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ClinicalTrials.gov public records Last synced Oct 19, 2026, 1:06 PM EDT

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Showing 361–384 of 729 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sedation Clear all
Terminated Phase 4 Interventional Results available

Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures

NCT03781817
View directory record Official record
Conditions
Trauma, Fractures, Closed, Children, Only, Deep Sedation, Ketamine
Interventions
Intravenous Ketamine, Intranasal Ketamine
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
1 Year to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Not applicable Interventional

Comparative Sedation Study of the MyoSure Hysteroscopic Tissue Removal System

NCT00979342
View directory record Official record
Conditions
Uterine Fibroids, Polyps
Interventions
Hysteroscopic Morcellator
Device
Lead sponsor
Hologic, Inc.
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
5
States / cities
Phoenix, Arizona • Boca Raton, Florida • Detroit, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2010 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Comparison of Procedural Sedation in TEE

NCT06129188
View directory record Official record
Conditions
Anesthesia
Interventions
Remimazolam, Propofol
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 89 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 19, 2026, 1:06 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Use of EndoFLIP and Manometry Prior to G-POEM

NCT04844190
View directory record Official record
Conditions
Gastroparesis
Interventions
EndoFLIP, Antroduodenal Manometry
Diagnostic Test
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate the Clinical Efficacy, Safety and Tolerability of ARX-F03 Sublingual Sufentanil/Triazolam NanoTab™ in Patients Undergoing an Elective Abdominal Liposuction Procedure

NCT00894699
View directory record Official record
Conditions
Sedation, Anxiety, Pain
Interventions
Sublingual Sufentanil/Triazolam NanoTab™ (ARX-F03), Placebo NanoTab™
Drug
Lead sponsor
Talphera, Inc
Industry
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2014 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Not applicable Interventional

Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial

NCT01269307
View directory record Official record
Conditions
Sedation
Interventions
1:1 ketamine-propofol mixture sedation, Propofol Sedation
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 12, 2014 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prevention and Treatment of Laryngospasm and Hypoxemia Based on Risk Factors in Adult Outpatients Undergoing EGD

NCT04159116
View directory record Official record
Conditions
Laryngospasm, Hypoxemia
Interventions
Prophylactic suctioning when clinically indicated
Other
Lead sponsor
Envision Healthcare Scientific Intelligence, Inc.
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Moon Township, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2021 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Not applicable Interventional Results available

Ketamine Infusion and Hypoventilation

NCT01535976
View directory record Official record
Conditions
Hypoventilation
Interventions
Placebo, Ketamine
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 1, 2014 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Not applicable Interventional Results available

Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia

NCT00717574
View directory record Official record
Conditions
Deep Sedation, Anesthesia, General
Interventions
Sevoflurane group, Propofol group
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Oct 19, 2026, 1:06 PM EDT
Withdrawn Not applicable Interventional

Comparison of High-flow Oxygen With or Without Nasal Positive Airway Pressure (PAP) During Propofol Sedation for Colonoscopy in an Ambulatory Surgical Center

NCT05754255
View directory record Official record
Conditions
Colonoscopy, Positive-Pressure Respiration
Interventions
Nasal Cannula, Nasal Positive Airway Pressure System
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 19, 2026, 1:06 PM EDT
Enrolling by invitation Phase 1 Interventional

Nitrous Oxide- Suicidal Ideation

NCT03736538
View directory record Official record
Conditions
Major Depressive Disorder, Depression, Mood Disorders, Suicidal Ideation
Interventions
Nitrous Oxide, Placebo gas
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Ultrasonic Deep Brain Stimulation During Anesthetic Sedation

NCT05495945
View directory record Official record
Conditions
Mental Function
Interventions
Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI) using Propofol
Device · Combination Product
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Oct 19, 2026, 1:06 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Dexmedetomidine Sedation With Third Molar Surgery

NCT01017237
View directory record Official record
Conditions
Anesthesia
Interventions
Dexmedetomidine, Midazolam, Ketamine
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 30 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2013 · Synced Oct 19, 2026, 1:06 PM EDT
Recruiting Early Phase 1 Interventional

