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Showing 1–24 of 35 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Serious games Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of a "Serious Game" on Improving Patient's Medication Knowledge

NCT01786044
View directory record Official record
Conditions
Health Knowledge, Attitudes, Practice
Interventions
MasterMed, Usual Care
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
850 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2017 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic

NCT04920123
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Neuro-World
Device
Lead sponsor
University of Massachusetts, Amherst
Other
Eligibility
55 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Amherst, Massachusetts • Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Sep 4, 2026, 2:17 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Project Talk Trial: Engaging Underserved Communities in End-of-life Conversations

NCT04612738
View directory record Official record
Conditions
Advance Care Planning, Advance Directives, Terminal Illness, Chronic Illness, Communication
Interventions
Hello (serious game), The Conversation Project (CP) Starter Kit, Table Topics (general conversation game)
Behavioral · Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
79
States / cities
Athens, Alabama • Kingman, Arizona • Show Low, Arizona + 70 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 4, 2026, 2:17 AM EDT
Not listed Not applicable Interventional

Serious Games for Parkinson's Disease

NCT05551338
View directory record Official record
Conditions
Parkinson Disease, Parkinson
Interventions
Serious games
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Socially Assistive Robots for Interaction With Older Adults With Dementia

NCT04384978
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Play Serious Games with a Social Robot (Ryan), Play Solitary Games Without a Social Robot
Behavioral
Lead sponsor
DreamFace Technologies, LLC
Industry
Eligibility
65 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Sep 4, 2026, 2:17 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

EFFECTIVENESS: Hopewell Hospitalist: A Video Game Intervention to Increase Advance Care Planning by Hospitalists

NCT04881968
View directory record Official record
Conditions
Advance Care Planning
Interventions
Hopewell Hospitalist Video Game
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
Not listed
Enrollment
1,261 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Feb 24, 2022 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Phase 2 Interventional

Using Serious Game Technology to Improve Sensitivity to Eye Gaze in Autism

NCT02968225
View directory record Official record
Conditions
Autism
Interventions
Computer Game
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
10 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 4, 2021 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional

Clinical Trial of a Serious Game for Individuals With SCI/D

NCT02341950
View directory record Official record
Conditions
Spinal Cord Injury, Spinal Cord Involvement, Spina Bifida, Transverse Myelitis, Polio and Post-polio Syndrome, Syringomyelia, Spinal Stenosis, Spinal Neoplasms, Spinal Cord Diseases
Interventions
SCI Hard
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
13 Years to 29 Years
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Sep 4, 2026, 2:17 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Gathering Evidence on Best Practices for Lay Rescuer CPR Training

NCT05908500
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital
Interventions
CPR Training, CPR Manikin Type
Behavioral · Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
Not listed
Enrollment
2,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

All About Me: An Intervention to Ease the Transition to Long Term Care

NCT05516134
View directory record Official record
Conditions
Dementia, Alzheimer Disease, Dementia, Vascular, Dementia, Mixed, Dementia of Alzheimer Type
Interventions
SAFE at Home
Behavioral
Lead sponsor
Hopeful Aging
Industry
Eligibility
60 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Winchester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Sep 4, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional

Serious Gaming for Chemotherapy-induced Nausea and Vomiting

NCT05838638
View directory record Official record
Conditions
Neoplasms, Chemotherapy-induced Nausea and Vomiting
Interventions
eSSET-CINV
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
60 Years and older
Enrollment
610 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Miami, Florida • Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Pegasys VR: Integrating Virtual Humans in the Treatment of Child Social Anxiety

NCT02816684
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Pegasys-VR, Social Effectiveness Therapy for Children
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
7 Years to 12 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 18, 2018 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interactive Digital Intervention to Prevent Violence Among Young Adults

NCT03820609
View directory record Official record
Conditions
Sexual Assault
Interventions
Digital Intervention
Behavioral
Lead sponsor
Happy People Games, LLC
Other
Eligibility
18 Years to 24 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
Warwick, Rhode Island • Clemson, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2019 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Phase 2 Interventional

