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These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 19, 2026, 3:37 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 30 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sham LIFU Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

NCT04197921
View directory record Official record
Conditions
Opioid-use Disorder, Substance Use Disorders
Interventions
Exablate Model 4000 Type 2.0/2.1
Device
Lead sponsor
InSightec
Industry
Eligibility
18 Years to 60 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
4
States / cities
Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

OCD LIFU Target Engagement

NCT07558148
View directory record Official record
Conditions
Obsessive Compulsive Disorder (OCD)
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

LIFU for Treatment for Refractory Opioid Use Disorder

NCT06218706
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Low Intensity Focussed Ultrasound
Device
Lead sponsor
Ali Rezai
Other
Eligibility
22 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of Low-intensity Focused Ultrasound for Human Pain Management

NCT05145426
View directory record Official record
Conditions
Chronic Pain
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula

NCT06906211
View directory record Official record
Conditions
Chronic Back Pain, Chronic Pain (Back / Neck)
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
21 Years to 75 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

Low Intensity Focused Ultrasound for Tobacco Use Disorder: High Resolution Targeting of the Human Insula

NCT06405074
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Oct 19, 2026, 3:37 PM EDT
Enrolling by invitation Not applicable Interventional

Mild Cognitive Impairment and Neuromodulation

NCT07691918
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
Low intensity focused ultrasound, Sham (No Treatment)
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
55 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Enrolling by invitation Not applicable Interventional

Low-Intensity Focused Ultrasound Neuromodulation for Epilepsy

NCT07353918
View directory record Official record
Conditions
Epilepsy (Treatment Refractory), Epilepsy Comorbidities
Interventions
Low-intensity Focused Ultrasound, Sham
Device
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Not yet recruiting Not applicable Interventional

LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI)

NCT07710989
View directory record Official record
Conditions
Schizophrenia, Auditory Hallucinations
Interventions
LIFU
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression

NCT07166289
View directory record Official record
Conditions
Treatment-Resistant Depression
Interventions
Low-intensity focused ultrasound
Other
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Low-intensity Focused Ultrasound and Autonomic Response

NCT05834829
View directory record Official record
Conditions
Autonomic Dysfunction
Interventions
Low-intensity focused ultrasound neuromodulation, Sham Low-intensity focused ultrasound
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

NCT05303415
View directory record Official record
Conditions
Pain
Interventions
Neuromodulation with low-intensity focused ultrasound
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low-Intensity Focused Ultrasound for Cocaine Use Disorder

NCT05857852
View directory record Official record
Conditions
Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
Interventions
Low-Intensity Focused Ultrasound, Sham LIFU device
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering

NCT07668882
View directory record Official record
Conditions
Stuttering, Developmental Stuttering
Interventions
High DC LIFU, Sham
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

Ultrasound Neuromodulation in Essential Tremor

NCT06610877
View directory record Official record
Conditions
Essential Tremor, Neuromodulation
Interventions
Focused Ultrasound Neuromodulation - Sham Control, Focused ultrasound neuromodulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

Low-Intensity Focused Ultrasound and the Complex Patient

NCT06297200
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain, Anxiety Disorder
Interventions
Low-Intensity Focused Ultrasound, Low-Intensity Focused Ultrasound - sham
Device
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 3, 2025 · Synced Oct 19, 2026, 3:37 PM EDT
Not yet recruiting Not applicable Interventional

Development of Low-Intensity Focused Ultrasound for Post Traumatic Brain Injury Depression

NCT07828483
View directory record Official record
Conditions
Post-traumatic Brain Injury Depression, Veteran Health
Interventions
Active Low-Intensity Focused Ultrasound (LIFU), Sham Low-Intensity Focused Ultrasound (LIFU)
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
22 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Completed Not applicable Interventional

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD)

NCT06612788
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Exablate Model 4000 Type 2.0/2.1
Device
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 19, 2026, 3:37 PM EDT
Terminated Not applicable Interventional

Decision Making in Chronic Pain and Alcohol Use Disorder

NCT05901610
View directory record Official record
Conditions
Alcohol Use Disorder, Chronic Pain
Interventions
Episodic Future Thinking, Control Episodic Thinking, Low-intensity Focused Ultrasound, Sham Low-intensity Focused Ultrasound
Behavioral · Device
Lead sponsor
Kirstin M Gatchalian
Other
Eligibility
21 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

LIFU Mechanisms for PTSD in Healthcare Workers

NCT07164105
View directory record Official record
Conditions
PTSD and Trauma-related Symptoms
Interventions
Low intensity focused ultrasound, Sham modulation
Device
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Focused Ultrasound for the Complex Patient

NCT06453109
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Back Pain, Anxiety
Interventions
low intensity focused ultrasound (LIFU)
Device
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Oct 19, 2026, 3:37 PM EDT
Not listed Not applicable Interventional

Low-Intensity Focused Ultrasound For Insular Neuromodulation in Chronic Pain

NCT05751096
View directory record Official record
Conditions
Fibromyalgia, Complex Regional Pain Syndromes, Chronic Pain
Interventions
Low-intensity Focused Ultrasound (LIFU), Sham Low-intensity focused ultrasound (LIFU)
Device
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 16, 2023 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional

Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

NCT07680842
View directory record Official record
Conditions
Drug-Resistant Epilepsy, Epilepsy, Epilepsy (Treatment Refractory), Epilepsy Comorbidities, Epilepsy, Drug Resistant, Epilepsy, Generalized, Epilepsy, Focal
Interventions
Target optimization using LIFU, Serial LIFU stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 19, 2026, 3:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-Invasive Deep Brain Neuromodulation for Smoking Cessation

NCT07298902
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Low intensity focused ultrasound with active stimulations, low intensity focused ultrasound with sham stimulations
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
20 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 19, 2026, 3:37 PM EDT