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ClinicalTrials.gov public records Last synced Oct 24, 2026, 10:34 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 1,656 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sham (Control) Clear all
Completed Not applicable Interventional

Normal Saline Use With Suctioning

NCT02612961
View directory record Official record
Conditions
Tracheostomy
Interventions
3mL of normal saline from the pink sodium chloride bullet, Sham Comparator of 3mL normal saline
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Oct 24, 2026, 10:34 PM EDT
Recruiting Not applicable Interventional

Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy

NCT06686680
View directory record Official record
Conditions
Knee Osteoarthristis, ACL Injuries, Post-Traumatic
Interventions
extracorporeal shockwave therapy (ESWT), Sham Comparator
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Not applicable Interventional Results available

Cooling to Alleviate Migraine #3

NCT06874361
View directory record Official record
Conditions
Migraine With or Without Aura, Migraine, Migraine Headache
Interventions
Mi-Helper
Device
Lead sponsor
Mi-Helper, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Indian Harbour Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Phase 2 Interventional Results available

Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke

NCT02448641
View directory record Official record
Conditions
Chronic Ischemic Stroke
Interventions
SB623 Implant (2.5M), SB623 Implant (5.0M), Sham surgery
Biological · Procedure
Lead sponsor
SanBio, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
65
States / cities
Birmingham, Alabama • Phoenix, Arizona • Carlsbad, California + 43 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 24, 2026, 10:34 PM EDT
Recruiting Not applicable Interventional

Early Neuromodulation in Traumatic Brain Injury

NCT06871124
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
transcranial electrical stimulation, Sham Comparator
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Phase 3 Interventional

Vamikibart in Participants With Uveitic Macular Edema

NCT05642325
View directory record Official record
Conditions
Uveitic Macular Edema
Interventions
Vamikibart, Sham
Drug · Other
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
23
States / cities
Phoenix, Arizona • Sun City, Arizona • Fullerton, California + 19 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Not applicable Interventional Results available

Resin Infiltration to Arrest Early Tooth Decay

NCT01584024
View directory record Official record
Conditions
Dental Caries
Interventions
Resin infiltration, Sham treatment
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2019 · Synced Oct 24, 2026, 10:34 PM EDT
Not yet recruiting Not applicable Interventional

Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome

NCT06953661
View directory record Official record
Conditions
Postural Tachycardia Syndrome
Interventions
Stellate ganglion block, Sham injection of saline, Ropivacaine, Normal saline
Procedure · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Not applicable Interventional

Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window

NCT00826059
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Active Sphenopalatine Ganglion (SPG) Stimulation, Sham Sphenopalatine Ganglion (SPG) Stimulation
Device
Lead sponsor
BrainsGate
Industry
Eligibility
40 Years to 85 Years
Enrollment
1,078 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
7
States / cities
Sarasota, Florida • Winfield, Illinois • Greensboro, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Oct 24, 2026, 10:34 PM EDT
Recruiting Phase 3 Interventional

Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury

NCT06581003
View directory record Official record
Conditions
Traumatic Brain Injury, Military Operations
Interventions
Oxygen 99.7 %, Oxygen 21 %
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Phase 1Phase 2 Interventional Results available

HORNBILL: A Study to Test Different Doses of BI 764524 in Patients Who Have Had Laser Treatment for a Type of Diabetic Eye Disease Called Diabetic Retinopathy With Diabetic Macular Ischemia

NCT04424290
View directory record Official record
Conditions
Diabetic Retinopathy
Interventions
BI 764524, Sham control of BI 764524
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
13
States / cities
Dothan, Alabama • Beverly Hills, California • Palo Alto, California + 10 more
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Oct 24, 2026, 10:34 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vaginal Changes After CO2 Laser

NCT06691178
View directory record Official record
Conditions
Genitourinary Syndrome of Menopause
Interventions
Optical coherence tomography (OCT)
Diagnostic Test
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Active, not recruiting Not applicable Interventional

Dry Needling and Shoulder Muscle Blood Flow, Motions, and Pain Sensitivity in Individuals with Shoulder Pain

