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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Scleral lens Clear all
Active, not recruiting Not applicable Interventional

Initial Correction Keratoconus

NCT04918316
View directory record Official record
Conditions
Keratoconus
Interventions
Corneal gas permeable lens
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Chicago, Illinois • Rochester, Minnesota • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 21, 2025 · Synced Sep 18, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Contact Lens Saline Solutions With Scleral GP Contact Lens Wearers Experiencing Fogging

NCT03525704
View directory record Official record
Conditions
Contact Lens Complication, Debris in Post Lens Tear Reservoir
Interventions
Saline Solution Enriched, Saline Rinse Solution
Device
Lead sponsor
Contamac Ltd
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
West Linn, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Sep 18, 2026, 2:06 PM EDT
Completed Not applicable Interventional

Scleral Contact Lens Insertion Solution Study

NCT03612284
View directory record Official record
Conditions
Irregular; Contour of Cornea
Interventions
contact lens insertion solution
Device
Lead sponsor
Jennifer Fogt
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 17, 2019 · Synced Sep 18, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of a Scleral Lens on the Anterior Chamber Depth and Minimum Rim Width

NCT03926975
View directory record Official record
Conditions
Ocular Hypertension
Interventions
Scleral Lens, No lens
Device · Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Sep 18, 2026, 2:06 PM EDT
Completed Not applicable Interventional Results available

Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye

NCT03417505
View directory record Official record
Conditions
Dry Eye, Dry Eye Syndromes
Interventions
Scleral lenses treated with Tangible Hydra-PEG, Untreated scleral lenses
Device
Lead sponsor
Tangible Science
Industry
Eligibility
18 Years to 70 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Sacramento, California • Fort Lauderdale, Florida • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 18, 2026, 2:06 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism

NCT04698590
View directory record Official record
Conditions
Keratoconus, Irregular Astigmatism, Corneal Ectasia, Aberration, Corneal Wavefront, Wavefront Aberration, Corneal, Pellucid Marginal Corneal Degeneration, Keratoglobus
Interventions
Wavefront Guided Scleral Lenses, Traditional Scleral Lenses
Device
Lead sponsor
Cornea and Laser Eye Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Teaneck, New Jersey
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Sep 18, 2026, 2:06 PM EDT
Not listed Phase 2Phase 3 Interventional

Safety and Efficacy of Pro-ocular™ 1% in Daily Scleral Lens Wearing Patients With Ocular Graft-versus-Host Disease

NCT04769648
View directory record Official record
Conditions
Ocular Graft-versus-host Disease
Interventions
Pro-ocular™ Topical Gel 1%, Placebo
Drug
Lead sponsor
Glia, LLC
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Needham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Sep 18, 2026, 2:06 PM EDT
Recruiting No phase listed Observational

The Effect of PROSE or Scleral Lenses on Mental Health

NCT07195721
View directory record Official record
Conditions
Depression - Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Boston Sight
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Needham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Sep 18, 2026, 2:06 PM EDT
Active, not recruiting Phase 1 Interventional

Stem Cell Therapy for Limbal Stem Cell Deficiency

NCT03957954
View directory record Official record
Conditions
Limbal Stem-cell Deficiency
Interventions
cLSC, Scleral contact lens (SCL)
Biological · Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 18, 2026, 2:06 PM EDT
Terminated Not applicable Interventional Results available

Intraocular Pressure in Ocular Hypertensives With Scleral Lens Wear

NCT04442464
View directory record Official record
Conditions
Ocular Hypertension
Interventions
Scleral Lens
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2024 · Synced Sep 18, 2026, 2:06 PM EDT
Completed Not applicable Interventional Results available

Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus

NCT03647046
View directory record Official record
Conditions
Keratoconus
Interventions
Customized Scleral Lens
Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 30, 2020 · Synced Sep 18, 2026, 2:06 PM EDT
Recruiting No phase listed Observational

Scleral Lens Fitting Using Wide-Field OCT

NCT04570020
View directory record Official record
Conditions
Keratoconus, Irregular; Contour of Cornea
Interventions
Not listed
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Sep 18, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Conjunctival Rebound After Scleral Lens Wear

NCT04340518
View directory record Official record
Conditions
Conjunctival Diseases
Interventions
Scleral lens
Device
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Sep 18, 2026, 2:06 PM EDT
Terminated Not applicable Interventional Results available

Maximizing the Initial Experience of a Neophyte Scleral Lens Wearer

NCT04583579
View directory record Official record
Conditions
Contact Lens Adaptation
Interventions
DMV inserter (DMV® MagicTouch™) with an open end, DMV inserter (DMV® MagicTouch™) with a closed end, Three fingers (Patient's Hand), O-ring (Hardware Store Product), Tea light candle (Generic Deparment Store Product) with DMV inserter (DMV® MagicTouch™)
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Sep 18, 2026, 2:06 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Effect of Ocular Hygiene on Scleral Lens Wear

NCT03544385
View directory record Official record
Conditions
Scleral Contact Lenses
Interventions
Ringers Solution, Placebo - Concentrate
Drug
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Sep 18, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tonometry Precision and Accuracy During PROSE Scleral Lens Wear: A Pilot Study

NCT04308941
View directory record Official record
Conditions
Intraocular Pressure and PROSE Lens
Interventions
Intraocular pressure
Diagnostic Test
Lead sponsor
Boston Sight
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Needham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 8, 2023 · Synced Sep 18, 2026, 2:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting

NCT04649177
View directory record Official record
Conditions
Keratoconus, Ocular Surface Disease, Pellucid Marginal Corneal Degeneration, Ectasia, Corneal Trauma, Corneal Scar, Dry Eye Syndromes, Keratoconjunctivitis Sicca, Sjogren's Syndrome
Interventions
Ocular surface optical coherence tomography
Device
Lead sponsor
Boston Sight
Other
Eligibility
21 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Needham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Sep 18, 2026, 2:06 PM EDT