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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Secondary Intention Healing Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Socket Preservation With BioHorizon's Striate+ Membrane and MinerOss X Plug

NCT05838651
View directory record Official record
Conditions
Socket Preservation
Interventions
MinerOss® X Plug, Striate+ Membrane
Device
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 2, 2025 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prospective Randomized Clinical Trial Comparing Outcomes of Secondary Intention Wound Care Methods

NCT03880331
View directory record Official record
Conditions
Wound Surgical, Wound Heal
Interventions
Debridement
Procedure
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Peabody, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional Results available

Massage Therapy in Treating the Symptoms of Patients With Locally Advanced or Metastatic Cancer

NCT00253708
View directory record Official record
Conditions
Cancer
Interventions
management of therapy complications, massage therapy, pain therapy, psychosocial assessment and care, quality-of-life assessment
Procedure
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 120 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2017 · Synced Sep 22, 2026, 6:25 PM EDT
Terminated Not applicable Interventional Results available

Doubleblinded RCT of the Omnilux on Lower Extremity Surgical Wounds Left to Heal by Second Intention

NCT02383056
View directory record Official record
Conditions
Wound
Interventions
Omnilux, Omnilux Sham
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 90 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced Sep 22, 2026, 6:25 PM EDT
Recruiting No phase listed Observational

CERAMENT G Device Registry

NCT06010433
View directory record Official record
Conditions
Chronic Osteomyelitis, Fracture Related Infection, Diabetic Foot Osteomyelitis
Interventions
CERAMENT G
Device
Lead sponsor
BONESUPPORT AB
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
3
States / cities
San Diego, California • Charlotte, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional Results available

Wet-to-dry vs Petrolatum & Non-stick Dressings After Hidradenitis Suppurativa Surgery

NCT05194969
View directory record Official record
Conditions
Hidradenitis Suppurativa, Surgical Wound
Interventions
Wet-to-Dry Dressings, Petrolatum with Non-Stick Gauze
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 99 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2025 · Synced Sep 22, 2026, 6:25 PM EDT
Not yet recruiting Phase 2 Interventional

Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds Healing

NCT07384767
View directory record Official record
Conditions
Mohs Micrographic Surgery, Excision Margin
Interventions
Timolol 0.5% Ophthalmic Solution, Hydrogel of placebo
Drug · Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional Results available

Sonendo GentleWave™ System for Treatment in Molar Teeth Requiring Root Canal Therapy

NCT02285595
View directory record Official record
Conditions
Root Canal Therapy
Interventions
Sonendo GentleWave™ System
Device
Lead sponsor
Sonendo, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
3
States / cities
Aliso Viejo, California • Santa Ana, California • Whittier, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2023 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional

Aesthetic Outcome of Complex Linear Closure vs Second Intention Healing: Below the Knee

NCT05074212
View directory record Official record
Conditions
Wound Heal, Wound of Skin
Interventions
Factorial Assignment
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 22, 2026, 6:25 PM EDT
Recruiting Not applicable Interventional

CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs

NCT07701590
View directory record Official record
Conditions
Wound, Foot, Diabetic Foot Ulcer (DFU), Venus Leg Ulcer
Interventions
Microlyte®, IP 1: Membrane Wrap - Hydro
Device
Lead sponsor
Capsicure, LLC
Network
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
7
States / cities
San Diego, California • Coral Gables, Florida • Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 22, 2026, 6:25 PM EDT
Terminated Not applicable Interventional Results available

Porcine Xenograft Versus Second Intention Healing

NCT03931746
View directory record Official record
Conditions
Wound Healing and Scar Quality Following Mohs Surgery and Excisional Dermatologic Surgery
Interventions
Porcine xenograft
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Bay Shore, New York • Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Mar 19, 2023 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional

Pinch Grafting Versus Second Intention Wound Healing for Mohs Micrographic Surgery Defects on the Scalp

NCT06287866
View directory record Official record
Conditions
Scarring
Interventions
Pinch Graft
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Socket Preservation Procedure Studying Soft and Hard Tissue Outcomes

NCT03497403
View directory record Official record
Conditions
Ridge Preservation, Bone Regeneration
Interventions
Socket preservation control, Socket preservation experimental
Procedure
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
20 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2018 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparison Between Primary and Secondary Flap Coverage in Extraction Sites: A Pilot Study

NCT03136913
View directory record Official record
Conditions
Loss of Teeth Due to Extraction
Interventions
Cytoplast® TXT-200, MinerOss® Cortical and Cancellous Chips (FDBA), Open Flap Technique, Closed Flap Technique
Device · Procedure
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 11, 2021 · Synced Sep 22, 2026, 6:25 PM EDT
Recruiting Phase 3 Interventional

The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal

NCT07142408
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Chlorhexidine gluconate (4%), Mupirocin 2% Ointment
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
848 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Marlton, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional Results available

Enhanced Secondary Intention Healing vs. Standard Secondary Intention Healing in Mohs Surgical Defects on the Head and Distal Lower Extremities

NCT04545476
View directory record Official record
Conditions
Wound Heal
Interventions
Participants in this group will receive the experimental APIS Biomaterial on the Head., Participants in this group will receive the experimental APIS Biomaterial on the Lower Extremities., Standard Secondary Intention Healing on the Head, Standard Secondary Intention Healing on the Lower Extremities
Device · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 11, 2023 · Synced Sep 22, 2026, 6:25 PM EDT
Terminated Not applicable Interventional Results available

Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery

NCT01442844
View directory record Official record
Conditions
Impaired Wound Healing
Interventions
Micrografting
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
40 Years to 75 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2014 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Platelets for Acute Wound Healing

NCT00125086
View directory record Official record
Conditions
Wounds
Interventions
autologous platelet gel
Device
Lead sponsor
Medtronic
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 13, 2005 · Synced Sep 22, 2026, 6:25 PM EDT
Not listed Phase 4 Interventional

Pilonidal Disease Wound Healing Study

NCT01857128
View directory record Official record
Conditions
Pilonidal Disease
Interventions
Drawtex dressing, Negative Pressure Wound Therapy
Device
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 19, 2013 · Synced Sep 22, 2026, 6:25 PM EDT
Not yet recruiting Phase 4 Interventional

Skin Subs vs Secondary Intention

NCT07587749
View directory record Official record
Conditions
Skin Substitutes, Secondary Intention Healing, Skin Cancer Healing
Interventions
Skin Substitute, Secondary Intention Healing
Biological
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 22, 2026, 6:25 PM EDT
Completed Not applicable Interventional

Evaluation of Purse-String Closure Vs Second Intention

NCT02062866
View directory record Official record
Conditions
Wound Closure Techniques
Interventions
Purse-String, Second Intent
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Sep 22, 2026, 6:25 PM EDT