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ClinicalTrials.gov public records Last synced Sep 29, 2026, 2:57 AM EDT

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Showing 1–18 of 18 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Scaling and Root Planing (SRP) Clear all
Active, not recruiting No phase listed Observational

Effectiveness of Scaling and Root Planing in Deeper Pockets

NCT06890689
View directory record Official record
Conditions
Periodontal Disease, Periodontitis
Interventions
Scaling and root planing
Procedure
Lead sponsor
Texas A&M University
Other
Eligibility
Not listed
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 29, 2026, 2:57 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Novel Dental Gel as an Adjunct to Scaling and Root Planing

NCT05384132
View directory record Official record
Conditions
Periodontal Diseases, Gingival Diseases, Gingival Pocket, Gum Bleed, Plaque, Dental
Interventions
SRP + Livfresh Dental Gel, SRP + standard flouride dentifrice
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 85 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Phase 2 Interventional

Trial to Evaluate Safety, Tolerability, Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis

NCT04093895
View directory record Official record
Conditions
Periodontitis
Interventions
PerioSept(r)
Drug
Lead sponsor
Geistlich Pharma AG
Industry
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Not applicable Interventional

Periodontitis and Cardiovascular Events or "PAVE"

NCT00066053
View directory record Official record
Conditions
Cardiovascular Disease, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Accident
Interventions
Periodontal Treatment: SRP, Referral
Procedure
Lead sponsor
University at Buffalo
Other
Eligibility
Up to 75 Years
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2011 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg

NCT03762915
View directory record Official record
Conditions
SRP, Minocycline HCl Microspheres, Biomarkers
Interventions
minocycline HCl microspheres
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Phase 3 Interventional Results available

Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis

NCT00529555
View directory record Official record
Conditions
Adult Periodontitis
Interventions
minocycline HCl 2.1%, Scaling and root planing
Drug · Procedure
Lead sponsor
Sunstar Americas
Industry
Eligibility
18 Years and older
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
10
States / cities
Birmingham, Alabama • San Francisco, California • Gainsville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated May 8, 2014 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Phase 2 Interventional Results available

Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

NCT00066066
View directory record Official record
Conditions
Periodontitis, Periodontal Diseases
Interventions
Scaling and root planing, Metronidazole, Amoxicillin, Doxycycline
Procedure · Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
20 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 21, 2013 · Synced Sep 29, 2026, 2:57 AM EDT
Recruiting Not applicable Interventional

A Clinical Trial Comparing 2x/Day for 30-minutes Use of the Emanate Perio PODS Post-SRP to a Control Group Post-SRP.

NCT06914596
View directory record Official record
Conditions
Periodontitis (Stage 3)
Interventions
Emanate Perio PODS
Device
Lead sponsor
McGuire Institute
Industry
Eligibility
30 Years to 75 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
8
States / cities
Fullerton, California • New London, Connecticut • Boston, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

A Phase I/II Study to Evaluate the Safety and Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis

NCT02313883
View directory record Official record
Conditions
Periodontitis
Interventions
PerioSept(r)
Drug
Lead sponsor
Geistlich Pharma AG
Industry
Eligibility
18 Years to 74 Years
Enrollment
127 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
4
States / cities
Fullerton, California • Ann Arbor, Michigan • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2019 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Phase 2 Interventional

Microbial Associations in Periodontal Health and Disease

NCT00066001
View directory record Official record
Conditions
Periodontitis, Periodontal Diseases
Interventions
metronidazole
Drug
Lead sponsor
The Forsyth Institute
Other
Eligibility
35 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 8, 2010 · Synced Sep 29, 2026, 2:57 AM EDT
Recruiting Early Phase 1 Interventional

Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics

NCT07298057
View directory record Official record
Conditions
Periodontitis, Diabetes Mellitus Type 2
Interventions
local antibiotic application of topical minocycline, Scaling and Root Planing
Drug · Procedure
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Phase 2 Interventional Results available

Impact of Periodontal Therapy on Patients With Diabetes

NCT04830969
View directory record Official record
Conditions
Diabetes Mellitus, Type II, Periodontitis
Interventions
Chlorhexidine gluconate oral rinse, Scaling & Root Planing, Soft Picks
Drug · Procedure · Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
25 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Phase 4 Interventional Results available

Baseline Oral Health Study: UnCoVer the Connections to General Health

NCT04954313
View directory record Official record
Conditions
Cardiovascular Diseases, Diabetes Type 2
Interventions
Subgingival chlorhexidine irrigation, Dental Supplies, Periodonal Treatment
Drug · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
786 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Not applicable Interventional

Periodontal Infection and Systemic Inflammation in Renal Patients

NCT01094639
View directory record Official record
Conditions
Periodontitis, Chronic Kidney Disease
Interventions
Scaling root planing, Supragingival Prophylaxis
Procedure
Lead sponsor
UConn Health
Other
Eligibility
21 Years to 85 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 24, 2016 · Synced Sep 29, 2026, 2:57 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities

NCT05422742
View directory record Official record
Conditions
Periodontitis
Interventions
SRP + MM, Scaling and Root Planing (SRP)
Procedure
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Sep 29, 2026, 2:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Utilization of a Periodontal Endoscope in Nonsurgical Periodontal Therapy

NCT05293301
View directory record Official record
Conditions
Periodontitis, Adult
Interventions
Use of Periodontal Endoscope (Perioscopy®) to enhance visualization while performing teeth deep cleaning, Use of traditional loupes to enhance magnification to enhance visualization while performing teeth deep cleaning
Device
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 23, 2022 · Synced Sep 29, 2026, 2:57 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Periodontal Inflammation and Epigenetics in Obese Individuals

NCT07610902
View directory record Official record
Conditions
Obesity, Periodontitis
Interventions
Non-surgical periodontal therapy will be administered
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 29, 2026, 2:57 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Adjunctive Hydrogen Peroxide for Periodontal Therapy

NCT03262701
View directory record Official record
Conditions
Periodontitis, Chronic
Interventions
Hydrogen Peroxide Gel, 13 weeks, Hydrogen Peroxide Gel, 26 weeks, Scaling and Root planing group
Drug · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Sep 29, 2026, 2:57 AM EDT