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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Sham Smoking Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Approach Bias Retraining to Augment Smoking Cessation

NCT03325777
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Approach Bias Retraining, SHAM Training
Behavioral
Lead sponsor
Jasper A. Smits
Other
Eligibility
18 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 21, 2026, 3:31 AM EDT
Terminated Not applicable Interventional Results available

QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt

NCT03576768
View directory record Official record
Conditions
Smoking, Cigarette, Craving, Addiction, Nicotine
Interventions
Real cTBS, Sham cTBS, Real iTBS, Sham iTBS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Changing Thought and Action in Tobacco Dependence With Transcranial Magnetic Stimulation

NCT00973622
View directory record Official record
Conditions
Tobacco Dependence
Interventions
repetitive transcranial magnetic stimulation (rTMS) 10 Hertz (Hz), repetitive transcranial magnetic stimulation (rTMS) 20Hz, SHAM repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
University of Arkansas
Other
Eligibility
19 Years to 55 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2013 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Results available

QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt

NCT04159571
View directory record Official record
Conditions
Smoking, Smoking Cessation, Craving, Addiction, Addiction Nicotine, Nicotine Dependence, Cigarette Smoking
Interventions
Real TBS to the vmPFC, Sham cTBS to the vmPFC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Results available

Motivational Interviewing and Air Cleaners for Smokers With COPD (MOVE COPD)

NCT03658538
View directory record Official record
Conditions
COPD, Chronic Obstructive Pulmonary Disease
Interventions
Active HEPA Air Cleaner, Motivational interviewing, Sham Air Cleaner
Device · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
40 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of LLLT/Music for Smoking Cessation

NCT04830384
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
Fully Active, LLLT Only, Music Only, Placebo
Device
Lead sponsor
Freedom Laser, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Mendham, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 4, 2021 · Synced Sep 21, 2026, 3:31 AM EDT
Recruiting Phase 2 Interventional

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

NCT05723588
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation, nicotine replacement therapy
Device · Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Early Phase 1 Interventional

Theta Burst TMS as a Tool to Change Smoking Behavior

NCT02939339
View directory record Official record
Conditions
Smoking, Addiction
Interventions
continuous theta burst stimulation (real), continuous theta burst stimulation (sham)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2018 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors

NCT03386253
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
active tDCS, sham tDCS
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Sep 21, 2026, 3:31 AM EDT
Enrolling by invitation Not applicable Interventional

Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of Gastroesophageal Reflux Disease (GERD)

NCT04960566
View directory record Official record
Conditions
Gastroesophageal Reflux
Interventions
Cognitive Behavioral Therapy, Sham-SOC Lifestyle Coaching
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Sep 21, 2026, 3:31 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Investigation of the Effects of Electronic Cigarettes on Vascular Health

NCT03041493
View directory record Official record
Conditions
Vascular Health
Interventions
Electronic cigarette, traditional cigarette, (sham cigarette) - no actual exposure to cigarettes
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2021 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Results available

Nicotine Withdrawal Symptoms and Smoking Relapse

NCT01511614
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Transcranial Direct Current Stimulation, sham, Nicotine patch, Placebo patch, Varenicline Pill, Placebo pill, Motivational Interviewing
Device · Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Results available

Effect of Smoking Exposure on Smoking Relapse Following Brief Abstinence - 2

NCT00136838
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Neutral or active cigarette cues
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2018 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of AAT Training in Smokers

NCT02481752
View directory record Official record
Conditions
Tobacco Use
Interventions
Approach Avoidance Training, SHAM Training
Other
Lead sponsor
Jasper A. Smits
Other
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 21, 2026, 3:31 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-Invasive Deep Brain Neuromodulation for Smoking Cessation

NCT07298902
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Low intensity focused ultrasound with active stimulations, low intensity focused ultrasound with sham stimulations
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
20 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Results available

Smartphone-Delivered Attentional Bias Modification Training in Helping Patients Quit Smoking

NCT02224391
View directory record Official record
Conditions
Current Every Day Smoker
Interventions
Computer-Assisted Smoking Cessation Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Sham Intervention
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
311 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation.

NCT02126124
View directory record Official record
Conditions
Smoking Cessation
Interventions
Sham Treatment, Active dTMS Treatment
Device
Lead sponsor
Brainsway
Industry
Eligibility
22 Years to 70 Years
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
14
States / cities
Los Angeles, California • San Diego, California • Denver, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Sep 21, 2026, 3:31 AM EDT
Recruiting Phase 4 Interventional

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

NCT07145866
View directory record Official record
Conditions
Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation, Smoking (Tobacco) Addiction
Interventions
Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham, Nicotine Cessation Counseling, D-cycloserine
Drug · Device · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Results available

Accelerated Transcranial Magnetic Stimulation (TMS) for Smoking Cessation in People Living With HIV/AIDS (PLWHA)

NCT05295953
View directory record Official record
Conditions
Hiv, Tobacco Smoking
Interventions
TBS, Sham TMS
Device
Lead sponsor
Gopalkumar Rakesh
Other
Eligibility
18 Years to 60 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Sep 21, 2026, 3:31 AM EDT
Terminated Phase 2 Interventional

Helping Veterans Quit Smoking by Improving Their Sleep

NCT01267032
View directory record Official record
Conditions
Smoking
Interventions
Integrated Care, Cognitive-Behavioral Treatment for Insomnia, Desensitization Treatment for Insomnia
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Results available

AAT + tDCS to Reduce Cue-induced Craving and Smoking Behavior

NCT05426460
View directory record Official record
Conditions
Smoking Behaviors, Smoking, Cigarette
Interventions
Approach/Avoidance Task, Transcranial Direct Current Stimulation, AC, Sham tDCS
Behavioral · Device
Lead sponsor
Cynthia Conklin
Other
Eligibility
26 Years to 55 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 21, 2026, 3:31 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users

NCT05401929
View directory record Official record
Conditions
Cannabis
Interventions
iTBS
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 21, 2026, 3:31 AM EDT
Recruiting Not applicable Interventional

Shaping Habitual Impulses For a Tobacco-free Style

NCT07025772
View directory record Official record
Conditions
ST+ABR, ST+SHAM, ST-only
Interventions
ST+ABR, ST+Sham, ST Only
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 21, 2026, 3:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction

NCT02401672
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Transcranial magnetic stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 20, 2020 · Synced Sep 21, 2026, 3:31 AM EDT