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ClinicalTrials.gov public records Last synced Nov 12, 2026, 3:26 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 517 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sepsis Clear all

Conditions: Catheter-Related Infections
Interventions: Mino-Lok Therapy (MLT); Drug
Lead sponsor: Leonard-Meron Biosciences, Inc.; Industry
Eligibility: 12 Years and older
U.S. locations: 27
States / cities: Phoenix, Arizona • New Haven, Connecticut • Washington D.C., District of Columbia + 21 more

Conditions: Trauma Injury, Sepsis, Immunosuppression, Chronic Critical Illness
Interventions: Data Collection, Bone marrow collection and blood collection, Serial interviews to complete surveys and questionnaires, Telephone follow up call; Other · Procedure
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 100 Years
Enrollment: 255 participants
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Sepsis
Interventions: Complete Blood Count with differential; Diagnostic Test
Lead sponsor: Beckman Coulter, Inc.; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 524 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 5
States / cities: Indianapolis, Indiana • Kansas City, Kansas • Detroit, Michigan + 2 more

Conditions: Systemic Inflammatory Response Syndrome
Interventions: Azithromycin on admission - not enrolled in the RCT; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Sepsis
Interventions: Code Sepsis protocol (full implementation); Other
Lead sponsor: Intermountain Health Care, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 180,402 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 3
States / cities: Murray, Utah • Provo, Utah • St. George, Utah

Conditions: Septic Shock
Interventions: Simvastatin, Placebo; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Sepsis, Trauma, Infection
Interventions: 11-gene set; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Stanford, California

Conditions: Cardiovascular Disease, Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Deep Sternal Infection, Mediastinitis, Thoracotomy, Conduit Harvest or Cannulation Site, Sepsis, Pneumonia
Interventions: There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.; Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 79 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Sepsis, Trauma
Interventions: Etomidate, midazolam; Drug
Lead sponsor: Advocate Hospital System; Other
Eligibility: 18 Years and older
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Oak Lawn, Illinois

Conditions: Severe Sepsis
Interventions: Zinc sulfate; Dietary Supplement
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2025
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Staphylococcal Sepsis
Interventions: Placebo, Pagibaximab 50 mg/mL; Drug
Lead sponsor: Biosynexus Incorporated; Industry
Eligibility: Up to 48 Hours
Enrollment: 1,579 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Gaithersburg, Maryland

Conditions: Sepsis, Low Blood Pressure
Interventions: Midodrine, Standard of Care; Drug · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 308 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 5
States / cities: Scottsdale, Arizona • Jacksonville, Florida • Mankato, Minnesota + 2 more

Conditions: Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter
Interventions: Cook Spectrum Pediatric Central Venous Catheter Anti-microbial Impregnated Polyurethane and Arrow Pediatric Central Venous Catheter; Device
Lead sponsor: Corewell Health West; Other
Eligibility: Up to 18 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Grand Rapids, Michigan

Conditions: Severe Sepsis, Septic Shock, Sepsis
Interventions: Not listed
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Acute Kidney Injury, Chronic Kidney Disease, Hypertension
Interventions: Iodohippurate, 24 hour ambulatory Blood Pressure, Peripheral Arterial Tonometry, Pulse Wave Velocity, Gadolinium; Drug · Procedure
Lead sponsor: University of Florida; Other
Eligibility: 7 Years to 17 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Preterm Infant, Early-Onset Neonatal Sepsis, Umbilical Cord
Interventions: Placental/Umbilical Cord Blood sample; Other
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: Up to 1 Day
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Nosocomial Infections, Sepsis, Staphylococcal Infections, Candidemia
Interventions: Veronate; Drug
Lead sponsor: Bristol-Myers Squibb; Industry
Eligibility: 3 Days to 5 Days
Enrollment: 2,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 85
States / cities: Birmingham, Alabama • Mobile, Alabama • Anchorage, Alaska + 71 more

Conditions: Pediatric Sepsis
Interventions: For group Peds Sep A: Standard nutrition will be given, For Group Peds SepB: Low leucine, isoleucine formula, For Group Peds Sep C: Medium chain triglyceride oil enriched formula., For Group Peds Sep D: Low carbohydrate ketogenic formula; Dietary Supplement
Lead sponsor: University of Pittsburgh; Other
Eligibility: 44 Weeks to 17 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Severe Sepsis, Acute Lung Injury
Interventions: High Dose Citrulline, Placebo, Low Dose Citrulline; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 13 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Sepsis, Septic Shock, Hypotension, Acute Lung Injury
Interventions: Ascorbic Acid, Placebo; Drug
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Septic Shock
Interventions: LB1148, Placebo; Drug
Lead sponsor: Leading BioSciences, Inc; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 26
States / cities: Mobile, Alabama • Fresno, California • Long Beach, California + 23 more

Conditions: Sepsis, Premature Birth
Interventions: Not listed
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 0 Days to 2 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Early Onset Sepsis, Preterm Neonates, NICU, Ampicillin, Safety and Pharmacokinetics
Interventions: Ampicillin prescribed by provider per standard of care for evaluation of early onset sepsis; Drug
Lead sponsor: Duke University; Other
Eligibility: 0 Days to 7 Days
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Sepsis, Septic Shock, Sepsis, Severe, Volume Overload
Interventions: VExUS score; Diagnostic Test
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older
Enrollment: 152 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Search by objective public record fields.

Expanded Access: Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI

Pathological Myeloid Activation After Sepsis and Trauma

Adult MDW Dual Cut-Off Accuracy Study

Efficacy of Macrolide Immunomodulation in Severe Sepsis.

Effects of Code Sepsis Implementation on Emergency Department (ED) Sepsis Care

Statin Therapy in the Treatment of Sepsis

Longitudinal Gene Expression Profiling in Adults After Traumatic Injury

Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2

The Effect of Etomidate on Patient Outcomes After Single Bolus Doses

Zinc Therapy in Critical Illness

Safety and Efficacy of Pagibaximab Injection in Very Low Birth Weight Neonates for Prevention of Staphylococcal Sepsis

MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial

Study of the Use of Coated Venous Catheters in the Critically Ill Child

The Role of Dysfunctional HDL in Severe Sepsis

Severe Sepsis in Children - IMPRESS-C

Utility of Placental/Umbilical Cord Blood in Early Onset Neonatal Sepsis in Very Low Birth Weight Infants

Safety and Efficacy of Veronate® Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants

Personalized Metabolic Nutrition Sepsis Study

Citrulline in Severe Sepsis

Ascorbic Acid (Vitamin C) Infusion in Human Sepsis

Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148

Predictors of Sepsis in Ex-Preterm Infants

Optimizing PreTerm Infant Ampicillin Dosing

De-resuscitation Informed by Ultrasound for Patients With Sepsis