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Showing 1–24 of 109 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sham Auricular Stimulation Clear all
Recruiting Not applicable Interventional

Evaluating Noninvasive Brain Stimulation for TMD Pain: A Feasibility Study

NCT07517172
View directory record Official record
Conditions
Temporomandibular Disorder
Interventions
Transcutaneous Auricular Neurostimulation, Sham Stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Active, not recruiting Not applicable Interventional

Transdermal Vagal Stimulation for POTS

NCT02281097
View directory record Official record
Conditions
Postural Orthostatic Tachycardia Syndrome
Interventions
Stimulation, Placebo
Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 75 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Anti-inflammatory Actions of Osteopathic Manipulative Treatment

NCT04177264
View directory record Official record
Conditions
Inflammation
Interventions
Occipito-Atlantal Decompression (OA DC), Sham Occipito-Atlantal Decompression (Sham OA DC), Splenic Lymphatic Pump Technique (SpLPT), Sham Splenic Lymphatic Pump Technique (Sham SpLPT), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham Transcutaneous Auricular Vagus Nerve Stimulation (Sham taVNS)
Procedure · Device
Lead sponsor
Burrell College of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Las Cruces, New Mexico
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 7, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia

NCT07191119
View directory record Official record
Conditions
Survivor of Childhood Cancer, Insomnia, Acute Lymphoblastic Leukemia (ALL)
Interventions
Soterix tVNS device, Soterix tVNS device (sham programmed), Sleep Quality, Neurocognitive and mental health outcomes
Device · Behavioral
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
20 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Completed Not applicable Interventional Results available

Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct

NCT05390580
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
transcutaneous auricular vagal nerve stimulation, Sham transcutaneous vagal nerve stimulation
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 7, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

NCT07424365
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
Interventions
transcutaneous auricular vagus nerve stimulation, sham stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Completed Not applicable Interventional

tAN for PTSD and OUD in Buprenorphine Therapy

NCT06130501
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Opioid Use Disorder
Interventions
Sparrow Ascent tAN, Sparrow Ascent Active Sham
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cape Girardeau, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Withdrawn Not applicable Interventional

Using Transcutaneous Auricular Vagus Nerve Stimulation to Treat Acute Alcohol Withdrawal

NCT04159909
View directory record Official record
Conditions
Alcohol Withdrawal, Alcohol Use Disorder
Interventions
Transcutaneous Nerve Stimulation, Sham Stimulation
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Sep 7, 2026, 4:26 PM EDT
Not yet recruiting Not applicable Interventional

Effects of taVNS on Fibromyalgia Pain

NCT06193317
View directory record Official record
Conditions
Fibromyalgia, Pain
Interventions
Transauricular vagus nerve stimulation (taVNS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years and older
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 7, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional

A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness

NCT07420803
View directory record Official record
Conditions
Chronic Dizziness, Persistent Postural Perceptual Dizziness
Interventions
Sham Device, Auricular transcutaneous vagus nerve stimulation
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Not listed Not applicable Interventional

Effect of taVNS on Heart Rate in Persistent Atrial Fibrillation

NCT05944575
View directory record Official record
Conditions
Atrial Fibrillation, Persistent
Interventions
active taVNS, sham-taVNS
Device
Lead sponsor
Burrell College of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Las Cruces, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Sep 7, 2026, 4:26 PM EDT
Completed Not applicable Interventional

Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)

NCT04607226
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active transcutaneous vagus nerve stimulation, Sham transcutaneous vagus nerve stimulation
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
24 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 31, 2023 · Synced Sep 7, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

NCT07218133
View directory record Official record
Conditions
Spinal Fusion, Hyperglycemia, Postoperative Pain Management, Postoperative Care, Spine Disease, Neurologic Deficits, Neurological Disorder, Inflammation, Spine Condition, Spinal (Fusion) Surgery, Cytokine Levels, Spine Fusion
Interventions
Auricular vagus nerve stimulation, Sham Auricular Vagus nerve Stimulation
Device
Lead sponsor
Alexander T. Yahanda
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Terminated Not applicable Interventional

Use of tAN® in Alcohol Withdrawal Management

NCT06771037
View directory record Official record
Conditions
Alcohol Withdrawal
Interventions
Transcutaneous Auricular Neurostimulation (tAN)
Device
Lead sponsor
Erin Takemoto
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Wernersville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation

NCT06892340
View directory record Official record
Conditions
Motion Sickness
Interventions
Transcutaneous Auricular Neurostimulation device
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
18 Years to 50 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Sep 7, 2026, 4:26 PM EDT
Not listed Not applicable Interventional

Augmenting Standard-of-care Treatment of Plaque Psoriasis by Neuromodulation

NCT05243303
View directory record Official record
Conditions
Psoriasis Vulgaris
Interventions
Active taVNS, Sham taVNS
Device
Lead sponsor
Burrell College of Health Sciences
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Las Cruces, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Sep 7, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Augmentation Via Multimodal Sensing and Auricular Neurostimulation

NCT06782360
View directory record Official record
Conditions
Healthy, Cognitive Change, Effects of External Neurostimulation on Cognition
Interventions
Active Neurostimulation, Sham Stimulation
Device
Lead sponsor
OpenBCI
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Completed Not applicable Interventional Results available

Using the Cholinergic Anti-Inflammatory Pathway to Treat Systemic Lupus Musculoskeletal Pain

NCT02822989
View directory record Official record
Conditions
Lupus Erythematosus, Systemic, Musculoskeletal Pain
Interventions
Vagus nerve stimulation, Sham vagus nerve stimulation
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Non-Invasive Bioelectronic Analytics

NCT04100486
View directory record Official record
Conditions
Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
Interventions
Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Other · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Not yet recruiting Early Phase 1 Interventional

Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD

NCT06953388
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder
Interventions
transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Defining Adolescent Nausea Through Brain Imaging and Neurostimulation Response

NCT03675321
View directory record Official record
Conditions
Functional Gastrointestinal Disorders
Interventions
Active Auricular Neurostimulation, Sham Auricular Neurostimulation
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
11 Years to 18 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Sep 7, 2026, 4:26 PM EDT
Completed No phase listed Interventional Accepts healthy volunteers Results available

Examining Transcutaneous Vagal Nerve Stimulation as a Facilitator of Social Bonding

NCT05899413
View directory record Official record
Conditions
Vagus Nerve Stimulation
Interventions
Transcutaneous vagal nerve stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 39 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Sep 7, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional

Delivering Transcutaneous Auricular Neurostimulation to Reduce Blood Loss During Dialysis AV Graft Placement Procedures

NCT06647017
View directory record Official record
Conditions
Blood Loss, Surgical
Interventions
Volta tAN System, SHAM Volta tAN System
Device
Lead sponsor
University Surgical Vascular
Industry
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Watkinsville, Georgia
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 7, 2026, 4:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

RM1 Project 2 - tAN fMRI

NCT05487664
View directory record Official record
Conditions
Auricular Stimulation
Interventions
Transcutaneous Auricular Neruostimulation (tAN)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 7, 2026, 4:26 PM EDT