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ClinicalTrials.gov public records Last synced Nov 7, 2026, 1:44 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1489–1512 of 1,664 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Sham (Control) Clear all

Conditions: Pediatric Obesity, Pediatric Asthma
Interventions: Pro2 - 60% of participant's MIP, Pro2 - 15% of participant's MIP; Device
Lead sponsor: Duke University; Other
Eligibility: 8 Years to 17 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Major Depressive Disorder
Interventions: CT-152 - Digital Therapeutic, Sham; Device
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 22 Years to 64 Years
Enrollment: 386 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Idiopathic Interstitial Pneumonias / Hypertension,Pulmonary
Interventions: Riociguat (Adempas, BAY63-2521), Placebo; Drug
Lead sponsor: Bayer; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 147 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 17
States / cities: Los Angeles, California • San Francisco, California • Aurora, Colorado + 14 more

Conditions: Intraocular Pressure
Interventions: Brimonidine, Tropicamide, Phenylephrine Ophthalmic Product; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 50 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Uveitis, Uveitis, Posterior, Uveitis, Anterior, Uveitis, Intermediate
Interventions: Yutiq 0.18 MG Drug Implant, Sham Injection; Drug · Other
Lead sponsor: Texas Retina Associates; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Plano, Texas

Conditions: Lower Back Pain
Interventions: The Transdiscal Radiofrequency Annuloplasty; Device
Lead sponsor: Baylis Medical Company; Industry
Eligibility: 18 Years and older
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 2
States / cities: Winston-Salem, North Carolina • Cleveland, Ohio

Conditions: Convergence Insufficiency
Interventions: Office Based Vergence and Accommodative Therapy; Behavioral
Lead sponsor: New Jersey Institute of Technology; Other
Eligibility: 18 Years to 35 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Newark, New Jersey

Conditions: Threat-related Sensory Cortical (SC) Disinhibition, Posttraumatic Stress Disorder (PTSD)
Interventions: Transcranial Alternating Current Stimulation (tACS), Sham for Transcranial Alternating Current Stimulation (tACS), Transcranial Random Noise stimulation (tRNS); Device
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 50 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Macular Edema, Central Retinal Vein Occlusion, Hemiretinal Vein Occlusion
Interventions: Faricimab, Aflibercept, Sham Procedure; Drug · Procedure
Lead sponsor: Hoffmann-La Roche; Industry
Eligibility: 18 Years and older
Enrollment: 729 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 57
States / cities: Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 52 more

Conditions: Migraine, Heart Rate Variability (HRV), Autonomic Nervous System, Headache (Migraine), Headache, Chronic Pain, mHealth, Breathing
Interventions: Baseline Survey, Heart rate variability biofeedback, Sham Control Group; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Hemiparesis, Stroke
Interventions: rTMS, BCI Training; Device · Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Gastrointestinal Infection, Respiratory Viral Infection
Interventions: Active household UV water treatment device, Inactive household UV water treatment device; Device
Lead sponsor: Temple University; Other
Eligibility: 6 Months to 59 Months
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Otitis Media With Effusion
Interventions: OTO-201, Sham; Drug
Lead sponsor: Otonomy, Inc.; Industry
Eligibility: 6 Months to 17 Years
Enrollment: 266 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Ischemic Stroke
Interventions: Active Sphenopalatine Ganglion (SPG) Stimulation, Sham Sphenopalatine Ganglion (SPG) Stimulation; Device
Lead sponsor: BrainsGate; Industry
Eligibility: 40 Years to 85 Years
Enrollment: 1,078 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2018
U.S. locations: 7
States / cities: Sarasota, Florida • Winfield, Illinois • Greensboro, North Carolina + 3 more

Conditions: Shoulder Adhesive Capsulitis, Shoulder Pain, Frozen Shoulder
Interventions: Dry needling, Sham Dry Needling, Therapeutic Exercise; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Hypertension, High Blood Pressure
Interventions: ROX Coupler, Sham procedure; Device · Other
Lead sponsor: ROX Medical, Inc.; Industry
Eligibility: 22 Years to 85 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 13
States / cities: Birmingham, Alabama • Gainesville, Florida • Atlanta, Georgia + 9 more

