
Not listed Not applicable Interventional

Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)

NCT04321759
View directory record Official record
Conditions
Schizophrenia and Related Disorders
Interventions
Cognitive Enhancement Therapy, Social Skills Training
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
378 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
5
States / cities
Hartford, Connecticut • Portland, Maine • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2023 · Synced Sep 10, 2026, 4:22 AM EDT
Recruiting Not applicable Interventional

Abriendo Caminos: Engaging Latinos

NCT07529509
View directory record Official record
Conditions
Serious Mental Illness
Interventions
Culturally responsive motivational interviewing
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional Results available

Testing Effectiveness of a Peer-Led Intervention to Enhance Community Integration

NCT02508480
View directory record Official record
Conditions
Mental Disorders
Interventions
Photovoice, Enhanced Control
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Treatment of Post Traumatic Stress Disorder in Patients With Other Mental Illnesses

NCT00053690
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Cognitive Behavior Treatment
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Claremont, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 9, 2013 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Phase 3 Interventional

HIV Prevention Among Substance Abusing SMI

NCT00447720
View directory record Official record
Conditions
Mentally Ill Persons, Substance Abuse, HIV Infections
Interventions
PATH
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional Results available

Impact of VVV Group for Veterans With SMI

NCT05562674
View directory record Official record
Conditions
Psychotic Disorders, Veterans
Interventions
Veteran Voices and Visions
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional Results available

Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness

NCT02845440
View directory record Official record
Conditions
Cigarette Smoking, Schizophrenia, Bipolar Disorder, Depressive Disorder, Major, Smoking Cessation
Interventions
Academic Detailing, Community Health Worker, Treatment as Usual (TAU)
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
1,165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 18, 2022 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional Results available

PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness)

NCT01542229
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
Interventions
Prolonged Exposure for PTSD (PE) + Treatment as Usual (TAU), Treatment As Usual (TAU)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 14, 2019 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Creating Welcoming Faith Communities for People With Serious Mental Illnesses

NCT06336980
View directory record Official record
Conditions
Other
Interventions
Increasing Inclusionary Practices in Faith Communities
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI

NCT02334280
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
Interventions
In SHAPE
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
4
States / cities
Lebanon, New Hampshire • Manchester, New Hampshire • Nashua, New Hampshire + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2015 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional

An Integrated Approach to Smoking Cessation in Severe Mental Illness (SMI)

NCT00690131
View directory record Official record
Conditions
Smoking Cessation
Interventions
BTSCS
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 75 Years
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
3
States / cities
Baltimore, Maryland • Timonium, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2020 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Phase 4 Interventional

Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)

NCT00453609
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Alcohol Dependence
Interventions
long-lasting injectable naltrexone
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 69 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
3
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Dec 10, 2008 · Synced Sep 10, 2026, 4:22 AM EDT
Not listed Not applicable Interventional

Peer Wellness Enhancement For Patients With Serious Mental Illness and High Medical Costs

NCT03673852
View directory record Official record
Conditions
Chronic Medical Condition
Interventions
WE Harambee, Behavioral Health Home Enrollment
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 16, 2022 · Synced Sep 10, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Social Media Alcohol Intervention

NCT02809586
View directory record Official record
Conditions
Drinking Behavior, Risky Drinking
Interventions
SMI + I, SMI
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
16 Years to 24 Years
Enrollment
955 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 4, 2024 · Synced Sep 10, 2026, 4:22 AM EDT