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ClinicalTrials.gov public records Last synced Oct 28, 2026, 5:39 AM EDT

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Showing 49–71 of 71 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: SMI Clear all
Recruiting Not applicable Interventional

MI-CBTech: A Mobile Intervention for Community Integration in Homeless-Experienced Veterans With SMI

NCT06138054
View directory record Official record
Conditions
Schizophrenia Spectrum Disorders, Psychotic Affective Disorders, Psychotic Mood Disorders, Homelessness, Ill-Housed Persons
Interventions
MI-CBTech, Mindfulness control
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional

Interactive Obesity Treatment Approach (iOTA) for Obesity Prevention in Serious Mental Illness

NCT03695289
View directory record Official record
Conditions
Obesity, Mentally Ill Persons
Interventions
iOTA SMI, Health Education Control
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 16, 2020 · Synced Oct 28, 2026, 5:39 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Impairments That Affect Correct Inhaler Use in COPD

NCT06135324
View directory record Official record
Conditions
COPD
Interventions
Not listed
Lead sponsor
COPD Foundation
Other
Eligibility
60 Years to 90 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
9
States / cities
Birmingham, Alabama • Chicago, Illinois • Burlington, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated May 11, 2025 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental Disabilities in Congregate Living Settings

NCT04726371
View directory record Official record
Conditions
Intellectual Disability, Developmental Disability, Axis I Diagnosis, Mental Illness, Covid19, Coronavirus
Interventions
Generic Best Practices, Tailored Best Practices
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
415 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional

Family Intervention for Mental Illness and Substance Abuse

NCT00043693
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Substance-related Disorders
Interventions
Family Intervention for Dual Diagnosis, Family psychoeducation program
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
2
States / cities
Santa Fe Springs, California • Chelsea, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 8, 2012 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional Results available

Testing Effectiveness of a Peer-Led Intervention to Enhance Community Integration

NCT02508480
View directory record Official record
Conditions
Mental Disorders
Interventions
Photovoice, Enhanced Control
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 10, 2020 · Synced Oct 28, 2026, 5:39 AM EDT
Recruiting Not applicable Interventional

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

NCT05815199
View directory record Official record
Conditions
Cigarette Smoking
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional

Helping Veterans With SMI "StayQuit" From Smoking After Inpatient Hospitalization

NCT03367520
View directory record Official record
Conditions
StayQuit Intervention
Interventions
StayQuit
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Phase 1 Interventional

Individually Based Psychosocial Rehabilitation for Older People With Serious Mental Illness (SMI)

NCT00817154
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
Interventions
HOPES-I
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
50 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Concord, New Hampshire • Nashua, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 7, 2014 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Smoking Cessation for Veterans With Severe and Persistent Mental Illness

NCT00960375
View directory record Official record
Conditions
Schizoaffective Disorder, Schizophrenia, Affective Psychosis, Bipolar, Affective Disorders, Psychotic
Interventions
BTSCS, StSST
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 75 Years
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 18, 2015 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional Results available

Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI)

NCT03873337
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Tobacco Use Disorder, Schizophrenia, Schizoaffective Disorder
Interventions
Persistence Targeted Smoking Cessation in SMI (PTSC-S), Nicotine patch
Behavioral · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 70 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Get Moving and Get Well - Pilot Study

NCT01884025
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression, Post Traumatic Stress Disorder
Interventions
Get Moving and Get Well, Health and Humor Class
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
North Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Nov 5, 2018 · Synced Oct 28, 2026, 5:39 AM EDT
Not yet recruiting Not applicable Interventional

Supporting Older Adults Remotely

NCT07878169
View directory record Official record
Conditions
Severe Mental Illness
Interventions
Supporting Older Adults Remotely (SOAR), Peer support as usual
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2026 · Synced Oct 28, 2026, 5:39 AM EDT
Not listed Not applicable Interventional

Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)

NCT04321759
View directory record Official record
Conditions
Schizophrenia and Related Disorders
Interventions
Cognitive Enhancement Therapy, Social Skills Training
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
378 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
5
States / cities
Hartford, Connecticut • Portland, Maine • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2023 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety Comparison of Tiotropium Inhalation Solution (Respimat Inhaler) and Spiriva HandiHaler in COPD

NCT00239447
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
Tiotropium, HandiHaler, Respimat SMI
Drug · Device
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
40 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
10
States / cities
Little Rock, Arkansas • San Diego, California • San Jose, California + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 1, 2023 · Synced Oct 28, 2026, 5:39 AM EDT
Enrolling by invitation Not applicable Interventional

Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness

NCT05703412
View directory record Official record
Conditions
Bipolar Disorder, Major Depression, Schizophrenia
Interventions
Transition-FOCUS mHealth Intervention, Check-In
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 28, 2026, 5:39 AM EDT
Not listed Not applicable Interventional

Peer Wellness Enhancement For Patients With Serious Mental Illness and High Medical Costs

NCT03673852
View directory record Official record
Conditions
Chronic Medical Condition
Interventions
WE Harambee, Behavioral Health Home Enrollment
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 17, 2022 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional Results available

PACT for Individuals With Serious Mental Illness

NCT01668355
View directory record Official record
Conditions
Schizophrenia Spectrum & Other Psychotic Disorders
Interventions
Patient Aligned Care Team (PACT)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
3
States / cities
San Diego, California • West Los Angeles, California • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Feb 28, 2020 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Phase 3 Interventional

HIV Prevention Among Substance Abusing SMI

NCT00447720
View directory record Official record
Conditions
Mentally Ill Persons, Substance Abuse, HIV Infections
Interventions
PATH
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Phase 2 Interventional

Cognitive Behavioral Therapy for Post-Traumatic Stress Disorder in Individuals With Severe Mental Illness

NCT00078741
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Schizophrenia
Interventions
Cognitive Behavioral Therapy (CBT)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
2
States / cities
Charleston, South Carolina • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 10, 2015 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional

Health Promotion and Fitness for Younger and Older Adults With SMI

NCT02090335
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
Interventions
In SHAPE, Fitness Club Membership
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
3
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 18, 2014 · Synced Oct 28, 2026, 5:39 AM EDT
Completed Not applicable Interventional

Evaluating the Use of Peer Specialists to Deliver Cognitive Behavioral Social Skills Training

NCT03467243
View directory record Official record
Conditions
Serious Mental Illness
Interventions
Cognitive Behavioral Social Skills Training, Social Skills Training, Treatment as usual
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 28, 2026, 5:39 AM EDT
Recruiting Not applicable Interventional

Facilitation to Increase Tobacco Treatment

NCT07455526
View directory record Official record
Conditions
Serious Mental Illness, Tobacco Use Disorder
Interventions
Multi-component facilitation
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 28, 2026, 5:39 AM EDT