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ClinicalTrials.gov public records Last synced Oct 20, 2026, 3:56 PM EDT

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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sham CES Clear all
Active, not recruiting Not applicable Interventional

Novel Mental Health Therapies to Improve Military Readiness

NCT05887713
View directory record Official record
Conditions
Anxiety, Alpha Stim, Cranial Electrotherapy Stimulation, Cognitive Behavioral Therapy, Heart Rate Variability
Interventions
Experimental: Alpha-Stim 100, Sham Comparator
Device
Lead sponsor
David Moss
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Nellis Air Force Base, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional

Cranial Electrotherapy for Military Beneficiaries With Restless Legs Syndrome

NCT02419014
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
Active CES Device Alpha-Stim®, Sham Device
Device
Lead sponsor
Tripler Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 20, 2026, 3:56 PM EDT
Recruiting Not applicable Interventional

Cranial Electrotherapy Stimulation and Brain Imaging for Gulf War Syndrome

NCT07151248
View directory record Official record
Conditions
Gulf War Syndrome
Interventions
Cranial electrical/electrotherapy stimulation (CES), Sham Cranial electrical/electrotherapy stimulation (CES)
Device
Lead sponsor
Emory University
Other
Eligibility
40 Years to 80 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 20, 2026, 3:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Cranial Electric Stimulation to Modify Suicide Risk Factors in Psychiatric Inpatients.

NCT02846740
View directory record Official record
Conditions
Suicide, Depression, Anxiety, Insomnia, Agitation
Interventions
Alpha-Stim®., Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, The Pittsburgh Sleep Quality Index and agitated behavior Scale
Device · Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 26, 2019 · Synced Oct 20, 2026, 3:56 PM EDT
Active, not recruiting Not applicable Interventional

Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders

NCT03540745
View directory record Official record
Conditions
Depression, Anxiety, Insomnia, Substance Abuse
Interventions
TES Treatment, TES-SHAM Treatment
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Belle Mead, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Results available

Cranial Electrical Stimulation Effects on Symptoms in Persons With Fibromyalgia

NCT00928720
View directory record Official record
Conditions
Fibromyalgia
Interventions
CES device, sham device
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 3, 2018 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Cranial Electrotherapy Stimulation (CES) on Brain Function, Brain Chemistry and Mood

NCT01860677
View directory record Official record
Conditions
Mood
Interventions
Fisher Wallace Cranial Stimulator
Device
Lead sponsor
Mclean Hospital
Other
Eligibility
21 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2017 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effectiveness of CES on Emotional and Cellular Wellbeing

NCT03369418
View directory record Official record
Conditions
Anxiety, Depression
Interventions
Alpha-Stim Active, Alpha-Stim Inactive
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2020 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Results available

A Single Blind Study of Cranial Electrical Stimulation in Bipolar II Disorder

NCT01909011
View directory record Official record
Conditions
Bi-polar II Disorder
Interventions
Active CES, Sham CES
Device
Lead sponsor
Beth Israel Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 24, 2015 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of CES on Parasympathetic Tone

NCT02163967
View directory record Official record
Conditions
Autonomic Nervous System Imbalance
Interventions
Cranial Electrical Stimulation Fisher-Wallace Stimulator (Model FW100)
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2019 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cranial Electrotherapy Stimulation and Acute Stress

NCT06034496
View directory record Official record
Conditions
Anxiety State
Interventions
Active CES, Sham CES
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years to 40 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Medford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Phase 4 Interventional

Use of Alpha-Stim Cranial-electrotherapy Stimulation (CES) in the Treatment of Anxiety

NCT01533415
View directory record Official record
Conditions
Anxiety
Interventions
CES treatment using Alpha-Stim technology, Shame CES Treatment
Device
Lead sponsor
Wyndhurst Counseling Center
Other
Eligibility
18 Years to 65 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
2
States / cities
Lynchburg, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 9, 2013 · Synced Oct 20, 2026, 3:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of CES in New Mothers During the Post Partum Period

NCT03210155
View directory record Official record
Conditions
Anxiety, Depression, Insomnia, Sleep Quality
Interventions
Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator)
Device
Lead sponsor
Christina Murphey, RN, PhD
Individual
Eligibility
18 Years to 45 Years · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Austin, Texas • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Efficacy of Cranial Electrotherapy Stimulation in Mitigating Anxiety-induced Cognitive Deficits

NCT04961112
View directory record Official record
Conditions
Anxiety, Cognitive Deficit
Interventions
Cranial Electrotherapy Stimulation, Sham Cranial Electrotherapy Stimulation
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years to 28 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Medford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Oct 20, 2026, 3:56 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Brain Stimulation & Generalized Anxiety Study

NCT04751864
View directory record Official record
Conditions
Anxiety, Generalized Anxiety Disorder, Generalized Anxiety
Interventions
Cranial Electrotherapy Stimulator (CES) Device
Device
Lead sponsor
ProofPilot
Industry
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2021 · Synced Oct 20, 2026, 3:56 PM EDT
Terminated Not applicable Interventional Results available

Cranial Electrical Stimulation (CES) as Treatment for Insomnia in Patients With Subacute Stroke

NCT03344562
View directory record Official record
Conditions
Cerebrovascular Accident, Sleep Disorder
Interventions
CES
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 19, 2020 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Results available

The Efficacy of Cranial Electrostimulating Therapy for Depression and Anxiety Among Homeless Adults

NCT02732561
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Alpha Stim device, Sham device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Oct 20, 2026, 3:56 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Evaluation of a Neurostimulation Device for Insomnia: A Randomized Trial

NCT04627480
View directory record Official record
Conditions
Insomnia, Insomnia Chronic, Sleep
Interventions
Fisher Wallace Neurostimulation Device
Device
Lead sponsor
ProofPilot
Industry
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Results available

Self Cranial Electrical Stimulation (CES) for Pain in Older Adults With Knee Osteoarthritis (Self CES for Knee Pain)

NCT04016259
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cranial Electrical Stimulation (CES), Sham-CES
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
50 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Oct 20, 2026, 3:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Efficacy of Cranial Electrotherapy Stimulation (CES) for the Treatment of Major Depressive Disorder

NCT03222752
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Cranial Electrotherapy Stimulation, Sham Cranial Electrotherapy Stimulation
Device
Lead sponsor
Electromedical Products International, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Forest, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 20, 2026, 3:56 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

New Mothers Alpha-Stim

NCT04770181
View directory record Official record
Conditions
Anxiety, Depression, Insomnia, Sleep Quality
Interventions
Alpha-Stim AID CES (Active Comparator), Alpha-Stim AID CES (Sham Comparator)
Device
Lead sponsor
Christina Murphey, RN, PhD
Individual
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Austin, Texas • Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional

CES for the Treatment of GAD in Young Adults

NCT06124014
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
At-Home Stimulation
Device
Lead sponsor
Electromedical Products International, Inc.
Industry
Eligibility
18 Years to 21 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Results available

Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD)

NCT01325532
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Active CES, Sham CES
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 1, 2016 · Synced Oct 20, 2026, 3:56 PM EDT
Completed Not applicable Interventional Results available

Randomized Controlled Trial of CES for Fibromyalgia

NCT04115033
View directory record Official record
Conditions
Fibromyalgia
Interventions
Alpha-stim
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 20, 2026, 3:56 PM EDT