Conditions: Advanced Malignant Neoplasm
Interventions: Fat Emulsion, Placebo; Dietary Supplement · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Spinal Cord Injuries, Tetraplegia
Interventions: bihemispheric transcranial pulsed current stimulation (tPCS), unihemispheric transcranial pulsed current stimulation (tPCS), bihemispheric transcranial direct current stimulation (tDCS), unihemispheric transcranial direct current stimulation (tDCS), sham-control; Other
Lead sponsor: Shepherd Center, Atlanta GA; Other
Eligibility: 18 Years to 65 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Osteopathic Manual Manipulation of Neurovascular Regulation
Interventions: Osteopathic Manual Medicine, Sham; Other
Lead sponsor: New York Institute of Technology; Other
Eligibility: 20 Years to 50 Years
Enrollment: 126 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Old Westbury, New York

Conditions: BPH (Benign Prostatic Hyperplasia), Lower Urinary Tract Symptoms (LUTS)
Interventions: Butterfly Prostatic Retraction Device; Device
Lead sponsor: Butterfly Medical Ltd.; Industry
Eligibility: 50 Years to 120 Years · Male only
Enrollment: 245 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2029
U.S. locations: 3
States / cities: New York, New York • Syosset, New York • Houston, Texas

Conditions: Cerebral Palsy
Interventions: Cord Blood Infusion, Intravenous Sham; Biological
Lead sponsor: Augusta University; Other
Eligibility: 1 Year to 12 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2019
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: Obstructive Sleep Apnea (OSA)
Interventions: Pillar Palatal Implant System, Sham system; Device
Lead sponsor: Medtronic Xomed, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 7
States / cities: Little Rock, Arkansas • Berkeley, California • Denver, Colorado + 4 more

Conditions: Subacromial Impingement Syndrome
Interventions: Standard Physical Therapy Treatment, Dry Needling, Sham Dry Needling; Procedure
Lead sponsor: 59th Medical Wing; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 121 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Pollution; Exposure, Smoke Inhalation, Exposure to Pollution
Interventions: Cigarette Smoke, Clean Air and Clean Clothing/Sham exposure; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 50 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: San Francisco, California

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Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma

Trial to Evaluate the Effectiveness of a Digital Therapeutics in Adults Diagnosed With Major Depressive Disorder

Efficacy and Safety of Riociguat in Patients With Symptomatic Pulmonary Hypertension (PH) Associated With Idiopathic Interstitial Pneumonias (IIP)

The Effect of Brimonidine

The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment

Placebo-controlled Trial of Transdiscal Radiofrequency Annuloplasty

Neural Mechanism of Vision Therapy for Patients With Convergence Insufficiency

A Neurosensory Account of Anxiety and Stress (Study 2)

A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion

App-based Breathing Program for Migraine Relief

A Brain Centered Neuroengineering Approach for Motor Recovery After Stroke: Combined rTMS and BCI Training

Wells and Enteric Disease Transmission Trial (WET - Trial)

OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement

Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window

Dry Needling for Shoulder Adhesive Capsulitis

A Multicenter Study to Evaluate the ROX Coupler in Subjects With Hypertension

Fat Emulsion in Preventing Hypersensitivity Reactions in Patients With Cancer Receiving Carboplatin or Oxaliplatin

Enhancing Corticospinal Excitability to Improve Functional Recovery

Study of Osteopathic Manipulative Medicine on the Autonomic Nervous System

Butterfly Pivotal Study

Safety and Effectiveness of Cord Blood Stem Cell Infusion for the Treatment of Cerebral Palsy in Children

Palatal Implants in Combination With Continuous Positive Airway Pressure to Treat Obstructive Sleep Apnea

Dry Needling for Sub Acromial Pain Syndrome

Controlled Exposure of Healthy Nonsmokers to Secondhand and Thirdhand Cigarette Smoke