Efficacy of a Self-advocacy Serious Game Intervention

NCT04813276
View directory record Official record
Conditions
Self-Management, Quality of Life
Interventions
Strong Together serious game, Enhanced Care as Usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Real-World Study of a Mobile Device-based Serious Health Game on Session Attendance in the National Diabetes Prevention Program

NCT05039970
View directory record Official record
Conditions
Diabetes Mellitus Risk, Diabetes Mellitus
Interventions
WellQuest™
Other
Lead sponsor
BioCentric, Inc.
Other
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Collingswood, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 1, 2022 · Synced Sep 4, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional

Novel Amblyopia Treatment With Virtual Reality Games

NCT06049459
View directory record Official record
Conditions
Amblyopia
Interventions
Optical Correction, Therapeutic Dichoptic Virtual Reality Games
Device
Lead sponsor
Marjean Kulp
Other
Eligibility
5 Years to 17 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional

Self-Advocacy Serious Game in Advanced Cancer

NCT03339765
View directory record Official record
Conditions
Ovarian Cancer Stage III, Ovarian Cancer Stage IV, Breast Cancer Stage IV, Cervical Cancer Stage IIIB, Cervical Cancer Stage IVA, Cervical Cancer Stage IVB, Endometrial Cancer Stage III, Endometrial Cancer Stage IV, Vulvar Cancer, Stage III, Vulvar Cancer, Stage IV, Vaginal Cancer Stage III, Vaginal Cancer Stage IVA, Vaginal Cancer Stage IVB
Interventions
Strong Together serious game
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 4, 2023 · Synced Sep 4, 2026, 2:17 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

An Evidence-based Approach for Bullying Prevention

NCT03205059
View directory record Official record
Conditions
Bullying, Cyberbullying, Substance Use, Substance Abuse
Interventions
LST MS curriculum+ Bullying/Cyberbulling serious game, LST MS curriculum
Behavioral
Lead sponsor
National Health Promotion Associates, Inc.
Industry
Eligibility
11 Years to 14 Years
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2019 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Using an End-of-life Conversation Game to Engage Underserved Communities in Advance Care Planning

NCT03456921
View directory record Official record
Conditions
Advance Care Planning, Vulnerable Populations, Advance Directives, Terminal Illness
Interventions
End-of-life conversation game called "Hello"
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2019 · Synced Sep 4, 2026, 2:17 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

EMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke

NCT05628324
View directory record Official record
Conditions
Stroke
Interventions
practice muscle activation patterns, task practice
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Sep 4, 2026, 2:17 AM EDT
Not yet recruiting Not applicable Interventional

MedSMA℞T Mobile ED

NCT06848504
View directory record Official record
Conditions
Opiate-Related Disorders, Opiate Use Disorder, Opioid
Interventions
MedSMA℞T Mobile
Behavioral
Lead sponsor
Olufunmilola Abraham
Other
Eligibility
12 Years and older
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Rockford, Illinois • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Results available

Testing the Effectiveness of Night Shift, a Theory-based Customized Video Game

NCT06063434
View directory record Official record
Conditions
Trauma Injury, Physician's Role
Interventions
Night Shift, Usual education
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
25 Years to 70 Years
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 4, 2026, 2:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Oral Health With Serious Games

NCT02027597
View directory record Official record
Conditions
Caries, Tooth Decay, Cavities, Gingivitis
Interventions
Attack of the S. Mutans, Follow-up, SnowWorld
Other
Lead sponsor
University of Washington
Other
Eligibility
8 Years to 12 Years
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 5, 2014 · Synced Sep 4, 2026, 2:17 AM EDT
Not listed Not applicable Interventional

Development of a Game-supported Intervention

NCT05048043
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder
Interventions
Computer-assisted Behavior Intervention, Challenging Horizons Program
Behavioral
Lead sponsor
East Carolina University
Other
Eligibility
11 Years to 14 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Greenville, North Carolina • Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 16, 2022 · Synced Sep 4, 2026, 2:17 AM EDT