NCT05596240
View directory record Official record
Conditions
Dry Needling, Shoulder Pain
Interventions
Dry Needling, Sham Dry Needling
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Not applicable Interventional Results available

Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation

NCT06071715
View directory record Official record
Conditions
Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
Interventions
ACTIVE cryoneurolysis, SHAM cryoneurolysis
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Acupressure for Fatigue in Systemic Lupus Erythematosus

NCT03200548
View directory record Official record
Conditions
Fatigue, Lupus Erythematosus, Systemic, Pain, Chronic, Quality of Life, Sleep
Interventions
Relaxing acupressure plus usual care, Usual care, Stimulating acupressure plus usual care, Sham acupressure plus usual care
Behavioral
Lead sponsor
Suzanna Zick
Other
Eligibility
18 Years and older · Female only
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 12, 2023 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Not applicable Interventional

Lumbar Manipulation and Exercise for the Treatment of Acute Low Back Pain in Adolescents

NCT02111278
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham Manipulation, Physical Therapy
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
13 Years to 17 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
3
States / cities
Columbus, Ohio • Westerville, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 23, 2014 · Synced Oct 24, 2026, 10:34 PM EDT
Recruiting Phase 4 Interventional

Trial to Evaluate Cyclical Topical Wound Oxygen Therapy in the Treatment of Chronic Venous Leg Ulcers

NCT06754735
View directory record Official record
Conditions
Venous Leg Ulcer (VLU)
Interventions
Topical Wound Oxygen Therapy, Sham Control Topical Wound Oxygen
Device
Lead sponsor
AOTI Ltd.
Industry
Eligibility
18 Years and older
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 24, 2026, 10:34 PM EDT
Terminated Not applicable Interventional

Efficacy of BFR Training Combined With Eccentric Exercise as Assessed by SWE in Subjects With Chronic AT

NCT03264326
View directory record Official record
Conditions
Achilles Tendinopathy
Interventions
Blood Flow Restriction Training, Sham Blood Flow Restriction Training, Eccentric Exercise
Other
Lead sponsor
Womack Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated May 15, 2019 · Synced Oct 24, 2026, 10:34 PM EDT
Active, not recruiting Phase 1 Interventional

GDNF Gene Therapy for Multiple System Atrophy

NCT04680065
View directory record Official record
Conditions
Multiple System Atrophy
Interventions
AAV2-GDNF gene therapy, Sham (Placebo) Surgery
Biological · Procedure
Lead sponsor
Brain Neurotherapy Bio, Inc.
Industry
Eligibility
35 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
7
States / cities
Irvine, California • Boca Raton, Florida • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Recruiting Not applicable Interventional

Ultrasound Neuromodulation in Essential Tremor

NCT06610877
View directory record Official record
Conditions
Essential Tremor, Neuromodulation
Interventions
Focused Ultrasound Neuromodulation - Sham Control, Focused ultrasound neuromodulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Recruiting Not applicable Interventional

Neuromodulation of Inflammation and Endothelial Function

NCT05230732
View directory record Official record
Conditions
Systolic Heart Failure
Interventions
neuromodulation device, SHAM
Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 85 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 24, 2026, 10:34 PM EDT
Not listed Early Phase 1 Interventional

Photobiomodulation to Improve Cognition in TBI, With fMRI

NCT04230577
View directory record Official record
Conditions
Traumatic Brain Injury, Closed Head Injury, Cognitive Dysfunction
Interventions
Real LED Intervention, Sham LED Intervention
Device
Lead sponsor
Boston VA Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2022 · Synced Oct 24, 2026, 10:34 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study Effects of Intermittent Hypoxia on Restoring Hand Function Following SCI

NCT01272336
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Acute Intermittent Hypoxia (AIH), SHAM-Intermittent Room Air
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 26, 2016 · Synced Oct 24, 2026, 10:34 PM EDT
Enrolling by invitation Not applicable Interventional

Peripheral Neurostimulation for Nerve Block Placement

NCT06566664
View directory record Official record
Conditions
Pain Syndrome, Pain Management
Interventions
B Braun HNS 12 nerve stimulator, B Braun HNS 12 nerve stimulator sham control
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 24, 2026, 10:34 PM EDT