FUSA With Intratumoral PolyICLC in Regionally Advanced Resectable Melanoma

NCT06472661
View directory record Official record
Conditions
Advanced Melanoma
Interventions
Echopulse or Echopulse HD, PolyICLC
Device · Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 19, 2026, 1:06 PM EDT
Withdrawn Phase 2 Interventional

Evaluation of a New EUS Guided Biopsy Needle (SharkCore) Comparing to Standard EUS Needle (ProCore)

NCT02766842
View directory record Official record
Conditions
Mesenchymal Tumor, Autoimmune Pancreatitis, Lymphoma, Solid Tumors
Interventions
EUS-FNB with ProCore needle, EUS-FNB with SharkCore needle, ProCore needle, SharkCore needle
Procedure · Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 15, 2017 · Synced Oct 19, 2026, 1:06 PM EDT
Enrolling by invitation Phase 2 Interventional Accepts healthy volunteers

Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study

NCT07705022
View directory record Official record
Conditions
Healthy, Covert Consciousness
Interventions
Dexmedetomidine (+propofol as indicated), Ketamine
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Phase 2 Interventional Results available

Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)

NCT04772222
View directory record Official record
Conditions
Hypoxic-Ischemic Encephalopathy, Pain
Interventions
Dexmedetomidine Hydrochloride, Morphine Sulfate
Drug
Lead sponsor
University of Utah
Other
Eligibility
Up to 24 Hours
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
5
States / cities
Murray, Utah • Ogden, Utah • Provo, Utah + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 19, 2026, 1:06 PM EDT
Completed No phase listed Observational

Sound Levels in the Pediatric Cardiac Critical Care Unit and Their Correlation With Sedation Administration, Delirium Scores and Patient Heart Rate

NCT04777695
View directory record Official record
Conditions
Noise Exposure, Sedative Withdrawal Delirium, Sedative Toxicity
Interventions
Decibel Monitor
Other
Lead sponsor
Children's National Research Institute
Other
Eligibility
Up to 22 Years
Enrollment
64 participants
Timeline
2021
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 1, 2021 · Synced Oct 19, 2026, 1:06 PM EDT
Not yet recruiting Phase 1 Interventional

Magnesium Sulfate in Pediatric Burn Dressing Changes

NCT07126795
View directory record Official record
Conditions
Pediatric Burns
Interventions
magnesium sulfate, Normal Saline (0.9% NaCl)
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
3 Years to 18 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients

NCT02548923
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Not applicable Interventional

Pain Procedures and Anxiolysis Via Distraction With Virtual Reality

NCT04437173
View directory record Official record
Conditions
Virtual Reality, Anxiety, Pain
Interventions
Virtual Reality Headset Distraction
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Phase 4 Interventional Results available

Oral Versus Intravenous Sedation for Ocular Procedures

NCT03246724
View directory record Official record
Conditions
Surgery, Sedation
Interventions
Triazolam, Midazolam, Microcrystalline Cellulose, Sodium chloride 0.9%
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2020 · Synced Oct 19, 2026, 1:06 PM EDT
Completed Not applicable Interventional Results available

Effect of Nasal Positive Airway Pressure Versus Standard Care on Oxygenation and Ventilation During Propofol-based Sedation for Colonoscopy in Patients With High Risk of Airway Obstruction

NCT05524220
View directory record Official record
Conditions
Obstructive Sleep Apnea, Obesity
Interventions
Standard care with a facemask., SuperNO2VA™EtCO2 (Nasal Oxygenating Ventilating Apparatus)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 19, 2026, 1:06 PM EDT
Recruiting Not applicable Interventional

The Efficacy of Distal Pharyngeal Airway for Oxygenation During TEE

NCT05974488
View directory record Official record
Conditions
Airway Obstruction
Interventions
McMurray Enhanced Airway, Nasal Cannula
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Oct 19, 2026, 1:06 PM EDT