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ClinicalTrials.gov public records Last synced Oct 30, 2026, 5:56 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 119 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Sham Light Device Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Noise Exposure and Near-Infrared Light

NCT03834714
View directory record Official record
Conditions
Hearing Loss, Noise-Induced
Interventions
Near Infrared Light, Noise Stimulus, Sham Near Infrared Light
Device · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 45 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
3
States / cities
Fort Rucker, Alabama • Miami, Florida • Wright-Patterson Air Force Base, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 19, 2022 · Synced Oct 30, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional

ENhancing Exercise With LIGHT to Improve Functioning in PAD

NCT06399900
View directory record Official record
Conditions
Peripheral Artery Disease, Peripheral Vascular Disease, Aging, Walking, Difficulty
Interventions
Far red light therapy, Sham light therapy, Home-based walking exercise
Device · Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
50 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 30, 2026, 5:56 PM EDT
Suspended Not applicable Interventional

Neuro RX Gamma - Pivotal Phase

NCT03484143
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Active Neuro RX Gamma device, Sham Neuro RX Gamma device
Device
Lead sponsor
Vielight Inc.
Industry
Eligibility
50 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 30, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

NCT07095556
View directory record Official record
Conditions
Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management, Tooth Extraction Site Healing
Interventions
Low-level laser therapy
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus

NCT03442751
View directory record Official record
Conditions
Progressive Keratoconus
Interventions
Test Article A, Test Article B, Placebo, KXL medical device system
Drug · Device
Lead sponsor
Glaukos Corporation
Industry
Eligibility
12 Years to 55 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 30, 2024 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Phase 1 Interventional

A Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment

NCT05857124
View directory record Official record
Conditions
Post COVID-19 Cognitive Impairment
Interventions
Vielight Neuro RX Gamma active device, Vielight Neuro RX Gamma sham device
Device
Lead sponsor
Vielight Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2025 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Meibomian Gland Dysfunction Treatment

NCT04229888
View directory record Official record
Conditions
Meibomian Gland Dysfunction, Dry Eye
Interventions
LipiFlow, Light Based (Sham) Treatment
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 29, 2022 · Synced Oct 30, 2026, 5:56 PM EDT
Active, not recruiting Not applicable Interventional

Assessing Feasibility of Prolonged Repetitive Near Infrared Light Stimulation in Early to Mid-Stage Dementia

NCT03750409
View directory record Official record
Conditions
Mild to Moderate Dementia
Interventions
Helmet
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
50 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
2
States / cities
Elkins Park, Pennsylvania • Temple, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Oct 30, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional

Effects of Transcranial Photobiomodulation in ADHD

NCT07203092
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder
Interventions
Active transcranial photobiomodulation, Sham transcranial photobiomodulation
Device
Lead sponsor
Francisco Gonzalez-Lima, PhD
Other
Eligibility
18 Years to 44 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional

Photobiomodulation Therapy in Persons With Multiple Sclerosis

NCT03691766
View directory record Official record
Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
Photobiomodulation Therapy, Placebo
Other
Lead sponsor
Marquette University
Other
Eligibility
20 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 26, 2021 · Synced Oct 30, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional

Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients

NCT06708754
View directory record Official record
Conditions
Radiation Lymphedema, Radiation Fibrosis, Head and Neck Cancer
Interventions
Photobiomodulation (PBM) Therapy, Sham PBM
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Treating Cancer-Related Fatigue Through Systematic Light Exposure (Light for Fatigue Study)

NCT03119363
View directory record Official record
Conditions
Multiple Myeloma, Fatigue
Interventions
AYO light glasses (Experimental), AYO light glasses (Comparator)
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
3
States / cities
Hackensack, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2022 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cranial Laser Reflex Technique for Hamstring Function

NCT03044106
View directory record Official record
Conditions
Hamstring Injury, Muscle Tone Increased, Muscle Pain, Muscle Weakness
Interventions
CLRT
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 12, 2019 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional

Photobiomodulation to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Head & Neck Cancer Patients

NCT03972527
View directory record Official record
Conditions
Oral Mucositis (Ulcerative), Oral Mucositis (Ulcerative) Due to Radiation, Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy, Head and Neck Cancer
Interventions
Photobiomodulation, Routine Oral Care and Analgesia
Device · Other
Lead sponsor
MuReva Phototherapy Inc.
Industry
Eligibility
22 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
12
States / cities
Birmingham, Alabama • Long Beach, California • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Oct 30, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional

Integrated Platform for Measuring and Reducing Symptoms of Autism Spectrum Disorder

NCT06006637
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Cognilum TM: Light Treatment Condition
Device
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
2 Years to 8 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
New York, New York • Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 30, 2026, 5:56 PM EDT
Not yet recruiting Not applicable Interventional

LET for Fibromyalgia

NCT07201818
View directory record Official record
Conditions
Fibromyalgia
Interventions
Lymphatic Enhancement Technology (LET), Sham Lymphatic Enhancement Technology (LET)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Low-Level Laser Therapy for Plantar Fasciitis

NCT05763381
View directory record Official record
Conditions
Plantar Fascitis
Interventions
Photobiomodulation Therapy (PBMT), Sham-Photobiomodualtion Therapy (Sham-PBMT)
Device
Lead sponsor
The Geneva Foundation
Other
Eligibility
18 Years to 64 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional

Noxipoint Therapy Versus Standard Physical Therapy Using Electrical Stimulation for Chronic Pain

NCT01578148
View directory record Official record
Conditions
Shoulder Pain, Neck Pain
Interventions
Noxipoint Therapy, Physical Therapy
Procedure
Lead sponsor
Pain Cure Center, California
Industry
Eligibility
18 Years to 64 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2013 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Effects of Reducing Indoor Air Pollution on the Adult Asthmatic Response

NCT02153359
View directory record Official record
Conditions
Asthma
Interventions
High Efficiency Particulate Air Cleaner, Sham air cleaner
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 12, 2019 · Synced Oct 30, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional

Photobiomodulation for Management of Temporomandibular Disorder Pain

NCT05916235
View directory record Official record
Conditions
Pain Related to TMD
Interventions
THOR® laser system
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 30, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease

NCT05776641
View directory record Official record
Conditions
Alzheimer Disease, Family Members
Interventions
GENUS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
55 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Intense Pulsed Light for Improving Dry Eye Syndrome

NCT03396913
View directory record Official record
Conditions
Dry Eye Syndrome
Interventions
IPL, Sham IPL, MGX
Device · Procedure
Lead sponsor
Lumenis Be Ltd.
Industry
Eligibility
22 Years to 85 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Nashville, Tennessee • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Oct 30, 2026, 5:56 PM EDT
Terminated Phase 3 Interventional Results available

Safety Study of the VEGA UV-A System to Treat Keratoconus

NCT01190306
View directory record Official record
Conditions
Keratoconus
Interventions
The VEGA UV-A Illumination System, Riboflavin
Device · Drug
Lead sponsor
Topcon Medical Systems, Inc.
Industry
Eligibility
12 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
9
States / cities
Phoenix, Arizona • Atlanta, Georgia • Bloomington, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2022 · Synced Oct 30, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Revitalize Cognition: Near Infrared Stimulation in Parkinson Patients

NCT06688357
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active NIR-PBM (MedX 1116, MCT502), Sham NIR-PBM (MedX 1116, MCT502)
Device
Lead sponsor
University of Florida
Other
Eligibility
62 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2025 · Synced Oct 30, 2026, 5:56 PM EDT